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    Xylb xylulokinase homolog (H. influenzae) [ Mus musculus (house mouse) ]

    Gene ID: 102448, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Xylbprovided by MGI
    Official Full Name
    xylulokinase homolog (H. influenzae)provided by MGI
    Primary source
    MGI:MGI:2142985
    See related
    Ensembl:ENSMUSG00000035769 AllianceGenome:MGI:2142985
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable xylulokinase activity. Predicted to be involved in phosphorylation and xylulose metabolic process. Predicted to be active in cytosol. Orthologous to human XYLB (xylulokinase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in kidney adult (RPKM 57.9), liver adult (RPKM 23.4) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 F3; 9 71.33 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (119186447..119222863)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (119357381..119393797)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11425 Neighboring gene myeloid differentiation primary response gene 88 Neighboring gene acetyl-Coenzyme A acyltransferase 1A Neighboring gene predicted gene, 53515 Neighboring gene activin receptor IIB

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structure and function of human xylulokinase, an enzyme with important roles in carbohydrate metabolism. Bunker RD, et al. J Biol Chem, 2013 Jan 18. PMID 23179721, Free PMC Article
    2. An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo. Man JCK, et al. Nat Commun, 2019 Oct 30. PMID 31666509, Free PMC Article
    3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables D-xylulokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables D-xylulokinase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within D-xylose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in D-xylose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within carbohydrate phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within glucuronate catabolic process to xylulose 5-phosphate IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in glucuronate catabolic process to xylulose 5-phosphate ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xylulose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xylulose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    xylulose kinase
    NP_001028381.1
    NP_001186497.1
    NP_001346628.1
    XP_030099799.1
    XP_030099800.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033209.3 → NP_001028381.1  xylulose kinase isoform 1

      See identical proteins and their annotated locations for NP_001028381.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AK143476, AK165759
      Consensus CDS
      CCDS23614.1
      UniProtKB/Swiss-Prot
      B2RR66, Q3TNA1, Q8R156
      UniProtKB/TrEMBL
      Q66JV3
      Related
      ENSMUSP00000047254.9, ENSMUST00000039610.10
      Conserved Domains (2) summary
      PLN02669
      Location:26 → 549
      PLN02669; xylulokinase
      cd07776
      Location:24 → 494
      FGGY_D-XK_euk; eukaryotic D-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases

    2. NM_001199568.1 → NP_001186497.1  xylulose kinase isoform 2

      See identical proteins and their annotated locations for NP_001186497.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences, one of which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AK143476, AK164186, AK165759
      UniProtKB/TrEMBL
      Q3TMS3
      Conserved Domains (1) summary
      cl17037
      Location:1 → 261
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    3. NM_001359699.1 → NP_001346628.1  xylulose kinase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks a 5' exon which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AC128702, AC166052
      UniProtKB/TrEMBL
      Q66JV3
      Conserved Domains (1) summary
      cd07776
      Location:1 → 401
      FGGY_D-XK_euk; eukaryotic D-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      119186447..119222863
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243939.1 → XP_030099799.1  xylulose kinase isoform X1

      UniProtKB/TrEMBL
      Q66JV3
      Conserved Domains (1) summary
      cd07776
      Location:1 → 401
      FGGY_D-XK_euk; eukaryotic D-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases

    2. XM_030243940.1 → XP_030099800.1  xylulose kinase isoform X2

      UniProtKB/TrEMBL
      Q3TMS3
      Related
      ENSMUST00000213383.2
      Conserved Domains (1) summary
      cl17037
      Location:1 → 261
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TNA1.1 GenPept UniProtKB/Swiss-Prot:Q3TNA1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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