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    Csnk1g2 casein kinase 1, gamma 2 [ Mus musculus (house mouse) ]

    Gene ID: 103236, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Csnk1g2provided by MGI
    Official Full Name
    casein kinase 1, gamma 2provided by MGI
    Primary source
    MGI:MGI:1920014
    See related
    Ensembl:ENSMUSG00000003345 AllianceGenome:MGI:1920014
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810429I12Rik
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including Wnt signaling pathway; positive regulation of canonical Wnt signaling pathway; and protein phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Is expressed in brain; genitourinary system; and skin. Orthologous to human CSNK1G2 (casein kinase 1 gamma 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 317.9), colon adult (RPKM 106.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 C1; 10 39.72 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80458465..80476605)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80622676..80640771)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene secretory carrier membrane protein 4 Neighboring gene microRNA 6912 Neighboring gene predicted gene, 31298 Neighboring gene BTB domain containing 2 Neighboring gene predicted gene, 51810 Neighboring gene STARR-positive B cell enhancer ABC_E3899 Neighboring gene MAP kinase-interacting serine/threonine kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-interacting kinase 3. Li D, et al. Elife, 2020 Nov 18. PMID 33206046, Free PMC Article
    2. Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase. Mishra SK, et al. Oncogene, 2004 May 27. PMID 15077195
    3. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    4. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
    5. A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Thompson CL, et al. Neuron, 2014 Jul 16. PMID 24952961, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CKI-gamma2 could further potentiate the ER corepressive function of MTA1s. Kinase dead CK1-gamma2 could not repress estrogen-induced ER transactivation functions.
      Title: Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (3)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    casein kinase I isoform gamma-2; casein kinase I
    Names
    CKI-gamma 2
    NP_001153063.1
    NP_598763.1
    XP_006513074.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159591.1 → NP_001153063.1  casein kinase I isoform gamma-2 isoform 2

      See identical proteins and their annotated locations for NP_001153063.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR exon and lacks an in-frame internal segment in the CDS, as compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK132871, AK152413, CF612914
      Consensus CDS
      CCDS48638.1
      UniProtKB/Swiss-Prot
      Q8BVP5
      Related
      ENSMUSP00000082560.6, ENSMUST00000085435.7
      Conserved Domains (2) summary
      cd14126
      Location:45 → 332
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:332 → 374
      CK1gamma_C; Casein kinase 1 gamma C terminal

    2. NM_134002.2 → NP_598763.1  casein kinase I isoform gamma-2 isoform 1

      See identical proteins and their annotated locations for NP_598763.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC152410, AK077076, AK132871, AK152413, CF612914
      Consensus CDS
      CCDS24029.1
      UniProtKB/TrEMBL
      Q99K78
      Related
      ENSMUSP00000078706.7, ENSMUST00000079773.14
      Conserved Domains (3) summary
      COG0515
      Location:45 → 356
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14126
      Location:45 → 359
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:359 → 401
      CK1gamma_C; Casein kinase 1 gamma C terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      80458465..80476605
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513011.3 → XP_006513074.1  casein kinase I isoform X1

      See identical proteins and their annotated locations for XP_006513074.1

      UniProtKB/Swiss-Prot
      Q8BVP5
      Conserved Domains (2) summary
      cd14126
      Location:45 → 332
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:332 → 374
      CK1gamma_C; Casein kinase 1 gamma C terminal

    RNA

    1. XR_001779401.2 RNA Sequence

    2. XR_380333.4 RNA Sequence

    3. XR_003948572.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BVP5.1 GenPept UniProtKB/Swiss-Prot:Q8BVP5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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