U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Nrg2 neuregulin 2 [ Mus musculus (house mouse) ]

    Gene ID: 100042150, updated on 8-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Nrg2provided by MGI
    Official Full Name
    neuregulin 2provided by MGI
    Primary source
    MGI:MGI:1098246
    See related
    Ensembl:ENSMUSG00000060275 AllianceGenome:MGI:1098246
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Don1; NTAK
    Summary
    Predicted to enable ErbB-3 class receptor binding activity; epidermal growth factor receptor binding activity; and epidermal growth factor-activated receptor activity. Predicted to be involved in several processes, including epidermal growth factor receptor signaling pathway; intracellular signal transduction; and regulation of synapse organization. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in epidermis; heart; mammary gland primordium; nervous system; and surface ectoderm. Orthologous to human NRG2 (neuregulin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cerebellum adult (RPKM 3.5), ovary adult (RPKM 2.6) and 22 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Nrg2 in Genome Data Viewer
    Location:
    18 B2; 18 19.38 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (36147634..36332754, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (36014581..36197532, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C330008A17 gene Neighboring gene STARR-positive B cell enhancer ABC_E776 Neighboring gene predicted gene, 36416 Neighboring gene pleckstrin and Sec7 domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_44271 Neighboring gene STARR-seq mESC enhancer starr_44272 Neighboring gene predicted gene, 41694 Neighboring gene RIKEN cDNA 4930471G03 gene Neighboring gene STARR-seq mESC enhancer starr_44273 Neighboring gene STARR-seq mESC enhancer starr_44274 Neighboring gene STARR-seq mESC enhancer starr_44276 Neighboring gene predicted gene, 41695 Neighboring gene purine rich element binding protein A Neighboring gene IgA inducing protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Neuregulin-2 ablation results in dopamine dysregulation and severe behavioral phenotypes relevant to psychiatric disorders. Yan L, et al. Mol Psychiatry, 2018 May. PMID 28322273, Free PMC Article
    2. Generation and characterization of neuregulin-2-deficient mice. Britto JM, et al. Mol Cell Biol, 2004 Sep. PMID 15340081, Free PMC Article
    3. Neuregulin-2 is developmentally regulated and targeted to dendrites of central neurons. Longart M, et al. J Comp Neurol, 2004 Apr 26. PMID 15048684
    4. Bioactive recombinant neuregulin-1, -2, and -3 expressed in Escherichia coli. Mautino B, et al. Protein Expr Purif, 2004 May. PMID 15039062
    5. Characterization of the human NTAK gene structure and distribution of the isoforms for rat NTAK mRNA. Yamada K, et al. Gene, 2000 Sep 5. PMID 10974560

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Proteolytic Processing of Neuregulin 2.
      Title: Proteolytic Processing of Neuregulin 2.
    2. Findings reveal a novel role for NRG2 in the modulation of behaviors with relevance to psychiatric disorders.
      Title: Neuregulin-2 ablation results in dopamine dysregulation and severe behavioral phenotypes relevant to psychiatric disorders.
    3. Findings reveal an intimate reciprocal relationship between ErbB4 and GluN2b NMDA receptors via NRG2/ErbB4 signaling.
      Title: A negative feedback loop controls NMDA receptor function in cortical interneurons via neuregulin 2/ErbB4 signalling.
    4. in vivo NRG-2 activity differs substantially from that of NRG-1, and it is not essential for normal development
      Title: Generation and characterization of neuregulin-2-deficient mice.
    5. The distinct temporal, regional, and subcellular expression of NRG-2 in the developing brain suggests its unique and nonredundant role in neural function.
      Title: Neuregulin-2 is developmentally regulated and targeted to dendrites of central neurons.
    6. identify NRG2 as a factor capable of promoting subventricular zone proliferation, leading to the formation of new neurons in vivo
      Title: The role of neuregulin-ErbB4 interactions on the proliferation and organization of cells in the subventricular zone.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ErbB-3 class receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ErbB-4 class receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables epidermal growth factor receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables epidermal growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables receptor ligand activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables receptor ligand activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERBB2-ERBB3 signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ERBB4 signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ERBB4 signaling pathway IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in ERBB4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in ERBB4-ERBB4 signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in animal organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synapse maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    pro-neuregulin-2, membrane-bound isoform
    Names
    pro-NRG2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167891.3 → NP_001161363.3  pro-neuregulin-2, membrane-bound isoform isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC127350, AC131191, AC141471
      Consensus CDS
      CCDS50255.1
      UniProtKB/Swiss-Prot
      P56974
      UniProtKB/TrEMBL
      D3YZR2
      Related
      ENSMUSP00000111378.2, ENSMUST00000115713.9
      Conserved Domains (2) summary
      pfam02158
      Location:441 → 838
      Neuregulin; Neuregulin family
      cd05750
      Location:248 → 339
      Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins

