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    Mob3c MOB kinase activator 3C [ Mus musculus (house mouse) ]

    Gene ID: 100465, updated on 5-Mar-2024

    Summary

    Official Symbol
    Mob3cprovided by MGI
    Official Full Name
    MOB kinase activator 3Cprovided by MGI
    Primary source
    MGI:MGI:2140623
    See related
    Ensembl:ENSMUSG00000028709 AllianceGenome:MGI:2140623
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mobkl2c; D130076I06Rik
    Summary
    Predicted to enable protein kinase activator activity. Predicted to be involved in positive regulation of protein phosphorylation and signal transduction. Predicted to be active in cytoplasm and nucleus. Orthologous to human MOB3C (MOB kinase activator 3C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 5.9), small intestine adult (RPKM 5.4) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    4 D1; 4 53.06 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (115675962..115693382)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (115827886..115836185)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene EF-hand calcium binding domain 14 Neighboring gene testis expressed 38 Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 1 Neighboring gene STARR-seq mESC enhancer starr_11125 Neighboring gene STARR-positive B cell enhancer ABC_E1650 Neighboring gene MAP kinase-interacting serine/threonine kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E6199 Neighboring gene kinocilin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    MOB kinase activator 3C
    Names
    MOB1, Mps One Binder kinase activator-like 2C
    mob1 homolog 2C

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175308.5NP_780517.1  MOB kinase activator 3C

      See identical proteins and their annotated locations for NP_780517.1

      Status: VALIDATED

      Source sequence(s)
      AL626806, AL627085
      Consensus CDS
      CCDS18497.1
      UniProtKB/Swiss-Prot
      Q3UFI6, Q8BJG4
      UniProtKB/TrEMBL
      B1ASD4
      Related
      ENSMUSP00000030477.4, ENSMUST00000030477.4
      Conserved Domains (1) summary
      pfam03637
      Location:35207
      Mob1_phocein; Mob1/phocein family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      115675962..115693382
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240381.2XP_011238683.1  MOB kinase activator 3C isoform X1

      See identical proteins and their annotated locations for XP_011238683.1

      UniProtKB/Swiss-Prot
      Q3UFI6, Q8BJG4
      UniProtKB/TrEMBL
      B1ASD4
      Conserved Domains (1) summary
      pfam03637
      Location:35207
      Mob1_phocein; Mob1/phocein family
    2. XM_011240382.3XP_011238684.1  MOB kinase activator 3C isoform X1

      See identical proteins and their annotated locations for XP_011238684.1

      UniProtKB/Swiss-Prot
      Q3UFI6, Q8BJG4
      UniProtKB/TrEMBL
      B1ASD4
      Conserved Domains (1) summary
      pfam03637
      Location:35207
      Mob1_phocein; Mob1/phocein family
    3. XM_036163554.1XP_036019447.1  MOB kinase activator 3C isoform X1

      UniProtKB/Swiss-Prot
      Q3UFI6, Q8BJG4
      UniProtKB/TrEMBL
      B1ASD4
      Conserved Domains (1) summary
      pfam03637
      Location:35207
      Mob1_phocein; Mob1/phocein family

    RNA

    1. XR_004941793.1 RNA Sequence