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    Gpn2 GPN-loop GTPase 2 [ Mus musculus (house mouse) ]

    Gene ID: 100210, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Gpn2provided by MGI
    Official Full Name
    GPN-loop GTPase 2provided by MGI
    Primary source
    MGI:MGI:2140368
    See related
    Ensembl:ENSMUSG00000028848 AllianceGenome:MGI:2140368
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Atpbd1b
    Summary
    Predicted to enable GTPase activity. Is expressed in collecting duct; liver; renal calyx; and ureter. Orthologous to human GPN2 (GPN-loop GTPase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 24.7), duodenum adult (RPKM 20.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D2.3; 4 66.25 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (133311684..133319046)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (133584373..133591735)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene nuclear receptor subfamily 0, group B, member 2 Neighboring gene G patch domain containing 3 Neighboring gene predicted gene, 42324 Neighboring gene STARR-seq mESC enhancer starr_11639 Neighboring gene stratifin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article
    2. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
    3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GPN-loop GTPase 2
    Names
    ATP binding domain 1 family, member B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290742.1 → NP_001277671.1  GPN-loop GTPase 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AL627228
      Consensus CDS
      CCDS71484.1
      UniProtKB/TrEMBL
      A2A9F7
      Related
      ENSMUSP00000101519.2, ENSMUST00000105899.2
      Conserved Domains (2) summary
      COG1100
      Location:13 → 159
      Gem1; GTPase SAR1 family domain [General function prediction only]
      pfam03029
      Location:14 → 238
      ATP_bind_1; Conserved hypothetical ATP binding protein

    2. NM_133884.2 → NP_598645.2  GPN-loop GTPase 2 isoform 1

      See identical proteins and their annotated locations for NP_598645.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BQ552936, CN721622, CO798620
      Consensus CDS
      CCDS18753.1
      UniProtKB/Swiss-Prot
      A2A9E9, Q8VEJ1
      Related
      ENSMUSP00000030661.8, ENSMUST00000030661.14
      Conserved Domains (2) summary
      COG1100
      Location:13 → 182
      Gem1; GTPase SAR1 family domain [General function prediction only]
      pfam03029
      Location:14 → 261
      ATP_bind_1; Conserved hypothetical ATP binding protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      133311684..133319046
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VEJ1.2 GenPept UniProtKB/Swiss-Prot:Q8VEJ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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