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Hecw1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 [ Mus musculus (house mouse) ]

Gene ID: 94253, updated on 11-Apr-2024

Summary

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Official Symbol
Hecw1provided by MGI
Official Full Name
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1provided by MGI
Primary source
MGI:MGI:2444115
See related
Ensembl:ENSMUSG00000021301 AllianceGenome:MGI:2444115
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nedl1; 9330116H24Rik; E130207I19Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular protein metabolic process; negative regulation of sodium ion transmembrane transporter activity; and regulation of dendrite morphogenesis. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in alimentary system; nervous system; sensory organ; and testis. Orthologous to human HECW1 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 6.7), whole brain E14.5 (RPKM 4.9) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 A1; 13 5.29 cM
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (14401023..14697874, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (14226438..14523289, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33710 Neighboring gene AT-rich interaction domain 4B Neighboring gene predicted gene, 26129 Neighboring gene zinc finger and SCAN domain containing 5B pseudogene Neighboring gene STARR-seq mESC enhancer starr_33711 Neighboring gene STARR-seq mESC enhancer starr_33713 Neighboring gene STARR-seq mESC enhancer starr_33714 Neighboring gene STARR-seq mESC enhancer starr_33715 Neighboring gene predicted gene, 30893 Neighboring gene STARR-seq mESC enhancer starr_33716 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 pseudogene Neighboring gene predicted gene, 32526

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Estrogen degrades Scribble in endometrial epithelial cells through E3 ubiquitin ligase HECW1 in the development of diffuse adenomyosis†. Jin Z, et al. Biol Reprod, 2020 Feb 14. PMID 31616916
  2. Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway. Inaba H, et al. J Cell Biol, 2016 Feb 15. PMID 26880200, Free PMC Article
  3. NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1. Miyazaki K, et al. J Biol Chem, 2004 Mar 19. PMID 14684739
  4. NEDL2 is an essential regulator of enteric neural development and GDNF/Ret signaling. Wei R, et al. Cell Signal, 2015 Mar. PMID 25555806
  5. NEDL2 regulates enteric nervous system and kidney development in its Nedd8 ligase activity-dependent manner. Qiu X, et al. Oncotarget, 2016 May 24. PMID 27119228, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ndel1 acts as a novel upstream regulator of the trichoplein-Aurora A pathway to inhibit primary cilia assembly.
    Title: Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of sodium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of dendrite morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase HECW1
Names
HECT type E3 ubiquitin ligase
HECT, C2 and WW domain-containing protein 1
HECT-type E3 ubiquitin transferase HECW1
NEDD4-like E3 ubiquitin-protein ligase 1
mNEDL1
NP_001074817.3
XP_006516872.1
XP_006516873.1
XP_006516874.1
XP_006516875.1
XP_006516876.1
XP_006516877.1
XP_006516878.1
XP_006516879.1
XP_017171138.1
XP_017171139.1
XP_017171140.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081348.3 → NP_001074817.3  E3 ubiquitin-protein ligase HECW1

    See identical proteins and their annotated locations for NP_001074817.3

    Status: VALIDATED

    Source sequence(s)
    AB083710, AK047678, AK172932, BB606770, CT025604
    Consensus CDS
    CCDS49207.1
    UniProtKB/Swiss-Prot
    D3YZ67, Q6A086, Q8BIA6, Q8BKC2, Q8BKL3, Q8BKZ8, Q8K4P8
    Related
    ENSMUSP00000106145.3, ENSMUST00000110516.3
    Conserved Domains (7) summary
    cd08691
    Location:205 → 341
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:1018 → 1049
    WW; Domain with 2 conserved Trp (W) residues
    cd00078
    Location:1248 → 1602
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    NF033609
    Location:421 → 798
    MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA
    pfam00397
    Location:828 → 857
    WW; WW domain
    pfam16562
    Location:65 → 182
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
    pfam18436
    Location:946 → 1012
    HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    14401023..14697874 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516816.4 → XP_006516879.1  E3 ubiquitin-protein ligase HECW1 isoform X7

    Conserved Domains (7) summary
    cd08691
    Location:206 → 342
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:971 → 1002
    WW; Domain with 2 conserved Trp (W) residues
    cd00078
    Location:1201 → 1555
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:783 → 810
    WW; WW domain
    pfam06614
    Location:378 → 500
    Neuromodulin
    pfam16562
    Location:66 → 185
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
    pfam18436
    Location:899 → 965
    HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

  2. XM_006516813.4 → XP_006516876.1  E3 ubiquitin-protein ligase HECW1 isoform X3

    Conserved Domains (7) summary
    cd08691
    Location:206 → 342
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:1005 → 1036
    WW; Domain with 2 conserved Trp (W) residues
    cd00078
    Location:1235 → 1589
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:815 → 844
    WW; WW domain
    pfam06614
    Location:378 → 500
    Neuromodulin
    pfam16562
    Location:66 → 185
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
    pfam18436
    Location:933 → 999
    HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

  3. XM_006516815.4 → XP_006516878.1  E3 ubiquitin-protein ligase HECW1 isoform X5

    Conserved Domains (7) summary
    cd08691
    Location:206 → 342
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:985 → 1016
    WW; Domain with 2 conserved Trp (W) residues
    cd00078
    Location:1215 → 1569
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:797 → 824
    WW; WW domain
    pfam06614
    Location:378 → 500
    Neuromodulin
    pfam16562
    Location:66 → 185
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
    pfam18436
    Location:913 → 979
    HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

