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    Mien1 migration and invasion enhancer 1 [ Mus musculus (house mouse) ]

    Gene ID: 103742, updated on 7-Apr-2024

    Summary

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    Official Symbol
    Mien1provided by MGI
    Official Full Name
    migration and invasion enhancer 1provided by MGI
    Primary source
    MGI:MGI:1913678
    See related
    Ensembl:ENSMUSG00000002580 AllianceGenome:MGI:1913678
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rdx12; 1810046J19Rik
    Summary
    Predicted to be involved in several processes, including positive regulation of cell migration; positive regulation of filopodium assembly; and response to selenium ion. Predicted to act upstream of or within apoptotic process. Located in cytosol. Is expressed in central nervous system and dorsal root ganglion. Orthologous to human MIEN1 (migration and invasion enhancer 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 66.7), duodenum adult (RPKM 55.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 D; 11 61.75 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98328534..98349056, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98437708..98458230, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98254740-98254849 Neighboring gene STARR-seq mESC enhancer starr_30667 Neighboring gene post-GPI attachment to proteins 3 Neighboring gene phenylethanolamine-N-methyltransferase Neighboring gene erb-b2 receptor tyrosine kinase 2 Neighboring gene STARR-positive B cell enhancer ABC_E5275 Neighboring gene STARR-seq mESC enhancer starr_30668 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98320467-98320833 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98320999-98321108 Neighboring gene growth factor receptor bound protein 7 Neighboring gene STARR-positive B cell enhancer ABC_E11772 Neighboring gene IKAROS family zinc finger 3 Neighboring gene predicted gene, 25106 Neighboring gene STARR-positive B cell enhancer ABC_E7058 Neighboring gene VISTA enhancer mm503 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98388491-98388674 Neighboring gene STARR-positive B cell enhancer ABC_E8880 Neighboring gene STARR-positive B cell enhancer ABC_E8450 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98412942-98413125 Neighboring gene zona pellucida binding protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SelT, SelW, SelH, and Rdx12: genomics and molecular insights into the functions of selenoproteins of a novel thioredoxin-like family. Dikiy A, et al. Biochemistry, 2007 Jun 12. PMID 17503775
    2. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Short peptides based on the conserved regions of MIEN1 protein exhibit anticancer activity by targeting the MIEN1 signaling pathway.
      Title: Short peptides based on the conserved regions of MIEN1 protein exhibit anticancer activity by targeting the MIEN1 signaling pathway.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of filopodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    migration and invasion enhancer 1
    Names
    protein C17orf37 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025559.2 → NP_079835.1  migration and invasion enhancer 1

      See identical proteins and their annotated locations for NP_079835.1

      Status: VALIDATED

      Source sequence(s)
      AK007795, BE623929, CA530220
      Consensus CDS
      CCDS25350.1
      UniProtKB/Swiss-Prot
      A2A556, Q9CQ86
      Related
      ENSMUSP00000002655.8, ENSMUST00000002655.8
      Conserved Domains (1) summary
      TIGR02174
      Location:25 → 95
      CXXU_selWTH; selT/selW/selH selenoprotein domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      98328534..98349056 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245455.1 → XP_030101315.1  migration and invasion enhancer 1 isoform X1

      UniProtKB/Swiss-Prot
      A2A556, Q9CQ86
      Conserved Domains (1) summary
      TIGR02174
      Location:25 → 95
      CXXU_selWTH; selT/selW/selH selenoprotein domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQ86.1 GenPept UniProtKB/Swiss-Prot:Q9CQ86

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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