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    Ddx43 DEAD box helicase 43 [ Mus musculus (house mouse) ]

    Gene ID: 100048658, updated on 21-Apr-2024

    Summary

    Official Symbol
    Ddx43provided by MGI
    Official Full Name
    DEAD box helicase 43provided by MGI
    Primary source
    MGI:MGI:3642857
    See related
    Ensembl:ENSMUSG00000070291 AllianceGenome:MGI:3642857
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable RNA binding activity and RNA helicase activity. Orthologous to human DDX43 (DEAD-box helicase 43). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 3.0), limb E14.5 (RPKM 0.4) and 6 other tissues See more
    Orthologs
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    Genomic context

    Location:
    9 E1; 9 43.65 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (78303059..78330871)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (78395777..78423589)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene oocyte expressed protein Neighboring gene 60S ribosomal protein L9-like Neighboring gene STARR-positive B cell enhancer mm9_chr9:78278373-78278674 Neighboring gene predicted gene 8093 Neighboring gene cyclic GMP-AMP synthase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (2) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    probable ATP-dependent RNA helicase DDX43
    Names
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
    NP_001177973.1
    XP_006510797.1
    XP_006510798.1
    XP_036010385.1
    XP_036010386.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191044.1NP_001177973.1  probable ATP-dependent RNA helicase DDX43

      Status: PROVISIONAL

      Source sequence(s)
      AC138587, AC158987
      Consensus CDS
      CCDS52870.1
      UniProtKB/TrEMBL
      D3Z6P9
      Related
      ENSMUSP00000108994.2, ENSMUST00000113367.2
      Conserved Domains (4) summary
      smart00487
      Location:255453
      DEXDc; DEAD-like helicases superfamily
      cd00079
      Location:461588
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00105
      Location:73127
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd00268
      Location:249446
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      78303059..78330871
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154492.1XP_036010385.1  probable ATP-dependent RNA helicase DDX43 isoform X1

      Conserved Domains (2) summary
      PTZ00110
      Location:169580
      PTZ00110; helicase; Provisional
      cd22430
      Location:68133
      KH-I_DDX43_DDX53; type I K homology (KH) RNA-binding domain found in DEAD box protein 43 (DDX43), DEAD box protein 53 (DDX53) and similar proteins
    2. XM_006510735.5XP_006510798.1  probable ATP-dependent RNA helicase DDX43 isoform X4

      Conserved Domains (2) summary
      pfam00013
      Location:73129
      KH_1; KH domain
      cl28899
      Location:251343
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    3. XM_036154493.1XP_036010386.1  probable ATP-dependent RNA helicase DDX43 isoform X2

      Conserved Domains (1) summary
      PTZ00110
      Location:23435
      PTZ00110; helicase; Provisional
    4. XM_006510734.1XP_006510797.1  probable ATP-dependent RNA helicase DDX43 isoform X3

      Conserved Domains (1) summary
      PTZ00110
      Location:1347
      PTZ00110; helicase; Provisional

    RNA

    1. XR_379393.2 RNA Sequence

    2. XR_004935286.1 RNA Sequence