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    Snx21 sorting nexin family member 21 [ Mus musculus (house mouse) ]

    Gene ID: 101113, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Snx21provided by MGI
    Official Full Name
    sorting nexin family member 21provided by MGI
    Primary source
    MGI:MGI:1917729
    See related
    Ensembl:ENSMUSG00000050373 AllianceGenome:MGI:1917729
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5730407K14Rik
    Summary
    Enables phosphatidylinositol-3-phosphate binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in protein transport. Located in early endosome membrane. Is expressed in testis. Orthologous to human SNX21 (sorting nexin family member 21). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 51.8), ovary adult (RPKM 18.5) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 H3; 2 85.27 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164627535..164635730)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164785759..164793810)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2C Neighboring gene troponin C2, fast Neighboring gene acyl-CoA thioesterase 8 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164630130-164630494 Neighboring gene zinc finger SWIM-type containing 3 Neighboring gene STARR-seq mESC enhancer starr_06336 Neighboring gene zinc finger SWIM-type containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structure and Membrane Binding Properties of the Endosomal Tetratricopeptide Repeat (TPR) Domain-containing Sorting Nexins SNX20 and SNX21. Clairfeuille T, et al. J Biol Chem, 2015 Jun 5. PMID 25882846, Free PMC Article
    2. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538
    3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin-21

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399716.1 → NP_001386645.1  sorting nexin-21 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL591127
      UniProtKB/TrEMBL
      Q149Q9

    2. NM_133924.4 → NP_598685.2  sorting nexin-21 isoform 1

      See identical proteins and their annotated locations for NP_598685.2

      Status: VALIDATED

      Source sequence(s)
      AL591127
      Consensus CDS
      CCDS38328.1
      UniProtKB/Swiss-Prot
      Q3UR97
      Related
      ENSMUSP00000054137.7, ENSMUST00000056181.7
      Conserved Domains (3) summary
      sd00006
      Location:234 → 258
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:237 → 302
      TPR_12; Tetratricopeptide repeat
      cl02563
      Location:121 → 232
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      164627535..164635730
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246444.2 → XP_030102304.1  sorting nexin-21 isoform X1

      Conserved Domains (3) summary
      sd00006
      Location:243 → 267
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:243 → 312
      TPR_12; Tetratricopeptide repeat
      cl02563
      Location:121 → 241
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    2. XM_006498528.5 → XP_006498591.1  sorting nexin-21 isoform X2

      Conserved Domains (3) summary
      sd00006
      Location:237 → 261
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:237 → 306
      TPR_12; Tetratricopeptide repeat
      cl02563
      Location:121 → 235
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    3. XM_006498530.5 → XP_006498593.1  sorting nexin-21 isoform X4

      See identical proteins and their annotated locations for XP_006498593.1

      UniProtKB/TrEMBL
      Q149Q9
      Conserved Domains (2) summary
      pfam13424
      Location:89 → 158
      TPR_12; Tetratricopeptide repeat
      cl02563
      Location:1 → 87
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    4. XM_006498529.5 → XP_006498592.1  sorting nexin-21 isoform X3

      Conserved Domains (2) summary
      pfam13424
      Location:107 → 176
      TPR_12; Tetratricopeptide repeat
      cl02563
      Location:7 → 105
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    5. XM_006498533.5 → XP_006498596.1  sorting nexin-21 isoform X4

      See identical proteins and their annotated locations for XP_006498596.1

      UniProtKB/TrEMBL
      Q149Q9
      Conserved Domains (2) summary
      pfam13424
      Location:89 → 158
      TPR_12; Tetratricopeptide repeat
      cl02563
      Location:1 → 87
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    6. XM_030246455.1 → XP_030102315.1  sorting nexin-21 isoform X4

      UniProtKB/TrEMBL
      Q149Q9
      Conserved Domains (2) summary
      pfam13424
      Location:89 → 158
      TPR_12; Tetratricopeptide repeat
      cl02563
      Location:1 → 87
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    7. XM_006498532.2 → XP_006498595.1  sorting nexin-21 isoform X4

      See identical proteins and their annotated locations for XP_006498595.1

      UniProtKB/TrEMBL
      Q149Q9
      Conserved Domains (2) summary
      pfam13424
      Location:89 → 158
      TPR_12; Tetratricopeptide repeat
      cl02563
      Location:1 → 87
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    RNA

    1. XR_003949535.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UR97.1 GenPept UniProtKB/Swiss-Prot:Q3UR97

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