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    Lars2 leucyl-tRNA synthetase, mitochondrial [ Mus musculus (house mouse) ]

    Gene ID: 102436, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Lars2provided by MGI
    Official Full Name
    leucyl-tRNA synthetase, mitochondrialprovided by MGI
    Primary source
    MGI:MGI:2142973
    See related
    Ensembl:ENSMUSG00000035202 AllianceGenome:MGI:2142973
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LEURS; Kiaa0028
    Summary
    Predicted to enable leucine-tRNA ligase activity. Predicted to be involved in leucyl-tRNA aminoacylation and mitochondrial translation. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in pancreas epithelium. Human ortholog(s) of this gene implicated in Perrault syndrome. Orthologous to human LARS2 (leucyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cortex adult (RPKM 1105.1), placenta adult (RPKM 827.6) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 F4; 9 73.92 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (123196001..123291731)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (123366927..123462675)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 158 Neighboring gene STARR-seq mESC enhancer starr_25561 Neighboring gene STARR-seq mESC enhancer starr_25562 Neighboring gene sterol carrier protein 2, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_25564 Neighboring gene STARR-seq mESC enhancer starr_25565 Neighboring gene STARR-positive B cell enhancer mm9_chr9:123275808-123276108 Neighboring gene predicted gene, 46137 Neighboring gene STARR-seq mESC enhancer starr_25567 Neighboring gene predicted gene, 40586 Neighboring gene LIM domains containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E5115 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:123428421-123428574

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel noncoding RNA rescues mutant SOD1-mediated cell death. Chang Y, et al. FASEB J, 2008 Mar. PMID 17957031
    2. Leucine-tRNA-synthase-2-expressing B cells contribute to colorectal cancer immunoevasion. Wang Z, et al. Immunity, 2022 Jun 14. PMID 35659337
    3. Deficiency of the bZIP transcription factors Mafg and Mafk causes misexpression of genes in distinct pathways and results in lens embryonic developmental defects. Patel SD, et al. Front Cell Dev Biol, 2022. PMID 36092713, Free PMC Article
    4. Comparative human/murine sequence analysis of the common eliminated region 1 from human 3p21.3. Kiss H, et al. Mamm Genome, 2002 Nov. PMID 12461651
    5. Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice. Jung H, et al. Nat Neurosci, 2018 Sep. PMID 30104731

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Leucine-tRNA-synthase-2-expressing B cells contribute to colorectal cancer immunoevasion.
      Title: Leucine-tRNA-synthase-2-expressing B cells contribute to colorectal cancer immunoevasion.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA editing activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables leucine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables leucine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in leucyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leucyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable leucine--tRNA ligase, mitochondrial
    NP_001335096.1
    NP_001335097.1
    NP_694808.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348167.2 → NP_001335096.1  probable leucine--tRNA ligase, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125254, AC164123
      Consensus CDS
      CCDS23659.1
      UniProtKB/Swiss-Prot
      A6H6S4, Q8VDC0
      UniProtKB/TrEMBL
      Q14DP3, Q14DS6
      Conserved Domains (1) summary
      cl26128
      Location:56 → 900
      tRNA-synt_1g; tRNA synthetases class I (M)

    2. NM_001348168.2 → NP_001335097.1  probable leucine--tRNA ligase, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125254, AC164123
      UniProtKB/Swiss-Prot
      Q8VDC0
      Conserved Domains (1) summary
      cl26128
      Location:5 → 652
      tRNA-synt_1g; tRNA synthetases class I (M)

    3. NM_153168.4 → NP_694808.1  probable leucine--tRNA ligase, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_694808.1

      Status: VALIDATED

      Source sequence(s)
      AC125254, AC164123
      Consensus CDS
      CCDS23659.1
      UniProtKB/Swiss-Prot
      A6H6S4, Q8VDC0
      UniProtKB/TrEMBL
      Q14DP3, Q14DS6
      Related
      ENSMUSP00000036710.8, ENSMUST00000038863.9
      Conserved Domains (1) summary
      cl26128
      Location:56 → 900
      tRNA-synt_1g; tRNA synthetases class I (M)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      123196001..123291731
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VDC0.1 GenPept UniProtKB/Swiss-Prot:Q8VDC0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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