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    Zmym6 zinc finger, MYM-type 6 [ Mus musculus (house mouse) ]

    Gene ID: 100177, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zmym6provided by MGI
    Official Full Name
    zinc finger, MYM-type 6provided by MGI
    Primary source
    MGI:MGI:106505
    See related
    Ensembl:ENSMUSG00000042408 AllianceGenome:MGI:106505
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp258; D4Wsu24e; 9330177P20Rik
    Summary
    Predicted to be involved in cytoskeleton organization and regulation of cell morphogenesis. Is expressed in extraembryonic component. Orthologous to human ZMYM6 (zinc finger MYM-type containing 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 13.5), CNS E14 (RPKM 11.4) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D2.2; 4 61.25 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (126971176..127018167)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (127077383..127124374)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11418 Neighboring gene splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) Neighboring gene zinc finger, MYM domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E9012 Neighboring gene STARR-seq mESC enhancer starr_11419 Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene STARR-seq mESC enhancer starr_11420 Neighboring gene predicted gene, 25600 Neighboring gene STARR-seq mESC enhancer starr_11421 Neighboring gene transmembrane protein 35B Neighboring gene STARR-seq mESC enhancer starr_11422 Neighboring gene 40S ribosomal protein S28 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord. Yoshida Y, et al. Neuron, 2006 Dec 7. PMID 17145500, Free PMC Article
    2. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, et al. Hum Mol Genet, 1998 Nov. PMID 9811942
    3. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger MYM-type protein 6
    Names
    likely ortholog of H. sapiens zinc finger protein 258 (ZNF258)
    probably fused to an N terminal zinc finger domain
    transposase-like protein
    zinc finger protein 258

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285885.1 → NP_001272814.1  zinc finger MYM-type protein 6 isoform a

      See identical proteins and their annotated locations for NP_001272814.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 2 encode isoform a.
      Source sequence(s)
      AK035136, BC094598
      Consensus CDS
      CCDS18664.1
      UniProtKB/TrEMBL
      B2RU44, Q8BS54
      Conserved Domains (1) summary
      pfam06467
      Location:116 → 159
      zf-FCS; MYM-type Zinc finger with FCS sequence motif

    2. NM_001285887.1 → NP_001272816.1  zinc finger MYM-type protein 6 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AK035136, AK081836, BC094598
      Consensus CDS
      CCDS71469.1
      UniProtKB/TrEMBL
      A2A7U2, B2RU44
      Related
      ENSMUSP00000092303.4, ENSMUST00000094713.4
      Conserved Domains (1) summary
      pfam06467
      Location:116 → 159
      zf-FCS; MYM-type Zinc finger with FCS sequence motif

    3. NM_001285888.1 → NP_001272817.1  zinc finger MYM-type protein 6 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has alternate 5' exon structure and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AK035136, AL606985, BC094598
      UniProtKB/TrEMBL
      Q8K048
      Conserved Domains (1) summary
      pfam06467
      Location:14 → 57
      zf-FCS; MYM-type Zinc finger with FCS sequence motif

    4. NM_177462.5 → NP_803413.1  zinc finger MYM-type protein 6 isoform a

      See identical proteins and their annotated locations for NP_803413.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode isoform a.
      Source sequence(s)
      AK035136, BC094598
      Consensus CDS
      CCDS18664.1
      UniProtKB/TrEMBL
      B2RU44, Q8BS54
      Related
      ENSMUSP00000045366.7, ENSMUST00000046751.13
      Conserved Domains (1) summary
      pfam06467
      Location:116 → 159
      zf-FCS; MYM-type Zinc finger with FCS sequence motif

    RNA

    1. NR_104366.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) includes an additional exon in the 5' region, uses an alternate splice site in the central region, and lacks a segment in the 3' region, compared to variant 1. This variant is represented as non-coding because use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK035136, AL606985, BC094598

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      126971176..127018167
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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