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    Ano10 anoctamin 10 [ Mus musculus (house mouse) ]

    Gene ID: 102566, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Ano10provided by MGI
    Official Full Name
    anoctamin 10provided by MGI
    Primary source
    MGI:MGI:2143103
    See related
    Ensembl:ENSMUSG00000037949 AllianceGenome:MGI:2143103
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmem16k
    Summary
    This gene encodes a member of the anoctamin family, which in mammals is comprised of 10 members. Anoctamin proteins are proposed to have eight transmembrane domains with both termini facing the cytoplasm and a C-terminal domain of unknown function. While some members have been characterized as calcium-activated chloride channels, this protein is reported to inhibit anion conductance. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Dec 2012]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 24.2), subcutaneous fat pad adult (RPKM 23.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 F4; 9 72.94 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (122004958..122123440, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (122175874..122294444, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39465 Neighboring gene predicted gene, 39464 Neighboring gene STARR-seq mESC enhancer starr_25542 Neighboring gene STARR-seq mESC enhancer starr_25543 Neighboring gene SNF related kinase Neighboring gene predicted gene, 57550 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:122142092-122142320 Neighboring gene STARR-seq mESC enhancer starr_25545 Neighboring gene microRNA 8106 Neighboring gene STARR-positive B cell enhancer ABC_E574 Neighboring gene predicted gene, 26797 Neighboring gene predicted gene, 35289

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TMEM16K is an interorganelle regulator of endosomal sorting. Petkovic M, et al. Nat Commun, 2020 Jul 3. PMID 32620747, Free PMC Article
    2. Predominant localization of phosphatidylserine at the cytoplasmic leaflet of the ER, and its TMEM16K-dependent redistribution. Tsuji T, et al. Proc Natl Acad Sci U S A, 2019 Jul 2. PMID 31217287, Free PMC Article
    3. Cellular defects by deletion of ANO10 are due to deregulated local calcium signaling. Wanitchakool P, et al. Cell Signal, 2017 Jan. PMID 27838374
    4. Anoctamins support calcium-dependent chloride secretion by facilitating calcium signaling in adult mouse intestine. Schreiber R, et al. Pflugers Arch, 2015 Jun. PMID 24974903
    5. Expression and functional significance of the Ca(2+)-activated Cl(-) channel ANO6 in dendritic cells. Szteyn K, et al. Cell Physiol Biochem, 2012. PMID 23159814

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TMEM16K is an interorganelle regulator of endosomal sorting.
      Title: TMEM16K is an interorganelle regulator of endosomal sorting.
    2. mediates Ca2+-dependent phosphatidylserine scrambling in the endoplasmic reticulum
      Title: Predominant localization of phosphatidylserine at the cytoplasmic leaflet of the ER, and its TMEM16K-dependent redistribution.
    3. mutations in ANO10 cause cellular defects and genetic disorders through deranged local Ca(2+) signaling.
      Title: Cellular defects by deletion of ANO10 are due to deregulated local calcium signaling.
    4. Ano10 is essential for Ca2+-dependent Cl- secretion in jejunum.
      Title: Anoctamins support calcium-dependent chloride secretion by facilitating calcium signaling in adult mouse intestine.
    5. during mouse cephalic development: detected in subventricular zone and differentiating fields, In organs developing through epithelial-mesenchymal interactions, such as the palate, tooth and tongue
      Title: Expression patterns of the Tmem16 gene family during cephalic development in the mouse.
    6. Data show the expression of Tmem16k during murine embryogenesis with an emphasis on the respiratory, digestive, skeletal, and integumentary systems.
      Title: Expression of TMEM16 paralogs during murine embryogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC106272

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium-activated cation channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables intracellularly calcium-gated chloride channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables phospholipid scramblase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monoatomic cation transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    anoctamin-10
    Names
    transmembrane protein 16K

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271873.2 → NP_001258802.1  anoctamin-10 isoform 2

      See identical proteins and their annotated locations for NP_001258802.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame acceptor splice site in the coding region, compared to variant 1. The resulting isoform (2) spans the membrane six times (rather than eight as in isoform 1) and is shorter than isoform 1.
      Source sequence(s)
      AC120394, AC121264
      Consensus CDS
      CCDS90687.1
      UniProtKB/Swiss-Prot
      Q8BH79
      Related
      ENSMUSP00000151189.2, ENSMUST00000214409.2
      Conserved Domains (1) summary
      pfam04547
      Location:197 → 570
      Anoctamin; Calcium-activated chloride channel

    2. NM_001421547.1 → NP_001408476.1  anoctamin-10 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC121264

    3. NM_001421549.1 → NP_001408478.1  anoctamin-10 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC120394, AC121264

    4. NM_001421551.1 → NP_001408480.1  anoctamin-10 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC121264

    5. NM_001421552.1 → NP_001408481.1  anoctamin-10 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC120394, AC121264

    6. NM_133979.4 → NP_598740.1  anoctamin-10 isoform 1

      See identical proteins and their annotated locations for NP_598740.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC120394, AC121264
      Consensus CDS
      CCDS23645.1
      UniProtKB/Swiss-Prot
      Q4FZD2, Q8BH79, Q8BMS8, Q8BV74, Q8BW67, Q8R0U0, Q99LP0
      Related
      ENSMUSP00000045214.3, ENSMUST00000042546.4
      Conserved Domains (1) summary
      pfam04547
      Location:200 → 628
      Anoctamin; Calcium-activated chloride channel

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      122004958..122123440 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BH79.1 GenPept UniProtKB/Swiss-Prot:Q8BH79

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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