Fbxw11 F-box and WD-40 domain protein 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fbxw11provided by MGI
Official Full Name: F-box and WD-40 domain protein 11provided by MGI
Primary source: MGI:MGI:2144023
See related: Ensembl:ENSMUSG00000020271 AllianceGenome:MGI:2144023
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HOS; BTRC2; BTRCP2; Fbxw1b; 2310065A07Rik
Summary: Enables ubiquitin-protein transferase activity. Contributes to ubiquitin protein ligase activity. Involved in several processes, including cellular protein metabolic process; negative regulation of NIK/NF-kappaB signaling; and positive regulation of circadian rhythm. Located in cytosol and nucleus. Part of SCF ubiquitin ligase complex. Is expressed in cap mesenchyme; early tubule; ovary; and testis. Orthologous to human FBXW11 (F-box and WD repeat domain containing 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in cerebellum adult (RPKM 24.5), whole brain E14.5 (RPKM 24.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A4; 11 19.02 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (32592595..32696816)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (32642555..32746816)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

E3 ubiquitin ligase FBXW11 as a novel inflammatory biomarker is associated with immune infiltration and NF-kappaB pathway activation in pancreatitis and pancreatic cancer.
Title: E3 ubiquitin ligase FBXW11 as a novel inflammatory biomarker is associated with immune infiltration and NF-κB pathway activation in pancreatitis and pancreatic cancer.
FBXW11 deletion alleviates Alzheimer's disease by reducing neuroinflammation and amyloid-beta plaque formation via repression of ASK1 signaling.
Title: FBXW11 deletion alleviates Alzheimer's disease by reducing neuroinflammation and amyloid-β plaque formation via repression of ASK1 signaling.
Investigated beta-TrCP function in Sertoli cells by generating mice with targeted deletion of the beta-TrCP2 gene in Sertoli cells on a background of whole-body beta-TrCP1 knockout. Loss of beta-TrCP in Sertoli cells caused infertility due to a reduction in the number of mature sperm.
Title: The ubiquitin ligase subunit β-TrCP in Sertoli cells is essential for spermatogenesis in mice.
beta-TrCP was identified as a novel interacting partner of ASK1 that is capable of ubiquitinating and degrading ASK1 through the ubiquitin-proteasome system. These findings suggest that beta-TrCP is capable of suppressing oxidative stress-induced caspase 3-dependent apoptosis through suppression of ASK1.
Title: β-TrCP-dependent degradation of ASK1 suppresses the induction of the apoptotic response by oxidative stress.
The mTOR pathway promotes cell proliferation via beta-TrCP2-dependent p19(Arf) degradation under nutrient-rich conditions.
Title: S6 Kinase- and β-TrCP2-Dependent Degradation of p19Arf Is Required for Cell Proliferation.
Data show that beta-TrCP2 and beta-TrCP1 target PER2 protein in vitro, and also show that the beta-TrCP binding site of PER2 is recognized by both beta-TrCP1 and beta-TrCP2 [beta-TrCP2].
Title: The role of {beta}-TrCP1 and {beta}-TrCP2 in circadian rhythm generation by mediating degradation of clock protein PER2.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126984 (e-PCR)
- UniSTS:208653

AA536858 (e-PCR)
- UniSTS:185869

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables dynein complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule plus-end binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
contributes_to ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in brain morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
involved_in establishment of mitotic spindle orientation	IBA Inferred from Biological aspect of Ancestor more info
involved_in germ cell development	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule organizing center organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of non-canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein destabilization	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in retrograde axonal transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info
involved_in vesicle transport along microtubule	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
part_of SCF ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
part_of microtubule associated complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: F-box/WD repeat-containing protein 11

Names: F-box and WD repeats protein beta-TrCP2; F-box and WD-40 domain protein 1B; F-box/WD repeat-containing protein 1B; homologous to Slimb protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271347.2 → NP_001258276.1 F-box/WD repeat-containing protein 11 isoform b

See identical proteins and their annotated locations for NP_001258276.1

Status: VALIDATED

Source sequence(s)

