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Strn4 striatin, calmodulin binding protein 4 [ Mus musculus (house mouse) ]

Gene ID: 97387, updated on 11-Apr-2024

Summary

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Official Symbol
Strn4provided by MGI
Official Full Name
striatin, calmodulin binding protein 4provided by MGI
Primary source
MGI:MGI:2142346
See related
Ensembl:ENSMUSG00000030374 AllianceGenome:MGI:2142346
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ZIN; zinedin
Summary
Predicted to enable armadillo repeat domain binding activity; calmodulin binding activity; and protein phosphatase 2A binding activity. Predicted to be located in dendritic spine. Predicted to be part of FAR/SIN/STRIPAK complex. Predicted to be active in dendrite. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and musculoskeletal system. Orthologous to human STRN4 (striatin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 50.8), CNS E18 (RPKM 43.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Strn4 in Genome Data Viewer
Location:
7 A2; 7 9.15 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (16549814..16574856)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (16815889..16840931)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4899 Neighboring gene STARR-positive B cell enhancer ABC_E6517 Neighboring gene adaptor-related protein complex 2, sigma 1 subunit Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:17351790-17352086 Neighboring gene STARR-positive B cell enhancer ABC_E694 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:17368547-17368700 Neighboring gene solute carrier family 1 (neutral amino acid transporter), member 5 Neighboring gene fukutin related protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:17426612-17426765 Neighboring gene STARR-positive B cell enhancer ABC_E9686 Neighboring gene STARR-positive B cell enhancer ABC_E4900 Neighboring gene protein kinase D2 Neighboring gene RIKEN cDNA 9330104G04 gene Neighboring gene STARR-positive B cell enhancer ABC_E3701

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain. Castets F, et al. J Biol Chem, 2000 Jun 30. PMID 10748158
  2. Functional consequences of necdin nucleocytoplasmic localization. Lavi-Itzkovitz A, et al. PLoS One, 2012. PMID 22442722, Free PMC Article
  3. Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain. Lee Y, et al. Biochem Biophys Res Commun, 2020 Aug 13. PMID 32560809
  4. Phosphoproteomic analysis of the developing mouse brain. Ballif BA, et al. Mol Cell Proteomics, 2004 Nov. PMID 15345747
  5. Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Munton RP, et al. Mol Cell Proteomics, 2007 Feb. PMID 17114649

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables armadillo repeat domain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables armadillo repeat domain binding ISO
Inferred from Sequence Orthology
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase 2A binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase 2A binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
part_of FAR/SIN/STRIPAK complex ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
striatin-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039878.2 → NP_001034967.1  striatin-4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal 7-aa segment, compared to isoform 1.
    Source sequence(s)
    AC148981, AK136155, BC066805
    Consensus CDS
    CCDS39787.1
    UniProtKB/TrEMBL
    Q3U3S0
    Related
    ENSMUSP00000104135.2, ENSMUST00000108495.9
    Conserved Domains (4) summary
    COG2319
    Location:416 → 746
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:430 → 752
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08232
    Location:64 → 189
    Striatin; Striatin family
    sd00039
    Location:443 → 489
    7WD40; WD40 repeat [structural motif]

  2. NM_133789.3 → NP_598550.2  striatin-4 isoform 1

    See identical proteins and their annotated locations for NP_598550.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC148981, BC066805, BC080283
    Consensus CDS
    CCDS39786.1
    UniProtKB/Swiss-Prot
    E9QKX6, P58404, Q68EF5
    UniProtKB/TrEMBL
    Q3U3S0
    Related
    ENSMUSP00000019220.9, ENSMUST00000019220.16
    Conserved Domains (4) summary
    COG2319
    Location:423 → 753
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:437 → 759
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08232
    Location:64 → 189
    Striatin; Striatin family
    sd00039
    Location:450 → 496
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    16549814..16574856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312409.2 → XP_017167898.1  striatin-4 isoform X3

    Conserved Domains (1) summary
    pfam08232
    Location:64 → 189
    Striatin; Striatin family

  2. XM_036153606.1 → XP_036009499.1  striatin-4 isoform X4

    Conserved Domains (1) summary
    pfam08232
    Location:65 → 189
    Striatin; Striatin family

  3. XM_006540446.3 → XP_006540509.1  striatin-4 isoform X1

    UniProtKB/TrEMBL
    Q3U3S0
    Conserved Domains (3) summary
    cd00200
    Location:318 → 640
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:331 → 377
    7WD40; WD40 repeat [structural motif]
    pfam08232
    Location:1 → 70
    Striatin; Striatin family

  4. XM_017312408.2 → XP_017167897.1  striatin-4 isoform X2

    UniProtKB/TrEMBL
    Q3U3S0
    Conserved Domains (3) summary
    cd00200
    Location:311 → 633
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:324 → 370
    7WD40; WD40 repeat [structural motif]
    pfam08232
    Location:1 → 70
    Striatin; Striatin family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P58404.2 GenPept UniProtKB/Swiss-Prot:P58404

Gene LinkOut

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