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    Zfp120 zinc finger protein 120 [ Mus musculus (house mouse) ]

    Gene ID: 104348, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Zfp120provided by MGI
    Official Full Name
    zinc finger protein 120provided by MGI
    Primary source
    MGI:MGI:1345179
    See related
    Ensembl:ENSMUSG00000068134 AllianceGenome:MGI:1345179
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    F80; MZF31; Zfp844; E030042N05Rik
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in eye and genitourinary system. Orthologous to human ZNF101 (zinc finger protein 101) and ZNF699 (zinc finger protein 699). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 1.4), CNS E18 (RPKM 1.2) and 24 other tissues See more
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    Genomic context

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    Location:
    2 G3; 2 74.0 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (149956327..149978598, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (150114407..150136678, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene synapse differentiation inducing 1 Neighboring gene sal-like 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_05993 Neighboring gene STARR-seq mESC enhancer starr_05996 Neighboring gene STARR-seq mESC enhancer starr_05997 Neighboring gene REX4, RNA exonuclease 4 homolog pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1011 Neighboring gene predicted gene 10770 Neighboring gene predicted gene, 52531 Neighboring gene zinc finger protein 1004

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Comparative analysis of KRAB zinc finger proteins in rodents and man: evidence for several evolutionarily distinct subfamilies of KRAB zinc finger genes. Mark C, et al. DNA Cell Biol, 1999 May. PMID 10360839
    2. Strain survey and genetic analysis of vasoreactivity in mouse aorta. Kim SK, et al. Physiol Genomics, 2016 Nov 1. PMID 27764765, Free PMC Article
    3. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
    4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 120
    Names
    zinc finger protein 31
    zinc finger protein 844

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023266.4 → NP_075755.4  zinc finger protein 120 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AF211869, AK033399, AK132318
      Consensus CDS
      CCDS38264.1
      UniProtKB/TrEMBL
      A2ANU5, Q9EQK2
      Related
      ENSMUSP00000105557.2, ENSMUST00000109931.8
      Conserved Domains (2) summary
      smart00349
      Location:28 → 68
      KRAB; krueppel associated box
      pfam01352
      Location:28 → 67
      KRAB; KRAB box

    2. NM_181266.2 → NP_851783.2  zinc finger protein 120 isoform 1 precursor

      See identical proteins and their annotated locations for NP_851783.2

      Status: VALIDATED

      Source sequence(s)
      AK033399, AK132318
      Consensus CDS
      CCDS38263.1
      UniProtKB/Swiss-Prot
      Q78JR8, Q8BZW4, Q9EQK4, Q9JIB8
      Related
      ENSMUSP00000086615.7, ENSMUST00000089207.13
      Conserved Domains (5) summary
      smart00349
      Location:28 → 69
      KRAB; krueppel associated box
      COG5048
      Location:140 → 387
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:298 → 318
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:28 → 67
      KRAB; KRAB box
      pfam13465
      Location:338 → 363
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      149956327..149978598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_181267.2: Suppressed sequence

      Description
      NM_181267.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BZW4.1 GenPept UniProtKB/Swiss-Prot:Q8BZW4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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