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    Morrbid myeloid RNA regulator of BCL2L11 induced cell death [ Mus musculus (house mouse) ]

    Gene ID: 100043424, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Morrbidprovided by MGI
    Official Full Name
    myeloid RNA regulator of BCL2L11 induced cell deathprovided by MGI
    Primary source
    MGI:MGI:3652191
    See related
    Ensembl:ENSMUSG00000074813 AllianceGenome:MGI:3652191
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cytor; Gm14005; Mir4435-2hg
    Summary
    Orthologous to human MIR4435-2HG (MIR4435-2 host gene). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    Location:
    2 F1; 2 62.31 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (128140583..128271271, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (128298663..128429351, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene acyl-Coenzyme A oxidase-like Neighboring gene STARR-positive B cell enhancer mm9_chr2:127953069-127953369 Neighboring gene STARR-seq mESC enhancer starr_05636 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:127978569-127978830 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:127981992-127982193 Neighboring gene BCL2 like 11 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:128029897-128030080 Neighboring gene predicted gene 14009 Neighboring gene STARR-seq mESC enhancer starr_05639 Neighboring gene STARR-seq mESC enhancer starr_05640 Neighboring gene STARR-seq mESC enhancer starr_05641 Neighboring gene STARR-positive B cell enhancer ABC_E5979 Neighboring gene STARR-seq mESC enhancer starr_05642 Neighboring gene STARR-positive B cell enhancer ABC_E7860 Neighboring gene STARR-positive B cell enhancer ABC_E11707 Neighboring gene STARR-positive B cell enhancer ABC_E10142 Neighboring gene STARR-positive B cell enhancer ABC_E11160 Neighboring gene STARR-positive B cell enhancer mm9_chr2:128221938-128222238 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:128238239-128238556 Neighboring gene predicted gene 14010 Neighboring gene predicted gene, 36154 Neighboring gene predicted gene 29010 Neighboring gene predicted gene, 39928 Neighboring gene predicted gene, 39927

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The exercise-induced long noncoding RNA CYTOR promotes fast-twitch myogenesis in aging. Wohlwend M, et al. Sci Transl Med, 2021 Dec 8. PMID 34878822
    2. Role of lncRNA Morrbid in PTPN11(Shp2)E76K-driven juvenile myelomonocytic leukemia. Cai Z, et al. Blood Adv, 2020 Jul 28. PMID 32697817, Free PMC Article
    3. The long noncoding RNA Morrbid regulates CD8 T cells in response to viral infection. Kotzin JJ, et al. Proc Natl Acad Sci U S A, 2019 Jun 11. PMID 31138702, Free PMC Article
    4. Hyperglycemia cooperates with Tet2 heterozygosity to induce leukemia driven by proinflammatory cytokine-induced lncRNA Morrbid. Cai Z, et al. J Clin Invest, 2021 Jan 4. PMID 33090974, Free PMC Article
    5. The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan. Kotzin JJ, et al. Nature, 2016 Sep 8. PMID 27525555, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA MIR4435-2HG suppression regulates macrophage M1/M2 polarization and reduces intestinal inflammation in mice with ulcerative colitis.
      Title: LncRNA MIR4435-2HG suppression regulates macrophage M1/M2 polarization and reduces intestinal inflammation in mice with ulcerative colitis.
    2. Long non-coding RNA MIR4435-2HG/microRNA-125a-5p axis is involved in myocardial ischemic injuries.
      Title: Long non-coding RNA MIR4435-2HG/microRNA-125a-5p axis is involved in myocardial ischemic injuries.
    3. Hyperglycemia cooperates with Tet2 heterozygosity to induce leukemia driven by proinflammatory cytokine-induced lncRNA Morrbid.
      Title: Hyperglycemia cooperates with Tet2 heterozygosity to induce leukemia driven by proinflammatory cytokine-induced lncRNA Morrbid.
    4. Role of lncRNA Morrbid in PTPN11(Shp2)E76K-driven juvenile myelomonocytic leukemia.
      Title: Role of lncRNA Morrbid in PTPN11(Shp2)E76K-driven juvenile myelomonocytic leukemia.
    5. Targeting Bim via a lncRNA Morrbid Regulates the Survival of Preleukemic and Leukemic Cells.
      Title: Targeting Bim via a lncRNA Morrbid Regulates the Survival of Preleukemic and Leukemic Cells.
    6. Murine Long Noncoding RNA Morrbid Contributes in the Regulation of NRAS Splicing in Hepatocytes In Vitro.
      Title: Murine Long Noncoding RNA Morrbid Contributes in the Regulation of NRAS Splicing in Hepatocytes In Vitro.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_028589.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AL844486, AL844586, AL845156
      Related
      ENSMUST00000239198.2

    2. NR_028590.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 3' terminal exon, compared to variant 1.
      Source sequence(s)
      AL844486, AL844586
      Related
      ENSMUST00000239221.3

    3. NR_028591.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 3' terminal exon, compared to variant 1.
      Source sequence(s)
      AL844486, AL844586

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      128140583..128271271 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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