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    Ttll3 tubulin tyrosine ligase-like family, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 101100, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ttll3provided by MGI
    Official Full Name
    tubulin tyrosine ligase-like family, member 3provided by MGI
    Primary source
    MGI:MGI:2141418
    See related
    Ensembl:ENSMUSG00000030276 AllianceGenome:MGI:2141418
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4833441J24Rik
    Summary
    Enables protein-glycine ligase activity, initiating. Involved in flagellated sperm motility and protein polyglycylation. Acts upstream of or within cilium assembly. Located in axoneme; microtubule cytoskeleton; and sperm flagellum. Is expressed in midbrain ventricular layer and pons ventricular layer. Orthologous to human TTLL3 (tubulin tyrosine ligase like 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 32.1), thymus adult (RPKM 12.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 E3; 6 52.76 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (113366221..113391553)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (113389260..113414592)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene chaperonin containing Tcp1, subunit 3 (gamma) pseudogene Neighboring gene transcriptional adaptor 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:113327864-113328099 Neighboring gene actin related protein 2/3 complex, subunit 4 Neighboring gene STARR-positive B cell enhancer ABC_E1706 Neighboring gene RNA pseudouridylate synthase domain containing 3 Neighboring gene cell death-inducing DFFA-like effector c Neighboring gene predicted gene, 52871

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility. Gadadhar S, et al. Science, 2021 Jan 8. PMID 33414192, Free PMC Article
    2. Alterations in the balance of tubulin glycylation and glutamylation in photoreceptors leads to retinal degeneration. Bosch Grau M, et al. J Cell Sci, 2017 Mar 1. PMID 28104815
    3. Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon. Rocha C, et al. EMBO J, 2014 Oct 1. PMID 25180231, Free PMC Article
    4. Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia. Bosch Grau M, et al. J Cell Biol, 2013 Aug 5. PMID 23897886, Free PMC Article
    5. Asialoglycoprotein Receptor 1 Functions as a Tumor Suppressor in Liver Cancer via Inhibition of STAT3. Zhu X, et al. Cancer Res, 2022 Nov 2. PMID 36043912

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility.
      Title: Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility.
    2. Decreased levels of TTLL3 expression are linked to the development of colorectal carcinomas.
      Title: Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon.
    3. The TTLL3 was required for stability and maintenance of ependymal cilia, whereas the polyglutamylase TTLL6 was necessary for coordinated beating behavior.
      Title: Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (7)  1 citation
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-glycine ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-glycine ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-glycine ligase activity, initiating IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-glycine ligase activity, initiating IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-glycine ligase activity, initiating IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cilium assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cilium movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein polyglycylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein polyglycylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axoneme IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tubulin monoglycylase TTLL3
    Names
    TTL domain protein
    tubulin--tyrosine ligase-like protein 3
    NP_001136204.1
    NP_598684.4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142732.1 → NP_001136204.1  tubulin monoglycylase TTLL3 isoform 2

      See identical proteins and their annotated locations for NP_001136204.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant has an alternate 5' exon and lacks multiple 3' exons but has an alternate 3' end sequence, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus and a shorter and different C-terminus, as compared to isoform 1.
      Source sequence(s)
      AK029462, AM690746, CF916454
      Consensus CDS
      CCDS85118.1
      UniProtKB/Swiss-Prot
      A4Q9E5
      Related
      ENSMUSP00000145049.2, ENSMUST00000204026.3

    2. NM_133923.7 → NP_598684.4  tubulin monoglycylase TTLL3 isoform 1

      See identical proteins and their annotated locations for NP_598684.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AA285487, AC153910, AK080321, AM690746
      Consensus CDS
      CCDS39593.2
      UniProtKB/Swiss-Prot
      A4Q9E5, Q8BV51, Q8C0Y7, Q8VDS2
      UniProtKB/TrEMBL
      H7BX03
      Related
      ENSMUSP00000032414.5, ENSMUST00000032414.11
      Conserved Domains (1) summary
      pfam03133
      Location:423 → 698
      TTL; Tubulin-tyrosine ligase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      113366221..113391553
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4Q9E5.1 GenPept UniProtKB/Swiss-Prot:A4Q9E5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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