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TOMM70 translocase of outer mitochondrial membrane 70 [ Homo sapiens (human) ]

Gene ID: 9868, updated on 11-Apr-2024

Summary

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Official Symbol
TOMM70provided by HGNC
Official Full Name
translocase of outer mitochondrial membrane 70provided by HGNC
Primary source
HGNC:HGNC:11985
See related
Ensembl:ENSG00000154174 MIM:606081; AllianceGenome:HGNC:11985
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Tom70; TOMM70A
Summary
This gene encodes an import receptor of the outer mitochondrial membrane that is part of the translocase of the outer membrane complex. This protein is involved in the import of mitochondrial precursor proteins. The protein interacts with the SARS-CoV and SARS-Cov-2 ORF9b proteins. [provided by RefSeq, Dec 2021]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection.
Expression
Ubiquitous expression in brain (RPKM 23.1), thyroid (RPKM 20.6) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
3q12.2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (100363431..100401089, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (103068774..103106448, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (100082275..100119933, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene hESC enhancers GRCh37_chr3:99979240-99979908 and GRCh37_chr3:99979909-99980577 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:99981915-99982583 Neighboring gene TBC1 domain family member 23 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20153 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:100047046-100047276 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:100053369-100053937 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20154 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20155 Neighboring gene Sharpr-MPRA regulatory region 4023 Neighboring gene nitrilase family member 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:100118351-100119270 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20157 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14571 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20158 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20159 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:100126809-100127334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:100127335-100127860 Neighboring gene leukemia NUP98 fusion partner 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:100170016-100170553 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:100184868-100185368 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:100195719-100196404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14573 Neighboring gene transmembrane protein 45A Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:100280470-100281334

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Evolution of enhanced innate immune evasion by SARS-CoV-2. Thorne LG, et al. Nature, 2022 Feb. PMID 34942634, Free PMC Article
  2. SARS-CoV-2 structural coverage map reveals viral protein assembly, mimicry, and hijacking mechanisms. O'Donoghue SI, et al. Mol Syst Biol, 2021 Sep. PMID 34519429, Free PMC Article
  3. Mutations in TOMM70 lead to multi-OXPHOS deficiencies and cause severe anemia, lactic acidosis, and developmental delay. Wei X, et al. J Hum Genet, 2020 Mar. PMID 31907385
  4. Human mitochondrial import receptor Tom70 functions as a monomer. Fan AC, et al. Biochem J, 2010 Aug 1. PMID 20504278, Free PMC Article
  5. Characterization of a human import component of the mitochondrial outer membrane, TOMM70A. Edmonson AM, et al. Cell Commun Adhes, 2002 Jan-Feb. PMID 12200962

See all (107) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Orf9b protein of SARS-CoV-2 modulates mitochondrial protein biogenesis.
    Title: The Orf9b protein of SARS-CoV-2 modulates mitochondrial protein biogenesis.
  2. Mitochondria shed their outer membrane in response to infection-induced stress.
    Title: Mitochondria shed their outer membrane in response to infection-induced stress.
  3. Relation between ORF8a and the mitochondrial protein TOM70 in SARS-CoV-2 infection.
    Title: Relation between ORF8a and the mitochondrial protein TOM70 in SARS-CoV-2 infection.
  4. Phosphorylation of SARS-CoV-2 Orf9b Regulates Its Targeting to Two Binding Sites in TOM70 and Recruitment of Hsp90.
    Title: Phosphorylation of SARS-CoV-2 Orf9b Regulates Its Targeting to Two Binding Sites in TOM70 and Recruitment of Hsp90.
  5. De novo mutations in TOMM70, a receptor of the mitochondrial import translocase, cause neurological impairment.
    Title: De novo mutations in TOMM70, a receptor of the mitochondrial import translocase, cause neurological impairment.
  6. Crystal structure of SARS-CoV-2 Orf9b in complex with human TOM70 suggests unusual virus-host interactions.
    Title: Crystal structure of SARS-CoV-2 Orf9b in complex with human TOM70 suggests unusual virus-host interactions.
  7. Mutations in TOMM70 lead to multi-OXPHOS deficiencies and cause severe anemia, lactic acidosis, and developmental delay.
    Title: Mutations in TOMM70 lead to multi-OXPHOS deficiencies and cause severe anemia, lactic acidosis, and developmental delay.
  8. SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70.
    Title: SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70.
  9. TOM70, but not TOM20, clusters in distinct OMM foci, frequently overlapping with sites in which the endoplasmic reticulum (ER) contacts mitochondria. Functionally, TOM70 depletion specifically impairs inositol trisphosphates (IP3)-linked ER to mitochondria Ca(2+) transfer. This phenomenon is dependent on the capacity of TOM70 to interact with IP3-receptors and favor their functional recruitment close to mitochondria.
    Title: TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca(2+) Transfer.
  10. Collectively, this study characterizes a novel protein complex, Tom70/Hsp90/IRF3/Bax, that is important for Sendai virus-induced apoptosis.
    Title: Tom70 mediates Sendai virus-induced apoptosis on mitochondria.
Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of translocase of outer mitochondrial membrane 70 homolog A (TOMM70A) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ90470

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mitochondrion targeting sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mitochondrion targeting sequence binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables molecular adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to protein transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein transmembrane transporter activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of innate immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell growth involved in cardiac muscle cell development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of defense response to virus by host IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of interferon-beta production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein targeting to mitochondrion IEA
Inferred from Electronic Annotation
more info
  
involved_in protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein insertion into mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein insertion into mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein insertion into mitochondrial outer membrane NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein targeting to mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein targeting to mitochondrion TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to thyroxine IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of TOM complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in membrane HDA PubMed 
is_active_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrial outer membrane TAS
Traceable Author Statement
more info
  
part_of mitochondrial outer membrane translocase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of mitochondrial outer membrane translocase complex TAS
Traceable Author Statement
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mitochondrial import receptor subunit TOM70
Names
mitochondrial precursor proteins import receptor
translocase of outer membrane 70 kDa subunit
translocase of outer mitochondrial membrane 70 homolog A
translocase of outer mitochondrial membrane protein 70

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014820.5 → NP_055635.3  mitochondrial import receptor subunit TOM70

    See identical proteins and their annotated locations for NP_055635.3

    Status: REVIEWED

    Source sequence(s)
    AB018262, AC093003, AW044465, BC065555
    Consensus CDS
    CCDS33807.1
    UniProtKB/Swiss-Prot
    D3DN48, O94826
    UniProtKB/TrEMBL
    B4DZ87
    Related
    ENSP00000284320.5, ENST00000284320.6
    Conserved Domains (2) summary
    TIGR00990
    Location:41 → 601
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:114 → 142
    TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    100363431..100401089 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    103068774..103106448 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O94826.1 GenPept UniProtKB/Swiss-Prot:O94826

Gene LinkOut

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