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    Slc6a15 solute carrier family 6 (neurotransmitter transporter), member 15 [ Mus musculus (house mouse) ]

    Gene ID: 103098, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Slc6a15provided by MGI
    Official Full Name
    solute carrier family 6 (neurotransmitter transporter), member 15provided by MGI
    Primary source
    MGI:MGI:2143484
    See related
    Ensembl:ENSMUSG00000019894 AllianceGenome:MGI:2143484
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    v7-3
    Summary
    Enables proline:sodium symporter activity. Involved in leucine transport and proline transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in alimentary system; central nervous system; dorsal root ganglion; metanephros; and sensory organ. Orthologous to human SLC6A15 (solute carrier family 6 member 15). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E18 (RPKM 15.2), cerebellum adult (RPKM 9.1) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 D1; 10 53.98 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (103203320..103255240)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (103367808..103419379)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34298 Neighboring gene ALX homeobox 1 Neighboring gene leucine-rich repeats and IQ motif containing 1 Neighboring gene predicted gene, 25376 Neighboring gene STARR-seq mESC enhancer starr_27747 Neighboring gene STARR-seq mESC enhancer starr_27748 Neighboring gene STARR-seq mESC enhancer starr_27749 Neighboring gene STARR-seq mESC enhancer starr_27750 Neighboring gene STARR-seq mESC enhancer starr_27751 Neighboring gene RIKEN cDNA 6430590A10 gene Neighboring gene STARR-seq mESC enhancer starr_27752 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene STARR-seq mESC enhancer starr_27753 Neighboring gene predicted gene, 25143

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of the psychiatric risk factor SLC6A15 is associated with increased metabolic functions in primary hippocampal neurons. Schraut KG, et al. Eur J Neurosci, 2021 Jan. PMID 33007132
    2. SLC6A15, a novel stress vulnerability candidate, modulates anxiety and depressive-like behavior: involvement of the glutamatergic system. Santarelli S, et al. Stress, 2016. PMID 26585320
    3. The amino acid transporter SLC6A15 is a regulator of hippocampal neurochemistry and behavior. Santarelli S, et al. J Psychiatr Res, 2015 Sep. PMID 26228428
    4. Involvement of the neutral amino acid transporter SLC6A15 and leucine in obesity-related phenotypes. Drgonova J, et al. PLoS One, 2013. PMID 24023709, Free PMC Article
    5. B(0)AT2 (SLC6A15) is localized to neurons and astrocytes, and is involved in mediating the effect of leucine in the brain. Hägglund MG, et al. PLoS One, 2013. PMID 23505546, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of the psychiatric risk factor SLC6A15 is associated with increased metabolic functions in primary hippocampal neurons.
      Title: Loss of the psychiatric risk factor SLC6A15 is associated with increased metabolic functions in primary hippocampal neurons.
    2. Our study demonstrates a role for reduced Slc6a15, a neutral amino acid transporter, in nucleus accumbens (NAc) in depression and stress susceptibility. The reduction of Slc6a15 occurs selectively in the NAc D2-neurons. Genetic reduction of Slc6a15 induces susceptibility to a subthreshold stress, while genetic overexpression in D2-neurons prevents social avoidance after chronic social defeat stress.
      Title: Reduced Slc6a15 in Nucleus Accumbens D2-Neurons Underlies Stress Susceptibility.
    3. Slc6a15 plays a role in modulating emotional behavior, possibly mediated by its impact on glutamatergic neurotransmission.
      Title: SLC6A15, a novel stress vulnerability candidate, modulates anxiety and depressive-like behavior: involvement of the glutamatergic system.
    4. SLC6A15 regulates the activity of the brain glutamatergic system through the proline-glutamate biosynthesis pathway, affecting hippocampal neurochemistry and consequently behavior.
      Title: The amino acid transporter SLC6A15 is a regulator of hippocampal neurochemistry and behavior.
    5. Slc6a15 knockout mice demonstrate only modest alterations in rotarod performance with aging and lack reproducible alterations in other motor, memory, anxiety or olfactory tests
      Title: Deletion of v7-3 (SLC6A15) transporter allows assessment of its roles in synaptosomal proline uptake, leucine uptake and behaviors.
    6. The structure and function of B0AT2 are reported.
      Title: The orphan transporter v7-3 (slc6a15) is a Na+-dependent neutral amino acid transporter (B0AT2).
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables branched-chain amino acid:sodium symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables branched-chain amino acid:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neutral L-amino acid:sodium symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables neutral L-amino acid:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proline:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proline:sodium symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-leucine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-leucine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neurotransmitter transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neutral amino acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neutral amino acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proline transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sodium-dependent neutral amino acid transporter B(0)AT2
    Names
    B0AT2 protein
    orphan sodium- and chloride-dependent neurotransmitter transporter NTT73
    orphan transporter v7-3
    solute carrier family 6 member 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252330.1 → NP_001239259.1  sodium-dependent neutral amino acid transporter B(0)AT2

