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    Aspg asparaginase [ Mus musculus (house mouse) ]

    Gene ID: 104816, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Aspgprovided by MGI
    Official Full Name
    asparaginaseprovided by MGI
    Primary source
    MGI:MGI:2144822
    See related
    Ensembl:ENSMUSG00000037686 AllianceGenome:MGI:2144822
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm690; A530050D06Rik
    Summary
    Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups; asparaginase activity; and carboxylic ester hydrolase activity. Predicted to be involved in asparagine metabolic process and phospholipid metabolic process. Predicted to act upstream of or within lipid catabolic process. Orthologous to human ASPG (asparaginase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 84.5), colon adult (RPKM 14.5) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 F1; 12 61.14 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (112073117..112094007)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (112106683..112127573)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene tudor domain containing 9 Neighboring gene retinal degeneration 3-like Neighboring gene predicted gene, 46381 Neighboring gene microRNA 3073a Neighboring gene microRNA 3073b Neighboring gene microRNA 203b Neighboring gene microRNA 203 Neighboring gene kinesin family member 26A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways. Narayan SB, et al. PLoS One, 2012. PMID 22496890, Free PMC Article
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-alkyl-2-acetylglycerophosphocholine esterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity, transferring groups other than amino-acyl groups ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables asparaginase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables asparaginase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysophospholipase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidyl phospholipase B activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in asparagine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    60 kDa lysophospholipase
    Names
    60 kDa lysophospholipase [Includes: L-asparaginase
    asparaginase homolog
    lysophospholipase-transacylase
    NP_001074638.1
    XP_006515408.1
    XP_006515409.1
    XP_006515410.1
    XP_006515411.1
    XP_006515412.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081169.1 → NP_001074638.1  60 kDa lysophospholipase

      See identical proteins and their annotated locations for NP_001074638.1

      Status: PROVISIONAL

      Source sequence(s)
      AC112520
      Consensus CDS
      CCDS36567.1
      UniProtKB/Swiss-Prot
      A0JNU3
      Related
      ENSMUSP00000078369.5, ENSMUST00000079400.6
      Conserved Domains (3) summary
      PLN03192
      Location:373 → 550
      PLN03192; Voltage-dependent potassium channel; Provisional
      sd00045
      Location:430 → 461
      ANK; ANK repeat [structural motif]
      cl00216
      Location:9 → 361
      L-asparaginase_like; Bacterial L-asparaginases and related enzymes

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      112073117..112094007
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515345.5 → XP_006515408.1  60 kDa lysophospholipase isoform X1

      Conserved Domains (3) summary
      PLN03192
      Location:330 → 507
      PLN03192; Voltage-dependent potassium channel; Provisional
      sd00045
      Location:387 → 418
      ANK; ANK repeat [structural motif]
      cl00216
      Location:31 → 318
      L-asparaginase_like; Bacterial L-asparaginases and related enzymes

    2. XM_006515346.1 → XP_006515409.1  60 kDa lysophospholipase isoform X2

      See identical proteins and their annotated locations for XP_006515409.1

      Conserved Domains (3) summary
      PLN03192
      Location:255 → 432
      PLN03192; Voltage-dependent potassium channel; Provisional
      sd00045
      Location:312 → 343
      ANK; ANK repeat [structural motif]
      cl00216
      Location:1 → 243
      L-asparaginase_like; Bacterial L-asparaginases and related enzymes

    3. XM_006515349.1 → XP_006515412.1  60 kDa lysophospholipase isoform X3

      Conserved Domains (3) summary
      PLN03192
      Location:211 → 388
      PLN03192; Voltage-dependent potassium channel; Provisional
      sd00045
      Location:268 → 299
      ANK; ANK repeat [structural motif]
      cl00216
      Location:2 → 199
      L-asparaginase_like; Bacterial L-asparaginases and related enzymes

    4. XM_006515348.1 → XP_006515411.1  60 kDa lysophospholipase isoform X2

      See identical proteins and their annotated locations for XP_006515411.1

      Conserved Domains (3) summary
      PLN03192
      Location:255 → 432
      PLN03192; Voltage-dependent potassium channel; Provisional
      sd00045
      Location:312 → 343
      ANK; ANK repeat [structural motif]
      cl00216
      Location:1 → 243
      L-asparaginase_like; Bacterial L-asparaginases and related enzymes

    5. XM_006515347.5 → XP_006515410.1  60 kDa lysophospholipase isoform X2

      See identical proteins and their annotated locations for XP_006515410.1

      Conserved Domains (3) summary
      PLN03192
      Location:255 → 432
      PLN03192; Voltage-dependent potassium channel; Provisional
      sd00045
      Location:312 → 343
      ANK; ANK repeat [structural motif]
      cl00216
      Location:1 → 243
      L-asparaginase_like; Bacterial L-asparaginases and related enzymes
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0JNU3.1 GenPept UniProtKB/Swiss-Prot:A0JNU3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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