  4. XM_006516809.4 → XP_006516872.1  E3 ubiquitin-protein ligase HECW1 isoform X1

    See identical proteins and their annotated locations for XP_006516872.1

    Conserved Domains (7) summary
    cd08691
    Location:206 → 342
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:1019 → 1050
    WW; Domain with 2 conserved Trp (W) residues
    cd00078
    Location:1249 → 1603
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:829 → 858
    WW; WW domain
    pfam06614
    Location:378 → 500
    Neuromodulin
    pfam16562
    Location:66 → 185
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
    pfam18436
    Location:947 → 1013
    HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

  5. XM_006516811.3 → XP_006516874.1  E3 ubiquitin-protein ligase HECW1 isoform X2

    See identical proteins and their annotated locations for XP_006516874.1

    UniProtKB/Swiss-Prot
    D3YZ67, Q6A086, Q8BIA6, Q8BKC2, Q8BKL3, Q8BKZ8, Q8K4P8
    Conserved Domains (7) summary
    cd08691
    Location:205 → 341
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:1018 → 1049
    WW; Domain with 2 conserved Trp (W) residues
    cd00078
    Location:1248 → 1602
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    NF033609
    Location:421 → 798
    MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA
    pfam00397
    Location:828 → 857
    WW; WW domain
    pfam16562
    Location:65 → 182
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
    pfam18436
    Location:946 → 1012
    HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

  6. XM_017315650.3 → XP_017171139.1  E3 ubiquitin-protein ligase HECW1 isoform X8

    Conserved Domains (7) summary
    cd08691
    Location:205 → 341
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:970 → 1001
    WW; Domain with 2 conserved Trp (W) residues
    cd00078
    Location:1200 → 1554
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:782 → 809
    WW; WW domain
    pfam06614
    Location:377 → 499
    Neuromodulin
    pfam16562
    Location:65 → 184
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
    pfam18436
    Location:898 → 964
    HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

  7. XM_017315649.3 → XP_017171138.1  E3 ubiquitin-protein ligase HECW1 isoform X6

    Conserved Domains (7) summary
    cd08691
    Location:205 → 341
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:984 → 1015
    WW; Domain with 2 conserved Trp (W) residues
    cd00078
    Location:1214 → 1568
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:796 → 823
    WW; WW domain
    pfam06614
    Location:377 → 499
    Neuromodulin
    pfam16562
    Location:65 → 184
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
    pfam18436
    Location:912 → 978
    HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

  8. XM_006516810.5 → XP_006516873.1  E3 ubiquitin-protein ligase HECW1 isoform X2

    See identical proteins and their annotated locations for XP_006516873.1

    UniProtKB/Swiss-Prot
    D3YZ67, Q6A086, Q8BIA6, Q8BKC2, Q8BKL3, Q8BKZ8, Q8K4P8
    Conserved Domains (7) summary
    cd08691
    Location:205 → 341
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:1018 → 1049
    WW; Domain with 2 conserved Trp (W) residues
    cd00078
    Location:1248 → 1602
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    NF033609
    Location:421 → 798
    MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA
    pfam00397
    Location:828 → 857
    WW; WW domain
    pfam16562
    Location:65 → 182
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
    pfam18436
    Location:946 → 1012
    HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

  9. XM_017315651.2 → XP_017171140.1  E3 ubiquitin-protein ligase HECW1 isoform X9

    Conserved Domains (7) summary
    cd08691
    Location:184 → 320
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:963 → 994
    WW; Domain with 2 conserved Trp (W) residues
    cd00078
    Location:1193 → 1547
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:775 → 802
    WW; WW domain
    pfam06614
    Location:356 → 478
    Neuromodulin
    pfam16562
    Location:44 → 163
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
    pfam18436
    Location:891 → 957
    HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

  10. XM_006516814.4 → XP_006516877.1  E3 ubiquitin-protein ligase HECW1 isoform X4

    See identical proteins and their annotated locations for XP_006516877.1

    Conserved Domains (7) summary
    cd08691
    Location:184 → 320
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:997 → 1028
    WW; Domain with 2 conserved Trp (W) residues
    cd00078
    Location:1227 → 1581
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:807 → 836
    WW; WW domain
    pfam06614
    Location:356 → 478
    Neuromodulin
    pfam16562
    Location:44 → 163
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
    pfam18436
    Location:925 → 991
    HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

  11. XM_006516812.5 → XP_006516875.1  E3 ubiquitin-protein ligase HECW1 isoform X2

    See identical proteins and their annotated locations for XP_006516875.1

    UniProtKB/Swiss-Prot
    D3YZ67, Q6A086, Q8BIA6, Q8BKC2, Q8BKL3, Q8BKZ8, Q8K4P8
    Conserved Domains (7) summary
    cd08691
    Location:205 → 341
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:1018 → 1049
    WW; Domain with 2 conserved Trp (W) residues
    cd00078
    Location:1248 → 1602
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    NF033609
    Location:421 → 798
    MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA
    pfam00397
    Location:828 → 857
    WW; WW domain
    pfam16562
    Location:65 → 182
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
    pfam18436
    Location:946 → 1012
    HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_153130.2: Suppressed sequence

    Description
    NM_153130.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.

  2. NM_178809.1: Suppressed sequence

    Description
    NM_178809.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K4P8.3 GenPept UniProtKB/Swiss-Prot:Q8K4P8

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