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    Imp3 IMP3, U3 small nucleolar ribonucleoprotein [ Mus musculus (house mouse) ]

    Gene ID: 102462, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Imp3provided by MGI
    Official Full Name
    IMP3, U3 small nucleolar ribonucleoproteinprovided by MGI
    Primary source
    MGI:MGI:1916119
    See related
    Ensembl:ENSMUSG00000032288 AllianceGenome:MGI:1916119
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1190002L16Rik
    Summary
    Predicted to enable snoRNA binding activity. Acts upstream of or within rRNA processing. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of Mpp10 complex and small-subunit processome. Orthologous to human IMP3 (IMP U3 small nucleolar ribonucleoprotein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human all
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    Genomic context

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    Location:
    9 B; 9 30.53 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (56844784..56845682)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (56937500..56938398)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10548 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56776219-56776328 Neighboring gene sorting nexin 33 Neighboring gene STARR-positive B cell enhancer ABC_E1386 Neighboring gene predicted gene, 19936 Neighboring gene STARR-positive B cell enhancer ABC_E3831 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56798396-56798654 Neighboring gene snurportin 1 Neighboring gene STARR-seq mESC enhancer starr_24215 Neighboring gene protein tyrosine phosphatase, non-receptor type 9 Neighboring gene predicted gene 10658

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. IMP3 promotes re-endothelialization after arterial injury via increasing stability of VEGF mRNAhv. Zhou X, et al. J Cell Mol Med, 2022 Apr. PMID 35315195, Free PMC Article
    2. Up-regulation of Imp3 confers in vivo tumorigenicity on murine osteosarcoma cells. Ueki A, et al. PLoS One, 2012. PMID 23226335, Free PMC Article
    3. The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes. Granneman S, et al. Nucleic Acids Res, 2003 Apr 1. PMID 12655004, Free PMC Article
    4. Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins. Lang B, et al. Nucleic Acids Res, 2021 Jul 9. PMID 34133714, Free PMC Article
    5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Imp3 as a key regulator of stem-like tumorigenic characteristics in osteosarcoma cells
      Title: Up-regulation of Imp3 confers in vivo tumorigenicity on murine osteosarcoma cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within rRNA processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ribosomal small subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Mpp10 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Mpp10 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of preribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    U3 small nucleolar ribonucleoprotein protein IMP3
    Names
    IMP3, U3 small nucleolar ribonucleoprotein, homolog
    U3 snoRNP protein 3 homolog
    U3 snoRNP protein IMP3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133976.2 → NP_598737.1  U3 small nucleolar ribonucleoprotein protein IMP3

      See identical proteins and their annotated locations for NP_598737.1

      Status: PROVISIONAL

      Source sequence(s)
      BC009145
      Consensus CDS
      CCDS23213.1
      UniProtKB/Swiss-Prot
      Q921Y2
      Related
      ENSMUSP00000034827.9, ENSMUST00000034827.10
      Conserved Domains (2) summary
      COG0522
      Location:1 → 168
      RpsD; Ribosomal protein S4 or related protein [Translation, ribosomal structure and biogenesis]
      pfam01479
      Location:109 → 155
      S4; S4 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      56844784..56845682
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q921Y2.1 GenPept UniProtKB/Swiss-Prot:Q921Y2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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