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    Ezhip EZH inhibitory protein [ Mus musculus (house mouse) ]

    Gene ID: 102991, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ezhipprovided by MGI
    Official Full Name
    EZH inhibitory proteinprovided by MGI
    Primary source
    MGI:MGI:2147968
    See related
    Ensembl:ENSMUSG00000073294 AllianceGenome:MGI:2147968
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KIP75
    Summary
    Acts upstream of or within negative regulation of histone H3-K27 trimethylation and oocyte development. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in axial skeleton and rib. Orthologous to human EZHIP (EZH inhibitory protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in ovary adult (RPKM 10.7) and testis adult (RPKM 0.7) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X A1.1; X 2.7 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (5993272..5995474, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (6081218..6083420, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 26618 Neighboring gene STARR-seq mESC enhancer starr_46653 Neighboring gene nudix hydrolase 11 Neighboring gene ribosomal protein L19, pseudogene 12 Neighboring gene nuclear encoded rRNA 5S 2 Neighboring gene STARR-seq mESC enhancer starr_46654 Neighboring gene nudix hydrolase 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism. Jain SU, et al. Nat Commun, 2019 May 13. PMID 31086175, Free PMC Article
    2. EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells. Ragazzini R, et al. Nat Commun, 2019 Aug 26. PMID 31451685, Free PMC Article
    3. CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism. Piunti A, et al. Sci Adv, 2019 Jul. PMID 31281901, Free PMC Article
    4. Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator. Maier VK, et al. Mol Cell Proteomics, 2015 Jun. PMID 25680957, Free PMC Article
    5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deletion of Ezhip (EZH inhibitory protein) in mice leads to a global increase in H3K27me2/3 deposition both during spermatogenesis and at late stages of oocyte maturation. This does not affect the initial number of follicles but is associated with a reduction of follicles in aging. Study uncovers Ezhip as a regulator of chromatin landscape in gametes.
      Title: EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells.
    2. Study revealed that CXORF67 contains a highly conserved "K27M-like" sequence that is necessary and sufficient to inhibit PRC2 activity and reduce cellular H3K27me3 levels. Biochemical and cell-based studies demonstrate that CXORF67 functions as a K27M-like peptidyl inhibitor of PRC2. Therefore, study propose the name EZHIP (Enhancer of Zeste Homologs Inhibitory Protein) as a more descriptive for the function of CXORF67.
      Title: PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117813

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone methyltransferase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epigenetic regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within oocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    EZH inhibitory protein
    Names
    K27M-like inhibitor of PRC2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033211.3 → NP_001028383.2  EZH inhibitory protein isoform 2

      See identical proteins and their annotated locations for NP_001028383.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal segment in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      BX649475
      Consensus CDS
      CCDS52982.1
      UniProtKB/TrEMBL
      Q3UWZ4
      Related
      ENSMUSP00000099222.4, ENSMUST00000101698.4
      Conserved Domains (1) summary
      PRK06995
      Location:174 → 263
      flhF; flagellar biosynthesis protein FlhF

    2. NM_001166433.1 → NP_001159905.1  EZH inhibitory protein isoform 1

      See identical proteins and their annotated locations for NP_001159905.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      BX649475
      Consensus CDS
      CCDS52981.1
      UniProtKB/Swiss-Prot
      B1B0V2, Q3TL73, Q3UWZ4, Q497U5
      Related
      ENSMUSP00000114041.2, ENSMUST00000117544.2
      Conserved Domains (2) summary
      PHA03247
      Location:128 → 502
      PHA03247; large tegument protein UL36; Provisional
      PRK06995
      Location:295 → 384
      flhF; flagellar biosynthesis protein FlhF

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      5993272..5995474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1B0V2.1 GenPept UniProtKB/Swiss-Prot:B1B0V2

    Gene LinkOut

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