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    Arl1 ADP-ribosylation factor-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 104303, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Arl1provided by MGI
    Official Full Name
    ADP-ribosylation factor-like 1provided by MGI
    Primary source
    MGI:MGI:99436
    See related
    Ensembl:ENSMUSG00000060904 AllianceGenome:MGI:99436
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310008D22Rik
    Summary
    Predicted to enable several functions, including GTP binding activity; GTPase activity; and enzyme activator activity. Predicted to be involved in several processes, including activation of phospholipase D activity; protein localization to Golgi apparatus; and retrograde transport, endosome to Golgi. Located in cytoplasm. Is expressed in genitourinary system and inner ear. Orthologous to human ARL1 (ADP ribosylation factor like GTPase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 60.6), placenta adult (RPKM 54.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 C1; 10 44.19 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (88566720..88579956)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (88730920..88744094)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene Spi-C transcription factor (Spi-1/PU.1 related) Neighboring gene STARR-seq mESC enhancer starr_27509 Neighboring gene predicted gene, 46192 Neighboring gene STARR-positive B cell enhancer ABC_E11454 Neighboring gene predicted gene 4925 Neighboring gene UTP20 small subunit processome component Neighboring gene STARR-seq mESC enhancer starr_27512 Neighboring gene STARR-seq mESC enhancer starr_27513 Neighboring gene solute carrier family 5 (iodide transporter), member 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Knockout of Arfrp1 leads to disruption of ARF-like1 (ARL1) targeting to the trans-Golgi in mouse embryos and HeLa cells. Zahn C, et al. Mol Membr Biol, 2006 Nov-Dec. PMID 17127620
    2. ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli. Lin CY, et al. J Biol Chem, 2000 Dec 1. PMID 10980193
    3. Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells. Schürmann A, et al. J Biol Chem, 1994 Jun 3. PMID 8195219
    4. ADP-ribosylation factor-like GTPase ARFRP1 is required for trans-Golgi to plasma membrane trafficking of E-cadherin. Zahn C, et al. J Biol Chem, 2008 Oct 3. PMID 18662990
    5. In vivo dual-tagging proteomic approach in studying signaling pathways in immune response. Wang T, et al. J Proteome Res, 2005 May-Jun. PMID 15952741

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data suggest that lethality of Arfrp1 knockout embryos is due to a specific disruption of protein targeting, e.g., of ARL1 and Golgin-245, to the Golgi.
      Title: Knockout of Arfrp1 leads to disruption of ARF-like1 (ARL1) targeting to the trans-Golgi in mouse embryos and HeLa cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase D activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi vesicle transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in toxin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosylation factor-like protein 1
    Names
    ADP-ribosylation-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025859.3 → NP_080135.2  ADP-ribosylation factor-like protein 1

      See identical proteins and their annotated locations for NP_080135.2

      Status: PROVISIONAL

      Source sequence(s)
      AK010732
      Consensus CDS
      CCDS36025.1
      UniProtKB/Swiss-Prot
      P41276, P61211
      UniProtKB/TrEMBL
      Q14AC7, Q3TIR2, Q9D7H9
      Related
      ENSMUSP00000111942.3, ENSMUST00000116234.9
      Conserved Domains (1) summary
      cd04151
      Location:19 → 176
      Arl1; ADP ribosylation factor 1 (Arf1)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      88566720..88579956
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244800.2 → XP_030100660.1  ADP-ribosylation factor-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      P41276, P61211
      UniProtKB/TrEMBL
      Q14AC7, Q3TIR2, Q9D7H9
      Conserved Domains (1) summary
      cd04151
      Location:19 → 176
      Arl1; ADP ribosylation factor 1 (Arf1)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61211.1 GenPept UniProtKB/Swiss-Prot:P61211

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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