AL669844, AL669951

Consensus CDS

CCDS70157.1

UniProtKB/Swiss-Prot

Q3TGM9, Q3TLZ8, Q5SRY7, Q8BY90, Q8K022, Q923H0

UniProtKB/TrEMBL

Q8CHD5

Related

ENSMUSP00000090893.7, ENSMUST00000093205.13

Conserved Domains (4) summary

cd00200
Location:240 → 518

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:243 → 278

7WD40; WD40 repeat [structural motif]

pfam12125
Location:78 → 116

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:120 → 167

F-box-like
NM_001271348.2 → NP_001258277.1 F-box/WD repeat-containing protein 11 isoform c

See identical proteins and their annotated locations for NP_001258277.1

Status: VALIDATED

Source sequence(s)

AL669844, AL669951

Consensus CDS

CCDS70158.1

UniProtKB/TrEMBL

Q8CHD5

Related

ENSMUSP00000104991.2, ENSMUST00000109366.8

Conserved Domains (4) summary

cd00200
Location:227 → 505

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:230 → 265

7WD40; WD40 repeat [structural motif]

pfam12125
Location:65 → 103

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:107 → 154

F-box-like
NM_001271349.2 → NP_001258278.1 F-box/WD repeat-containing protein 11 isoform d

See identical proteins and their annotated locations for NP_001258278.1

Status: VALIDATED

Source sequence(s)

AL669844, AL669951

UniProtKB/TrEMBL

Q8CHD5

Conserved Domains (4) summary

cd00200
Location:206 → 484

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:209 → 244

7WD40; WD40 repeat [structural motif]

pfam12125
Location:44 → 82

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:86 → 133

F-box-like
NM_001363353.2 → NP_001350282.1 F-box/WD repeat-containing protein 11 isoform e

Status: VALIDATED

Source sequence(s)

AL669844, AL669951

UniProtKB/TrEMBL

Q8CHD5

Conserved Domains (4) summary

cd00200
Location:208 → 486

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:211 → 246

7WD40; WD40 repeat [structural motif]

pfam12125
Location:46 → 84

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:88 → 135

F-box-like
NM_001363354.2 → NP_001350283.1 F-box/WD repeat-containing protein 11 isoform f

Status: VALIDATED

Source sequence(s)

AL669844, AL669951

UniProtKB/TrEMBL

Q8CHD5

Conserved Domains (4) summary

cd00200
Location:208 → 486

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:211 → 246

7WD40; WD40 repeat [structural motif]

pfam12125
Location:46 → 84

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:88 → 135

F-box-like
NM_001363355.2 → NP_001350284.1 F-box/WD repeat-containing protein 11 isoform g

Status: VALIDATED

Source sequence(s)

AL669844, AL669951

UniProtKB/TrEMBL

Q8CHD5

Conserved Domains (4) summary

cd00200
Location:142 → 420

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:145 → 180

7WD40; WD40 repeat [structural motif]

pfam12937
Location:22 → 69

F-box-like

cl26390
Location:1 → 18

Beta-TrCP_D; D domain of beta-TrCP
NM_134015.4 → NP_598776.1 F-box/WD repeat-containing protein 11 isoform a

See identical proteins and their annotated locations for NP_598776.1

Status: VALIDATED

Source sequence(s)

AL669844, AL669951

Consensus CDS

CCDS36125.1

UniProtKB/TrEMBL

Q8CHD5

Related

ENSMUSP00000075721.8, ENSMUST00000076383.8

Conserved Domains (4) summary

cd00200
Location:261 → 539

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:264 → 299

7WD40; WD40 repeat [structural motif]

pfam12125
Location:99 → 137

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:141 → 188

F-box-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

32592595..32696816

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006514433.4 → XP_006514496.1 F-box/WD repeat-containing protein 11 isoform X1

UniProtKB/TrEMBL

Q8CHD5

Conserved Domains (4) summary

cd00200
Location:229 → 507

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:232 → 267

7WD40; WD40 repeat [structural motif]

pfam12125
Location:67 → 105

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:109 → 156

F-box-like