    2. NM_001382420.1 → NP_001369349.1  pro-neuregulin-2, membrane-bound isoform isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC127350, AC131191, AC141471
      UniProtKB/Swiss-Prot
      P56974
      Conserved Domains (3) summary
      PHA02887
      Location:354 → 397
      PHA02887; EGF-like protein; Provisional
      pfam02158
      Location:443 → 840
      Neuregulin; Neuregulin family
      cd05750
      Location:248 → 339
      Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      36147634..36332754 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250231.2 → XP_030106091.1  pro-neuregulin-2, membrane-bound isoform isoform X3

      Conserved Domains (1) summary
      pfam02158
      Location:58 → 454
      Neuregulin; Neuregulin family

    2. XM_030250234.2 → XP_030106094.1  pro-neuregulin-2, membrane-bound isoform isoform X5

      Conserved Domains (1) summary
      pfam02158
      Location:47 → 443
      Neuregulin; Neuregulin family

    3. XM_011246789.3 → XP_011245091.1  pro-neuregulin-2, membrane-bound isoform isoform X2

      UniProtKB/TrEMBL
      A0A6I8MWW5
      Related
      ENSMUSP00000159288.2, ENSMUST00000239409.2
      Conserved Domains (3) summary
      cd05750
      Location:50 → 123
      Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins (NRGs)
      PHA02887
      Location:140 → 183
      PHA02887; EGF-like protein; Provisional
      pfam02158
      Location:229 → 625
      Neuregulin; Neuregulin family

    4. XM_030250232.1 → XP_030106092.1  pro-neuregulin-2, membrane-bound isoform isoform X4

      Conserved Domains (1) summary
      pfam02158
      Location:50 → 446
      Neuregulin; Neuregulin family

    5. XM_011246790.4 → XP_011245092.1  pro-neuregulin-2, membrane-bound isoform isoform X5

      See identical proteins and their annotated locations for XP_011245092.1

      Conserved Domains (1) summary
      pfam02158
      Location:47 → 443
      Neuregulin; Neuregulin family

    6. XM_006525462.5 → XP_006525525.1  pro-neuregulin-2, membrane-bound isoform isoform X1

      UniProtKB/Swiss-Prot
      P56974
      Conserved Domains (3) summary
      cd05750
      Location:264 → 337
      Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins (NRGs)
      PHA03099
      Location:340 → 428
      PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
      pfam02158
      Location:435 → 831
      Neuregulin; Neuregulin family

    7. XM_036160908.1 → XP_036016801.1  pro-neuregulin-2, membrane-bound isoform isoform X6

      Conserved Domains (1) summary
      pfam02158
      Location:39 → 436
      Neuregulin; Neuregulin family

    8. XM_006525466.5 → XP_006525529.1  pro-neuregulin-2, membrane-bound isoform isoform X7

      Conserved Domains (2) summary
      cd05750
      Location:264 → 337
      Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins (NRGs)
      PHA02887
      Location:354 → 394
      PHA02887; EGF-like protein; Provisional

    9. XM_011246792.4 → XP_011245094.1  pro-neuregulin-2, membrane-bound isoform isoform X8

      Conserved Domains (2) summary
      cd05750
      Location:264 → 337
      Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins (NRGs)
      PHA02887
      Location:354 → 394
      PHA02887; EGF-like protein; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P56974.1 GenPept UniProtKB/Swiss-Prot:P56974

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous