U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Mob2 MOB kinase activator 2 [ Mus musculus (house mouse) ]

    Gene ID: 101513, updated on 11-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Mob2provided by MGI
    Official Full Name
    MOB kinase activator 2provided by MGI
    Primary source
    MGI:MGI:1919891
    See related
    Ensembl:ENSMUSG00000025147 AllianceGenome:MGI:1919891
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mmh; 1110017M21Rik; 2700078K21Rik
    Summary
    Predicted to enable protein kinase activator activity. Acts upstream of or within actin cytoskeleton organization; positive regulation of neuron projection development; and positive regulation of protein phosphorylation. Located in cytoplasm and neuron projection terminus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and integumental system. Orthologous to human MOB2 (MOB kinase activator 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 13.7), colon adult (RPKM 11.4) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    7 F5; 7 87.5 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141562254..141614796, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (142008517..142061059, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20497 Neighboring gene predicted gene, 32539 Neighboring gene BR serine/threonine kinase 2 Neighboring gene microRNA 3104 Neighboring gene STARR-seq mESC enhancer starr_20498 Neighboring gene predicted gene, 25416 Neighboring gene dual specificity phosphatase 8 Neighboring gene predicted gene, 57785

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The promotion of neurite formation in Neuro2A cells by mouse Mob2 protein. Lin CH, et al. FEBS Lett, 2011 Feb 4. PMID 21237165
    2. JADE2 Is Essential for Hippocampal Synaptic Plasticity and Cognitive Functions in Mice. Fan M, et al. Biol Psychiatry, 2022 Nov 15. PMID 36008159
    3. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuron projection terminus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    MOB kinase activator 2
    Names
    Mps one binder kinase activator-like 2
    mob2 homolog
    ovary-specific MOB-like protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347560.1 → NP_001334489.1  MOB kinase activator 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL603836
      Consensus CDS
      CCDS85460.1
      UniProtKB/TrEMBL
      Q3TYF8
      Related
      ENSMUSP00000147608.2, ENSMUST00000211206.2
      Conserved Domains (1) summary
      pfam03637
      Location:5 → 115
      Mob1_phocein; Mob1/phocein family

    2. NM_001357705.1 → NP_001344634.1  MOB kinase activator 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate, frame-shifting splice site in the 3' coding region compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL603836
      Conserved Domains (1) summary
      pfam03637
      Location:32 → 140
      Mob1_phocein; Mob1/phocein family

    3. NM_001374635.1 → NP_001361564.1  MOB kinase activator 2 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (4).
      Source sequence(s)
      AL603836
      Consensus CDS
      CCDS90353.1
      UniProtKB/TrEMBL
      A0A1B0GR18
      Related
      ENSMUSP00000147340.2, ENSMUST00000209732.2
      Conserved Domains (1) summary
      pfam03637
      Location:63 → 231
      Mob1_phocein; Mob1/phocein family

    4. NM_001382351.1 → NP_001369280.1  MOB kinase activator 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL603836
      UniProtKB/TrEMBL
      Q3TYF8
      Related
      ENSMUSP00000147643.2, ENSMUST00000211000.2
      Conserved Domains (1) summary
      pfam03637
      Location:5 → 115
      Mob1_phocein; Mob1/phocein family

    5. NM_028308.2 → NP_082584.1  MOB kinase activator 2 isoform 1

      See identical proteins and their annotated locations for NP_082584.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the isoform 1.
      Source sequence(s)
      AL603836
      Consensus CDS
      CCDS40190.1
      UniProtKB/Swiss-Prot
      Q3UXL5, Q8VI63, Q9CZJ5
      Related
      ENSMUSP00000081455.3, ENSMUST00000084418.4
      Conserved Domains (1) summary
      pfam03637
      Location:32 → 200
      Mob1_phocein; Mob1/phocein family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      141562254..141614796 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152537.1 → XP_036008430.1  MOB kinase activator 2 isoform X1

      UniProtKB/TrEMBL
      A0A1B0GR18
      Conserved Domains (1) summary
      pfam03637
      Location:63 → 231
      Mob1_phocein; Mob1/phocein family

    2. XM_036152538.1 → XP_036008431.1  MOB kinase activator 2 isoform X3

      UniProtKB/TrEMBL
      Q3TYF8
      Conserved Domains (1) summary
      pfam03637
      Location:5 → 115
      Mob1_phocein; Mob1/phocein family

    3. XM_011241972.4 → XP_011240274.1  MOB kinase activator 2 isoform X2

      Conserved Domains (1) summary
      pfam03637
      Location:63 → 171
      Mob1_phocein; Mob1/phocein family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VI63.1 GenPept UniProtKB/Swiss-Prot:Q8VI63

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous