Adat3 adenosine deaminase, tRNA-specific 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adat3provided by MGI
Official Full Name: adenosine deaminase, tRNA-specific 3provided by MGI
Primary source: MGI:MGI:1924344
See related: Ensembl:ENSMUSG00000113640 AllianceGenome:MGI:1924344
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A430024H01Rik
Summary: Predicted to contribute to tRNA-specific adenosine-34 deaminase activity. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human ADAT3 (adenosine deaminase tRNA specific 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 16.7), testis adult (RPKM 16.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (80438714..80443488)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (80602880..80607654)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The structure of the mouse ADAT2/ADAT3 complex reveals the molecular basis for mammalian tRNA wobble adenosine-to-inosine deamination.
Title: The structure of the mouse ADAT2/ADAT3 complex reveals the molecular basis for mammalian tRNA wobble adenosine-to-inosine deamination.

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General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to tRNA-specific adenosine-34 deaminase activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: probable inactive tRNA-specific adenosine deaminase-like protein 3

Names: adenosine deaminase, tRNA-specific 3, TAD2 homolog; tRNA-specific adenosine deaminase 3; tRNA-specific adenosine deaminase-like protein 3; tRNA-specific adenosine-34 deaminase subunit ADAT3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100606.1 → NP_001094076.1 probable inactive tRNA-specific adenosine deaminase-like protein 3

See identical proteins and their annotated locations for NP_001094076.1

Status: VALIDATED

Source sequence(s)

AK020747, BX632866, BY036102

Consensus CDS

CCDS48637.1

UniProtKB/Swiss-Prot

Q6PAT0

Related

ENSMUSP00000040551.5, ENSMUST00000038411.5

Conserved Domains (1) summary

COG0590
Location:195 → 345

TadA; tRNA(Arg) A34 adenosine deaminase TadA [Translation, ribosomal structure and biogenesis]