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    Wdr7 WD repeat domain 7 [ Mus musculus (house mouse) ]

    Gene ID: 104082, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Wdr7provided by MGI
    Official Full Name
    WD repeat domain 7provided by MGI
    Primary source
    MGI:MGI:1860197
    See related
    Ensembl:ENSMUSG00000040560 AllianceGenome:MGI:1860197
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TRAG; mKIAA0541
    Summary
    Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in synaptic vesicle. Predicted to be active in cytoplasm. Is expressed in nervous system; sensory organ; and testis. Orthologous to human WDR7 (WD repeat domain 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 10.9), cortex adult (RPKM 9.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    18 E1; 18 37.09 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (63841731..64122831)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (63708498..63989760)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8721 Neighboring gene STARR-positive B cell enhancer ABC_E9981 Neighboring gene STARR-positive B cell enhancer ABC_E4251 Neighboring gene thioredoxin-like 1 Neighboring gene predicted gene, 41754 Neighboring gene predicted gene, 41753 Neighboring gene STARR-positive B cell enhancer mm9_chr18:63930880-63931180 Neighboring gene STARR-seq mESC enhancer starr_44794 Neighboring gene STARR-seq mESC enhancer starr_44796 Neighboring gene STARR-seq mESC enhancer starr_44797 Neighboring gene proteasome (prosome, macropain) subunit, beta type 1 pseudogene Neighboring gene predicted gene, 24384 Neighboring gene STARR-seq mESC enhancer starr_44798 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_44800 Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3, opposite strand Neighboring gene STARR-seq mESC enhancer starr_44802 Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Assignment of WDR7 (alias TRAG, TGF-beta resistance associated gene) to orthologous regions of human chromosome 18q21.1-->q22 and mouse chromosome 18D.1-E.3 by fluorescence in situ hybridization. Sanders S, et al. Cytogenet Cell Genet, 2000. PMID 10828621
    2. Interactions of Rabconnectin-3 with Cav2 calcium channels. Gandini MA, et al. Mol Brain, 2019 Jun 28. PMID 31253182, Free PMC Article
    3. RNA Binding Protein Ptbp2 Is Essential for Male Germ Cell Development. Zagore LL, et al. Mol Cell Biol, 2015 Dec. PMID 26391954, Free PMC Article
    4. Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice. Ding S, et al. Cell, 2005 Aug 12. PMID 16096065
    5. Mapping the H(+) (V)-ATPase interactome: identification of proteins involved in trafficking, folding, assembly and phosphorylation. Merkulova M, et al. Sci Rep, 2015 Oct 7. PMID 26442671, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 7
    Names
    TGF-beta resistance associated
    TGF-beta resistance-associated protein TRAG

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014981.1 → NP_001014981.1  WD repeat-containing protein 7 isoform 1

      See identical proteins and their annotated locations for NP_001014981.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC102040, AC102132, AC157903
      Consensus CDS
      CCDS50307.1
      UniProtKB/Swiss-Prot
      Q059Q1, Q3U440, Q80TY3, Q920I9, Q920J0
      Related
      ENSMUSP00000072509.6, ENSMUST00000072726.7
      Conserved Domains (3) summary
      COG2319
      Location:341 → 592
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:22 → 62
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:408 → 592
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001360837.1 → NP_001347766.1  WD repeat-containing protein 7 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2 which is shorter, compared to isoform 1.
      Source sequence(s)
      AC102040, AC102132, AC157903
      Consensus CDS
      CCDS89260.1
      Related
      ENSMUSP00000158252.2, ENSMUST00000236879.2
      Conserved Domains (2) summary
      sd00039
      Location:22 → 62
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:408 → 592
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      63841731..64122831
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525478.5 → XP_006525541.1  WD repeat-containing protein 7 isoform X1

      Conserved Domains (2) summary
      sd00039
      Location:22 → 62
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:408 → 592
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q920I9.3 GenPept UniProtKB/Swiss-Prot:Q920I9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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