Brk1 BRICK1, SCAR/WAVE actin-nucleating complex subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Brk1provided by MGI
Official Full Name: BRICK1, SCAR/WAVE actin-nucleating complex subunitprovided by MGI
Primary source: MGI:MGI:1915406
See related: Ensembl:ENSMUSG00000033940 AllianceGenome:MGI:1915406
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 6720456B07Rik
Summary: Predicted to enable identical protein binding activity. Predicted to contribute to small GTPase binding activity. Acts upstream of or within several processes, including actin cytoskeleton organization; in utero embryonic development; and positive regulation of cell population proliferation. Located in lamellipodium. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; lung; and nervous system. Orthologous to human BRK1 (BRICK1 subunit of SCAR/WAVE actin nucleating complex). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in cortex adult (RPKM 93.6), frontal lobe adult (RPKM 90.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 E3; 6 52.81 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (113581733..113593912)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (113604772..113616951)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that genetic ablation of Brk1 results in dramatic defects in embryo compaction and development, suggesting an essential role for this protein in actin dynamics.
Title: Brick1 is an essential regulator of actin cytoskeleton required for embryonic development and cell transformation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH134621 (e-PCR)
- UniSTS:217900

AW011779 (e-PCR)
- UniSTS:165482

Brk1 (e-PCR), detects polymorphism
- UniSTS:547979

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
contributes_to small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament organization	IEA Inferred from Electronic Annotation more info
involved_in cell motility	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell motility	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin polymerization or depolymerization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of SCAR complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCAR complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein BRICK1

Names: probable protein BRICK1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.