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    Rpn1 ribophorin I [ Mus musculus (house mouse) ]

    Gene ID: 103963, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rpn1provided by MGI
    Official Full Name
    ribophorin Iprovided by MGI
    Primary source
    MGI:MGI:98084
    See related
    Ensembl:ENSMUSG00000030062 AllianceGenome:MGI:98084
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rpn-1; D6Wsu137e
    Summary
    Predicted to be involved in protein N-linked glycosylation via asparagine. Located in endoplasmic reticulum membrane and rough endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; cranium; genitourinary system; and sensory organ. Orthologous to human RPN1 (ribophorin I). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 91.8), ovary adult (RPKM 79.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rpn1 in Genome Data Viewer
    Location:
    6 D1; 6 39.13 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (88061455..88082286)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (88084473..88105304)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34872 Neighboring gene RAB7, member RAS oncogene family Neighboring gene predicted gene, 38855 Neighboring gene STARR-seq mESC enhancer starr_16574 Neighboring gene STARR-positive B cell enhancer ABC_E2195 Neighboring gene microRNA 6376 Neighboring gene predicted gene, 53293 Neighboring gene Gata2R1 erythroid cis-regulatory module Neighboring gene stem and progenitor enriched required for hematopoietic differentiation Neighboring gene predicted gene, 38856

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation. Graham DB, et al. Cell Rep, 2016 Dec 13. PMID 27974209, Free PMC Article
    2. Multiple, distant Gata2 enhancers specify temporally and tissue-specific patterning in the developing urogenital system. Khandekar M, et al. Mol Cell Biol, 2004 Dec. PMID 15542836, Free PMC Article
    3. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Harding HP, et al. Nature, 1999 Jan 21. PMID 9930704
    4. NACHO Engages N-Glycosylation ER Chaperone Pathways for α7 Nicotinic Receptor Assembly. Kweon HJ, et al. Cell Rep, 2020 Aug 11. PMID 32783947
    5. Determination of downstream targets of FGF signalling using gene trap and cDNA subtractive approaches. Tateossian H, et al. Exp Cell Res, 2004 Jan 1. PMID 14720510

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of oligosaccharyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of oligosaccharyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of oligosaccharyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in rough endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
    Names
    RPN-I
    dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit
    ribophorin-1
    NP_598694.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133933.4 → NP_598694.3  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 precursor

      See identical proteins and their annotated locations for NP_598694.3

      Status: VALIDATED

      Source sequence(s)
      AK029923, BC085483, BY308146
      Consensus CDS
      CCDS20332.1
      UniProtKB/Swiss-Prot
      Q3U985, Q91YQ5
      UniProtKB/TrEMBL
      Q3U900, Q5RKP4, Q8BMR3
      Related
      ENSMUSP00000032143.7, ENSMUST00000032143.8
      Conserved Domains (2) summary
      pfam04597
      Location:34 → 458
      Ribophorin_I; Ribophorin I
      pfam10482
      Location:520 → 590
      CtIP_N; Tumour-suppressor protein CtIP N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      88061455..88082286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91YQ5.1 GenPept UniProtKB/Swiss-Prot:Q91YQ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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