      See identical proteins and their annotated locations for NP_001239259.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (b) differs in the 5' UTR, compared to variant c. Variants a, b and c encode the same protein.
      Source sequence(s)
      AW124505, BC076593
      Consensus CDS
      CCDS24156.1
      UniProtKB/Swiss-Prot
      Q333Y0, Q8BG16
      Related
      ENSMUSP00000136676.2, ENSMUST00000179636.3
      Conserved Domains (1) summary
      cd11522
      Location:61 → 640
      SLC6sbd_SBAT1; Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain

    2. NM_001358821.1 → NP_001345750.1  sodium-dependent neutral amino acid transporter B(0)AT2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (c) represents the longest transcript. Variants a, b and c encode the same protein.
      Source sequence(s)
      AW124505, BC076593, CF736974, CN460271
      Consensus CDS
      CCDS24156.1
      UniProtKB/Swiss-Prot
      Q333Y0, Q8BG16
      Conserved Domains (1) summary
      cd11522
      Location:61 → 640
      SLC6sbd_SBAT1; Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain

    3. NM_175328.3 → NP_780537.1  sodium-dependent neutral amino acid transporter B(0)AT2

      See identical proteins and their annotated locations for NP_780537.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (a) differs in the 5' UTR, compared to variant c. Variants a, b and c encode the same protein.
      Source sequence(s)
      AW124505, AY149280, BC076593
      Consensus CDS
      CCDS24156.1
      UniProtKB/Swiss-Prot
      Q333Y0, Q8BG16
      Related
      ENSMUSP00000073829.5, ENSMUST00000074204.12
      Conserved Domains (1) summary
      cd11522
      Location:61 → 640
      SLC6sbd_SBAT1; Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      103203320..103255240
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155449.1 → XP_036011342.1  sodium-dependent neutral amino acid transporter B(0)AT2 isoform X1

      UniProtKB/Swiss-Prot
      Q333Y0, Q8BG16
      Conserved Domains (1) summary
      cd11522
      Location:61 → 640
      SLC6sbd_SBAT1; Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain

    2. XM_006512983.5 → XP_006513046.1  sodium-dependent neutral amino acid transporter B(0)AT2 isoform X1

      See identical proteins and their annotated locations for XP_006513046.1

      UniProtKB/Swiss-Prot
      Q333Y0, Q8BG16
      Conserved Domains (1) summary
      cd11522
      Location:61 → 640
      SLC6sbd_SBAT1; Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain

    3. XM_006512984.5 → XP_006513047.1  sodium-dependent neutral amino acid transporter B(0)AT2 isoform X1

      See identical proteins and their annotated locations for XP_006513047.1

      UniProtKB/Swiss-Prot
      Q333Y0, Q8BG16
      Conserved Domains (1) summary
      cd11522
      Location:61 → 640
      SLC6sbd_SBAT1; Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BG16.1 GenPept UniProtKB/Swiss-Prot:Q8BG16

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