Cd276 CD276 antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd276provided by MGI
Official Full Name: CD276 antigenprovided by MGI
Primary source: MGI:MGI:2183926
See related: Ensembl:ENSMUSG00000035914 AllianceGenome:MGI:2183926
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B7h3; B7-H3; B7RP-2; 6030411F23Rik
Summary: Enables identical protein binding activity and signaling receptor binding activity. Acts upstream of or within several processes, including positive regulation of osteoblast differentiation; regulation of T cell proliferation; and regulation of cytokine production. Located in external side of plasma membrane. Is expressed in several structures, including embryo endoderm; genitourinary system; hemolymphoid system; liver; and musculoskeletal system. Orthologous to human CD276 (CD276 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in limb E14.5 (RPKM 25.4), CNS E14 (RPKM 11.9) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 B; 9 31.79 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (58431581..58463437, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (58524300..58555033, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD276-dependent efferocytosis by tumor-associated macrophages promotes immune evasion in bladder cancer.
Title: CD276-dependent efferocytosis by tumor-associated macrophages promotes immune evasion in bladder cancer.
CD276 promotes epithelial-mesenchymal transition in esophageal squamous cell carcinoma through the TGF-beta/SMAD signaling.
Title: CD276 promotes epithelial-mesenchymal transition in esophageal squamous cell carcinoma through the TGF-β/SMAD signaling.
Gastric cancer mesenchymal stem cells promote tumor glycolysis and chemoresistance by regulating B7H3 in gastric cancer cells.
Title: Gastric cancer mesenchymal stem cells promote tumor glycolysis and chemoresistance by regulating B7H3 in gastric cancer cells.
B7-H3 promotes angiogenesis in rheumatoid arthritis.
Title: B7-H3 promotes angiogenesis in rheumatoid arthritis.
Tumor-expressed B7-H3 promotes vasculogenic mimicry formation rather than angiogenesis in non-small cell lung cancer.
Title: Tumor-expressed B7-H3 promotes vasculogenic mimicry formation rather than angiogenesis in non-small cell lung cancer.
EBV-Upregulated B7-H3 Inhibits NK cell-Mediated Antitumor Function and Contributes to Nasopharyngeal Carcinoma Progression.
Title: EBV-Upregulated B7-H3 Inhibits NK cell-Mediated Antitumor Function and Contributes to Nasopharyngeal Carcinoma Progression.
Decreased B7-H3 promotes unexplained recurrent miscarriage via RhoA/ROCK2 signaling pathway and regulates the secretion of decidual NK cellsdagger.
Title: Decreased B7-H3 promotes unexplained recurrent miscarriage via RhoA/ROCK2 signaling pathway and regulates the secretion of decidual NK cells†.
Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer.
Title: Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer.
B7-H3 blockade decreases macrophage inflammatory response and alleviates clinical symptoms of arthritis.
Title: B7-H3 blockade decreases macrophage inflammatory response and alleviates clinical symptoms of arthritis.
B7H3 expression and significance in idiopathic pulmonary fibrosis.
Title: B7H3 expression and significance in idiopathic pulmonary fibrosis.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (11) 1 citation
Endonuclease-mediated (7)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B7h3 (e-PCR), detects polymorphism
- UniSTS:463442

AU016588 (e-PCR)
- UniSTS:179922

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of interleukin-2 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of type II interferon production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-2 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokine production	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of immune response	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CD276 antigen

Names: B7 homolog 3; costimulatory molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001424677.1 → NP_001411606.1 CD276 antigen isoform 1 precursor

Status: VALIDATED

Source sequence(s)

CT030640
NM_001424678.1 → NP_001411607.1 CD276 antigen isoform 1 precursor

Status: VALIDATED

Source sequence(s)

CT030640
NM_001424679.1 → NP_001411608.1 CD276 antigen isoform 2 precursor

Status: VALIDATED

Source sequence(s)

CT030640

UniProtKB/Swiss-Prot

Q8VE98

UniProtKB/TrEMBL

A6MDC5
NM_001424680.1 → NP_001411609.1 CD276 antigen isoform 3 precursor

Status: VALIDATED

Source sequence(s)

CT030640
NM_001424681.1 → NP_001411610.1 CD276 antigen isoform 4 precursor

Status: VALIDATED

Source sequence(s)

CT030640
NM_133983.5 → NP_598744.1 CD276 antigen isoform 2 precursor

See identical proteins and their annotated locations for NP_598744.1

Status: VALIDATED

Source sequence(s)

CT030640

Consensus CDS

CCDS23244.1

UniProtKB/Swiss-Prot

Q8VE98

UniProtKB/TrEMBL

A6MDC5

Related

ENSMUSP00000129418.2, ENSMUST00000165365.3

Conserved Domains (3) summary

cd00098
Location:149 → 235

IgC; Immunoglobulin Constant domain

smart00410
Location:37 → 138

IG_like; Immunoglobulin like

cl11960
Location:44 → 139

Ig; Immunoglobulin domain