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    Adh6b alcohol dehydrogenase 6B (class V) [ Mus musculus (house mouse) ]

    Gene ID: 100417514, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Adh6bprovided by MGI
    Official Full Name
    alcohol dehydrogenase 6B (class V)provided by MGI
    Primary source
    MGI:MGI:2446626
    See related
    Ensembl:ENSMUSG00000074206 AllianceGenome:MGI:2446626
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adh5b
    Summary
    Predicted to enable NAD-retinol dehydrogenase activity; alcohol dehydrogenase activity, zinc-dependent; and zinc ion binding activity. Predicted to be involved in ethanol oxidation; response to ethanol; and retinoid metabolic process. Predicted to be active in cytosol. Orthologous to human ADH6 (alcohol dehydrogenase 6 (class V)). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Adh6b in Genome Data Viewer
    Location:
    3 G3; 3 64.21 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (138047176..138064621)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (138341412..138358859)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene 16559 Neighboring gene alcohol dehydrogenase 6A (class V) Neighboring gene predicted gene, 23467 Neighboring gene alcohol dehydrogenase 6 (class V), pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_09107 Neighboring gene alcohol dehydrogenase 4 (class II), pi polypeptide

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tissue expression pattern of class II and class V genes found in the Adh complex on mouse chromosome 3. Szalai G, et al. Biochem Genet, 2008 Dec. PMID 18802746
    2. Merging protein, gene and genomic data: the evolution of the MDR-ADH family. Gonzàlez-Duarte R, et al. Heredity (Edinb), 2005 Sep. PMID 16121213
    3. Organization of six functional mouse alcohol dehydrogenase genes on two overlapping bacterial artificial chromosomes. Szalai G, et al. Eur J Biochem, 2002 Jan. PMID 11784316
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Adh6b gene expression patterns.
      Title: Tissue expression pattern of class II and class V genes found in the Adh complex on mouse chromosome 3.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alcohol dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alcohol dehydrogenase (NAD+) activity, zinc-dependent IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables all-trans-retinol dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to ethanol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retinoic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retinol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    alcohol dehydrogenase 6B (class V)
    NP_001357786.1
    NP_001398420.1
    NP_001398421.1
    NP_001398422.1
    XP_030108194.1
    XP_036018689.1
    XP_036018690.1
    XP_036018691.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370857.2 → NP_001357786.1  alcohol dehydrogenase 6B (class V)

      Status: VALIDATED

      Source sequence(s)
      AC079845
      Consensus CDS
      CCDS89693.1
      UniProtKB/TrEMBL
      A0A1D5RMB0
      Related
      ENSMUSP00000148703.2, ENSMUST00000199673.6
      Conserved Domains (1) summary
      cl16912
      Location:10 → 382
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

    2. NM_001411491.1 → NP_001398420.1  alcohol dehydrogenase 6B (class V)

      Status: VALIDATED

      Source sequence(s)
      AC079845
      UniProtKB/TrEMBL
      A0A1D5RMB0

    3. NM_001411492.1 → NP_001398421.1  alcohol dehydrogenase 6B (class V)

      Status: VALIDATED

      Source sequence(s)
      AC079845
      UniProtKB/TrEMBL
      A0A1D5RMB0

    4. NM_001411493.1 → NP_001398422.1  alcohol dehydrogenase 6B (class V)

      Status: VALIDATED

      Source sequence(s)
      AC079845
      UniProtKB/TrEMBL
      A0A1D5RMB0

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      138047176..138064621
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162796.1 → XP_036018689.1  alcohol dehydrogenase 6B (class V) isoform X1

      UniProtKB/TrEMBL
      A0A1D5RMB0
      Conserved Domains (1) summary
      cl16912
      Location:10 → 382
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

    2. XM_036162797.1 → XP_036018690.1  alcohol dehydrogenase 6B (class V) isoform X1

      UniProtKB/TrEMBL
      A0A1D5RMB0
      Conserved Domains (1) summary
      cl16912
      Location:10 → 382
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

    3. XM_036162798.1 → XP_036018691.1  alcohol dehydrogenase 6B (class V) isoform X2

      Conserved Domains (1) summary
      cl16912
      Location:30 → 364
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

    4. XM_030252334.2 → XP_030108194.1  alcohol dehydrogenase 6B (class V) isoform X3

      Conserved Domains (1) summary
      cl16912
      Location:1 → 318
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_017403.2: Suppressed sequence

      Description
      NG_017403.2: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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