Wdr91 WD repeat domain 91 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wdr91provided by MGI
Official Full Name: WD repeat domain 91provided by MGI
Primary source: MGI:MGI:2141558
See related: Ensembl:ENSMUSG00000058486 AllianceGenome:MGI:2141558
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 9530020G05Rik
Summary: Predicted to enable phosphatidylinositol 3-kinase regulator activity. Predicted to be involved in early endosome to late endosome transport; regulation of cellular protein catabolic process; and regulation of phosphatidylinositol 3-kinase activity. Predicted to be located in cytosol. Predicted to be active in early endosome membrane and late endosome membrane. Predicted to be extrinsic component of endosome membrane. Orthologous to human WDR91 (WD repeat domain 91). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in kidney adult (RPKM 7.5), thymus adult (RPKM 7.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B1; 6 15.19 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (34857361..34887766, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (34880426..34910831, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Rab7 effector WDR91 promotes autophagy-lysosome degradation in neurons by regulating lysosome fusion.
Title: The Rab7 effector WDR91 promotes autophagy-lysosome degradation in neurons by regulating lysosome fusion.
WDR91 serves as a Rab7 effector that is essential for neuronal development by facilitating endosome conversion in the endosome-lysosome pathway.
Title: WDR91 is a Rab7 effector required for neuronal development.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136243 (e-PCR)
- UniSTS:210237

AI987683 (e-PCR)
- UniSTS:165459

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatidylinositol 3-kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol 3-kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in early endosome to late endosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in early endosome to late endosome transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in early endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in late endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: WD repeat-containing protein 91

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013366.1 → NP_001013384.1 WD repeat-containing protein 91

See identical proteins and their annotated locations for NP_001013384.1

Status: PROVISIONAL

Source sequence(s)

BC055046

Consensus CDS

CCDS39457.1

UniProtKB/Swiss-Prot

Q7TMQ7, Q80XN1

Related

ENSMUSP00000079974.6, ENSMUST00000081214.12

Conserved Domains (3) summary

COG2319
Location:400 → 740

WD40; WD40 repeat [General function prediction only]

sd00039
Location:487 → 558

7WD40; WD40 repeat [structural motif]

cl02567
Location:408 → 740

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...