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    Zfp850 zinc finger protein 850 [ Mus musculus (house mouse) ]

    Gene ID: 100043772, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Zfp850provided by MGI
    Official Full Name
    zinc finger protein 850provided by MGI
    Primary source
    MGI:MGI:3036281
    See related
    Ensembl:ENSMUSG00000096916 AllianceGenome:MGI:3036281
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm4636; C130069I09Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF780A (zinc finger protein 780A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Zfp850 in Genome Data Viewer
    Location:
    7 A3; 7 15.97 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (27683896..27713634, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27984471..28014210, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 780B Neighboring gene STARR-positive B cell enhancer ABC_E2231 Neighboring gene vomeronasal 1 receptor, pseudogene 87 Neighboring gene STARR-positive B cell enhancer ABC_E1084 Neighboring gene STARR-seq mESC enhancer starr_18400 Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase, 4 Neighboring gene Fc fragment of IgG binding protein Neighboring gene tectorin alpha pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article
    2. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
    3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC35631

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 850

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001254951.1 → NP_001241880.1  zinc finger protein 850

      See identical proteins and their annotated locations for NP_001241880.1

      Status: VALIDATED

      Source sequence(s)
      AC139063, AC158220, BU925220, CF735501
      Consensus CDS
      CCDS57531.1
      UniProtKB/TrEMBL
      A0A087WSI7, J3QPC5
      Related
      ENSMUSP00000141063.3, ENSMUST00000180502.8
      Conserved Domains (4) summary
      smart00349
      Location:14 → 75
      KRAB; krueppel associated box
      COG5048
      Location:279 → 671
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:202 → 222
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:256 → 278
      zf-C2H2; Zinc finger, C2H2 type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      27683896..27713634 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250406.4 → XP_011248708.1  zinc finger protein 850 isoform X1

      See identical proteins and their annotated locations for XP_011248708.1

      UniProtKB/TrEMBL
      A0A087WSI7, J3QPC5
      Related
      ENSMUSP00000137192.2, ENSMUST00000180024.2
      Conserved Domains (4) summary
      smart00349
      Location:14 → 75
      KRAB; krueppel associated box
      COG5048
      Location:279 → 671
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:202 → 222
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:256 → 278
      zf-C2H2; Zinc finger, C2H2 type

    2. XM_011250405.4 → XP_011248707.1  zinc finger protein 850 isoform X1

      See identical proteins and their annotated locations for XP_011248707.1

      UniProtKB/TrEMBL
      A0A087WSI7, J3QPC5
      Conserved Domains (4) summary
      smart00349
      Location:14 → 75
      KRAB; krueppel associated box
      COG5048
      Location:279 → 671
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:202 → 222
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:256 → 278
      zf-C2H2; Zinc finger, C2H2 type

    3. XM_011250404.4 → XP_011248706.1  zinc finger protein 850 isoform X1

      See identical proteins and their annotated locations for XP_011248706.1

      UniProtKB/TrEMBL
      A0A087WSI7, J3QPC5
      Conserved Domains (4) summary
      smart00349
      Location:14 → 75
      KRAB; krueppel associated box
      COG5048
      Location:279 → 671
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:202 → 222
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:256 → 278
      zf-C2H2; Zinc finger, C2H2 type

    4. XM_036152497.1 → XP_036008390.1  zinc finger protein 850 isoform X2

      Conserved Domains (4) summary
      COG5048
      Location:244 → 636
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:167 → 187
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:221 → 243
      zf-C2H2; Zinc finger, C2H2 type
      cl02581
      Location:18 → 40
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    5. XM_030241930.2 → XP_030097790.1  zinc finger protein 850 isoform X2

      Conserved Domains (4) summary
      COG5048
      Location:244 → 636
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:167 → 187
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:221 → 243
      zf-C2H2; Zinc finger, C2H2 type
      cl02581
      Location:18 → 40
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    6. XM_036152496.1 → XP_036008389.1  zinc finger protein 850 isoform X2

      Conserved Domains (4) summary
      COG5048
      Location:244 → 636
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:167 → 187
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:221 → 243
      zf-C2H2; Zinc finger, C2H2 type
      cl02581
      Location:18 → 40
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001100456.1: Suppressed sequence

      Description
      NM_001100456.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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