Snx19 sorting nexin 19 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Snx19provided by MGI
Official Full Name: sorting nexin 19provided by MGI
Primary source: MGI:MGI:1921581
See related: Ensembl:ENSMUSG00000031993 AllianceGenome:MGI:1921581
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0254; 3526401K03Rik
Summary: Enables phosphatidylinositol-3-phosphate binding activity. Acts upstream of or within chondrocyte differentiation; dense core granule maturation; and insulin secretion. Located in early endosome membrane. Is expressed in limb; tibia; and vertebral cartilage condensation. Orthologous to human SNX19 (sorting nexin 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in cerebellum adult (RPKM 7.0), subcutaneous fat pad adult (RPKM 5.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A4; 9 16.04 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (30338284..30378437)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (30426988..30467141)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SNX19 and SNX14 PX domains reveal key differences in spatial control of RGS-PX proteins in cell signaling and trafficking.
Title: Structural basis for different phosphoinositide specificities of the PX domains of sorting nexins regulating G-protein signaling.
The ATDC5-C2ER cell line system can be used for efficient monitoring of chondrogenic differentiation by fluorescence analysis. A novel chondrogenic factor (SNX19) is identified for elucidating the molecular network of chondrogenic differentiation.
Title: Screening of chondrogenic factors with a real-time fluorescence-monitoring cell line ATDC5-C2ER: identification of sorting nexin 19 as a novel factor.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chondrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dense core granule maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dense core granule maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within exocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sorting nexin-19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028874.2 → NP_083150.1 sorting nexin-19

See identical proteins and their annotated locations for NP_083150.1

Status: PROVISIONAL

Source sequence(s)

AC160339, CU024910

Consensus CDS

CCDS22944.1

UniProtKB/Swiss-Prot

Q3TQ83, Q6P4T1, Q80U53

Related

ENSMUSP00000131895.2, ENSMUST00000164099.3

Conserved Domains (3) summary

cd06893
Location:537 → 664

PX_SNX19; The phosphoinositide binding Phox Homology domain of Sorting Nexin 19

smart00313
Location:95 → 273

PXA; Domain associated with PX domains

pfam08628
Location:850 → 950

Nexin_C; Sorting nexin C terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

30338284..30378437

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017313068.2 → XP_017168557.1 sorting nexin-19 isoform X4

Conserved Domains (2) summary

cd06893
Location:537 → 664

PX_SNX19; The phosphoinositide binding Phox Homology domain of Sorting Nexin 19

smart00313
Location:95 → 273

PXA; Domain associated with PX domains
XM_030243948.2 → XP_030099808.1 sorting nexin-19 isoform X1

Conserved Domains (3) summary

cd06893
Location:537 → 664

PX_SNX19; The phosphoinositide binding Phox Homology domain of Sorting Nexin 19

smart00313
Location:95 → 273

PXA; Domain associated with PX domains

pfam08628
Location:850 → 951

Nexin_C; Sorting nexin C terminal
XM_006509906.5 → XP_006509969.1 sorting nexin-19 isoform X5

Conserved Domains (2) summary

cd06893
Location:537 → 664

PX_SNX19; The phosphoinositide binding Phox Homology domain of Sorting Nexin 19

smart00313
Location:95 → 273

PXA; Domain associated with PX domains
XM_030243950.1 → XP_030099810.1 sorting nexin-19 isoform X3

Conserved Domains (2) summary

cd06893
Location:537 → 664

PX_SNX19; The phosphoinositide binding Phox Homology domain of Sorting Nexin 19

smart00313
Location:95 → 273

PXA; Domain associated with PX domains
XM_030243951.1 → XP_030099811.1 sorting nexin-19 isoform X6

Conserved Domains (2) summary

cd06893
Location:537 → 664

PX_SNX19; The phosphoinositide binding Phox Homology domain of Sorting Nexin 19

smart00313
Location:95 → 273

PXA; Domain associated with PX domains
XM_030243949.2 → XP_030099809.1 sorting nexin-19 isoform X2

Conserved Domains (2) summary

cd06893
Location:537 → 664

PX_SNX19; The phosphoinositide binding Phox Homology domain of Sorting Nexin 19

smart00313
Location:95 → 273

PXA; Domain associated with PX domains