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    Sec14l4 SEC14-like lipid binding 4 [ Mus musculus (house mouse) ]

    Gene ID: 103655, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Sec14l4provided by MGI
    Official Full Name
    SEC14-like lipid binding 4provided by MGI
    Primary source
    MGI:MGI:2144095
    See related
    Ensembl:ENSMUSG00000019368 AllianceGenome:MGI:2144095
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SPF; TAP
    Summary
    Predicted to enable lipid binding activity. Orthologous to several human genes including SEC14L4 (SEC14 like lipid binding 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 35.1), lung adult (RPKM 18.2) and 3 other tissues See more
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    Genomic context

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    See Sec14l4 in Genome Data Viewer
    Location:
    11 A1; 11 2.84 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (3981377..3998426)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (4031378..4048426)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene galactose-3-O-sulfotransferase 1 Neighboring gene predicted gene, 46265 Neighboring gene predicted gene 11954 Neighboring gene STARR-seq mESC enhancer starr_28368 Neighboring gene SEC14-like lipid binding 3 Neighboring gene predicted gene, 51935 Neighboring gene mitochondrial fission process 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. alpha-Tocopherol transfer protein inhibition is effective in the prevention of cerebral malaria in mice. Herbas MS, et al. Am J Clin Nutr, 2010 Jan. PMID 19923370
    2. Regulation of hepatic cholesterol synthesis by a novel protein (SPF) that accelerates cholesterol biosynthesis. Shibata N, et al. FASEB J, 2006 Dec. PMID 17077281
    3. Molecular cloning and characterization of cDNA for eukaryotic transcription factor S-II. Hirashima S, et al. J Biol Chem, 1988 Mar 15. PMID 3346229
    4. A HeLa-cell-encoded p21 is homologous to transcription elongation factor SII. Yeh CH, et al. Gene, 1994 Jun 10. PMID 8206389
    5. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deficiency of alpha-tocopherol in the circulation prevents cerebral malaria suggesting that this protein may be involved in early prevention of malaria.
      Title: alpha-Tocopherol transfer protein inhibition is effective in the prevention of cerebral malaria in mice.
    2. The expression of SPF in response to food deprivation and fibrate administration is reported in wild-type and knockouk mice.
      Title: Regulation of hepatic cholesterol synthesis by a novel protein (SPF) that accelerates cholesterol biosynthesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC30313

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SEC14-like protein 4
    Names
    SEC14-like 2
    SEC14-like 4
    alpha-tocopherol associated protein
    squalene transfer protein
    supernatant protein factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146013.1 → NP_666125.1  SEC14-like protein 4

      See identical proteins and their annotated locations for NP_666125.1

      Status: PROVISIONAL

      Source sequence(s)
      BC026948
      Consensus CDS
      CCDS24374.1
      UniProtKB/Swiss-Prot
      Q8R0F9
      Related
      ENSMUSP00000019512.8, ENSMUST00000019512.8
      Conserved Domains (3) summary
      smart00516
      Location:77 → 244
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      smart01100
      Location:13 → 59
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      pfam13897
      Location:284 → 379
      GOLD_2; Golgi-dynamics membrane-trafficking

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      3981377..3998426
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514437.3 → XP_006514500.1  SEC14-like protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006514500.1

      Conserved Domains (2) summary
      smart00516
      Location:23 → 190
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      pfam13897
      Location:230 → 325
      GOLD_2; Golgi-dynamics membrane-trafficking

    2. XM_006514438.3 → XP_006514501.1  SEC14-like protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006514501.1

      Conserved Domains (2) summary
      smart00516
      Location:23 → 190
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      pfam13897
      Location:230 → 325
      GOLD_2; Golgi-dynamics membrane-trafficking

    3. XM_006514439.3 → XP_006514502.1  SEC14-like protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006514502.1

      Conserved Domains (2) summary
      smart00516
      Location:23 → 190
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      pfam13897
      Location:230 → 325
      GOLD_2; Golgi-dynamics membrane-trafficking
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R0F9.1 GenPept UniProtKB/Swiss-Prot:Q8R0F9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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