Tceal7 transcription elongation factor A (SII)-like 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tceal7provided by MGI
Official Full Name: transcription elongation factor A (SII)-like 7provided by MGI
Primary source: MGI:MGI:1915746
See related: Ensembl:ENSMUSG00000079428 AllianceGenome:MGI:1915746
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110018P05Rik
Summary: Predicted to enable WW domain binding activity. Predicted to be involved in negative regulation of NF-kappaB transcription factor activity and negative regulation of transcription, DNA-templated. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in tongue muscle and vertebral axis musculature. Orthologous to human TCEAL7 (transcription elongation factor A like 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in placenta adult (RPKM 22.5), limb E14.5 (RPKM 18.6) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: X F1; X 57.4 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (135124790..135126849)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (136224041..136226100)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tceal7 Regulates Skeletal Muscle Development through Its Interaction with Cdk1.
Title: Tceal7 Regulates Skeletal Muscle Development through Its Interaction with Cdk1.
Tceal5 and Tceal7 Function in C2C12 Myogenic Differentiation via Exosomes in Fetal Bovine Serum.
Title: Tceal5 and Tceal7 Function in C2C12 Myogenic Differentiation via Exosomes in Fetal Bovine Serum.
The studies support the hypothesis that MRFs transactivate Tceal7 gene expression and promote muscle differentiation during muscle development and regeneration.
Title: Myogenic regulatory factors transactivate the Tceal7 gene and modulate muscle differentiation.
These data implicate human TCEAL7 as a cell death regulatory protein that is frequently inactivated in ovarian cancers, and suggest that it may function as a tumor suppressor.
Title: Epigenetic silencing of TCEAL7 (Bex4) in ovarian cancer.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

AI118095 (e-PCR)
- UniSTS:166192

RH126864 (e-PCR)
- UniSTS:209752

RH136276 (e-PCR)
- UniSTS:210269

RH125734 (e-PCR)
- UniSTS:162492

Rex3 (e-PCR), detects polymorphism
- UniSTS:144347

RH125463 (e-PCR)
- UniSTS:162282

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transcription elongation factor A protein-like 7

Names: TCEA-like protein 7; transcription elongation factor S-II protein-like 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.