Ptpn23 protein tyrosine phosphatase, non-receptor type 23 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptpn23provided by MGI
Official Full Name: protein tyrosine phosphatase, non-receptor type 23provided by MGI
Primary source: MGI:MGI:2144837
See related: Ensembl:ENSMUSG00000036057 AllianceGenome:MGI:2144837
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PTP-TD14
Summary: Predicted to enable protein kinase binding activity and protein tyrosine phosphatase activity. Predicted to be involved in several processes, including early endosome to late endosome transport; positive regulation of adherens junction organization; and positive regulation of transport. Predicted to act upstream of or within cell projection organization and protein transport. Predicted to be located in ciliary basal body; early endosome; and nuclear body. Is expressed in several structures, including alimentary system; central nervous system; gonad; respiratory system epithelium; and skin. Orthologous to human PTPN23 (protein tyrosine phosphatase non-receptor type 23). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 17.6), limb E14.5 (RPKM 12.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F2; 9 59.92 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (110214152..110237278, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (110385084..110408210, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PTPN23 binds the dynein adaptor BICD1 and is required for endocytic sorting of neurotrophin receptors.
Title: PTPN23 binds the dynein adaptor BICD1 and is required for endocytic sorting of neurotrophin receptors.
HD-PTP/PTPN23 as a prominent haploinsufficient tumor suppressor gene preventing tumor progression through control of integrin trafficking.
Title: Haploinsufficiency of the ESCRT Component HD-PTP Predisposes to Cancer.
The role of HD-PTP/PTPN23 in cancer and tumorigenesis is reviewed.
Title: Role of ESCRT component HD-PTP/PTPN23 in cancer.
HD-PTP affects the intracellular sorting of activated PDGFRbeta and the migration, proliferation and tumorigenicity of cells stimulated by PDGF.
Title: Histidine-domain-containing protein tyrosine phosphatase regulates platelet-derived growth factor receptor intracellular sorting and degradation.
PTPN23 is a tumor suppressor and that repression of PTPN23 expression by miR-142-3p plays an important role in the pathogenesis of testicular germ cell tumors.
Title: Tumor-suppressive function of protein-tyrosine phosphatase non-receptor type 23 in testicular germ cell tumors is lost upon overexpression of miR142-3p microRNA.
homozygous gene deletion is lethal around embryonic day 9.5, suggesting that Ptpn23 is an essential requirement for early stages of embryonic development
Title: Expression analysis and essential role of the putative tyrosine phosphatase His-domain-containing protein tyrosine phosphatase (HD-PTP).

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2)
Targeted (2)
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D9Mit292 (e-PCR), detects polymorphism
- UniSTS:131860

Ptpn23 (e-PCR), detects polymorphism
- UniSTS:527196

AI462446 (e-PCR)
- UniSTS:165816

UniSTS:236259 (e-PCR)
- UniSTS:236259

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in early endosome to late endosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in early endosome to late endosome transport	ISO Inferred from Sequence Orthology more info
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytic recycling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Wnt protein secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of adherens junction organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of early endosome to late endosome transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of homophilic cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tyrosine-protein phosphatase non-receptor type 23

NP_001074512.1

EC 3.1.3.48

XP_011241233.1

EC 3.1.3.48

XP_030099856.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081043.1 → NP_001074512.1 tyrosine-protein phosphatase non-receptor type 23

See identical proteins and their annotated locations for NP_001074512.1

Status: VALIDATED

Source sequence(s)

BC059902, BY008138, CA325506, CF538443, CF734421

Consensus CDS

CCDS40780.1

UniProtKB/Swiss-Prot

Q69ZJ0, Q6PB44, Q8R1Z5, Q923E6

Related

ENSMUSP00000039580.8, ENSMUST00000040021.12

Conserved Domains (5) summary

cd09234
Location:362 → 702

V_HD-PTP_like; Protein-interacting V-domain of mammalian His-Domain type N23 protein tyrosine phosphatase and related domains

cd09239
Location:2 → 357

BRO1_HD-PTP_like; Protein-interacting, N-terminal, Bro1-like domain of mammalian His-Domain type N23 protein tyrosine phosphatase and related domains

cd00047
Location:1276 → 1505

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

pfam00102
Location:1276 → 1506

Y_phosphatase; Protein-tyrosine phosphatase

pfam13949
Location:417 → 703

ALIX_LYPXL_bnd; ALIX V-shaped domain binding to HIV

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

110214152..110237278 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011242931.3 → XP_011241233.1 tyrosine-protein phosphatase non-receptor type 23 isoform X2

Conserved Domains (4) summary

cd09234
Location:169 → 509

V_HD-PTP_like; Protein-interacting V-domain of mammalian His-Domain type N23 protein tyrosine phosphatase and related domains

PHA03247
Location:540 → 946

PHA03247; large tegument protein UL36; Provisional

cd14539
Location:1106 → 1310

PTP-N23; PTP-like domain of tyrosine-protein phosphatase non-receptor type 23

cl14649
Location:1 → 164

BRO1_Alix_like; Protein-interacting Bro1-like domain of mammalian Alix and related domains
XM_030243996.2 → XP_030099856.1 tyrosine-protein phosphatase non-receptor type 23 isoform X1

Conserved Domains (4) summary

cd09234
Location:279 → 619

V_HD-PTP_like; Protein-interacting V-domain of mammalian His-Domain type N23 protein tyrosine phosphatase and related domains

PHA03247
Location:650 → 1056

PHA03247; large tegument protein UL36; Provisional

cd14539
Location:1216 → 1420

PTP-N23; PTP-like domain of tyrosine-protein phosphatase non-receptor type 23

cl14649
Location:1 → 274

BRO1_Alix_like; Protein-interacting Bro1-like domain of mammalian Alix and related domains