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    Smpd5 sphingomyelin phosphodiesterase 5 [ Mus musculus (house mouse) ]

    Gene ID: 100503915, updated on 8-Mar-2024

    Summary

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    Official Symbol
    Smpd5provided by MGI
    Official Full Name
    sphingomyelin phosphodiesterase 5provided by MGI
    Primary source
    MGI:MGI:3709877
    See related
    Ensembl:ENSMUSG00000071724 AllianceGenome:MGI:3709877
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm10345; MA-nSMase
    Summary
    Enables sphingomyelin phosphodiesterase activity. Involved in ceramide biosynthetic process and sphingomyelin catabolic process. Acts upstream of or within ceramide metabolic process. Located in endoplasmic reticulum membrane and mitochondrial membrane. Orthologous to human SMPD5 (sphingomyelin phosphodiesterase 5 (pseudogene)). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 60.2) and spleen adult (RPKM 3.1) See more
    Orthologs
    all
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    Genomic context

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    Location:
    15 D3; 15 35.67 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76178478..76181096)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76294278..76296896)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene spermatogenesis and centriole associated 1 Neighboring gene myocardial infraction associated transcript 2 Neighboring gene microRNA 3079 Neighboring gene 5-oxoprolinase (ATP-hydrolysing) Neighboring gene STARR-seq mESC enhancer starr_39050 Neighboring gene STARR-positive B cell enhancer ABC_E7384 Neighboring gene exosome component 4 Neighboring gene GPI anchor attachment protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A tissue-specific atlas of mouse protein phosphorylation and expression. Huttlin EL, et al. Cell, 2010 Dec 23. PMID 21183079, Free PMC Article
    2. Identification and characterization of murine mitochondria-associated neutral sphingomyelinase (MA-nSMase), the mammalian sphingomyelin phosphodiesterase 5. Wu BX, et al. J Biol Chem, 2010 Jun 4. PMID 20378533, Free PMC Article
    3. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cloned and characterized a mitochondria-associated nSMase (MA-nSMase) that displays significant homology to nSMase2 and possesses the same catalytic core residues as members of the N-SMase family
      Title: Identification and characterization of murine mitochondria-associated neutral sphingomyelinase (MA-nSMase), the mammalian sphingomyelin phosphodiesterase 5.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sphingomyelin phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sphingomyelin phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within ceramide metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingomyelin catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sphingomyelin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sphingomyelin phosphodiesterase 5
    Names
    mitochondria-associated nSMase
    mitochondrial neutral sphingomyelinase
    mtnSMase
    NP_001182466.1
    XP_006520290.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195537.2 → NP_001182466.1  sphingomyelin phosphodiesterase 5

      See identical proteins and their annotated locations for NP_001182466.1

      Status: VALIDATED

      Source sequence(s)
      AC155074
      Consensus CDS
      CCDS56988.1
      UniProtKB/Swiss-Prot
      D6MZJ6
      Related
      ENSMUSP00000134687.2, ENSMUST00000163991.4
      Conserved Domains (1) summary
      cd09078
      Location:201 → 474
      nSMase; Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      76178478..76181096
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520227.2 → XP_006520290.1  sphingomyelin phosphodiesterase 5 isoform X1

      Conserved Domains (1) summary
      cd09078
      Location:201 → 389
      nSMase; Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine

    RNA

    1. XR_003951337.1 RNA Sequence

    2. XR_383962.4 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_028579.1: Suppressed sequence

      Description
      NG_028579.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D6MZJ6.1 GenPept UniProtKB/Swiss-Prot:D6MZJ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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