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Ddx50 DExD box helicase 50 [ Mus musculus (house mouse) ]

Gene ID: 94213, updated on 7-May-2024

Summary

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Official Symbol
Ddx50provided by MGI
Official Full Name
DExD box helicase 50provided by MGI
Primary source
MGI:MGI:2182303
See related
Ensembl:ENSMUSG00000020076 AllianceGenome:MGI:2182303
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GU2; RH-II; 4933429B04Rik; 8430408E17Rik
Summary
Predicted to enable RNA binding activity and RNA helicase activity. Predicted to be located in plasma membrane. Predicted to be active in nucleolus. Is expressed in embryo. Orthologous to human DDX50 (DExD-box helicase 50). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 26.0), bladder adult (RPKM 19.0) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 B4; 10 32.44 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (62451571..62487260, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (62615792..62658764, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26888 Neighboring gene kinesin family binding protein Neighboring gene STARR-positive B cell enhancer ABC_E3889 Neighboring gene STARR-positive B cell enhancer ABC_E8339 Neighboring gene DExD box helicase 21 Neighboring gene STARR-positive B cell enhancer ABC_E10615 Neighboring gene STARR-seq mESC enhancer starr_26889 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:62114124-62114233 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:62127774-62127957 Neighboring gene predicted gene, 51417 Neighboring gene storkhead box 1 Neighboring gene crumbs homolog 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genomic structure of newly identified paralogue of RNA helicase II/Gu: detection of pseudogenes and multiple alternatively spliced mRNAs. Valdez BC, et al. Gene, 2002 Feb 6. PMID 11891046
  2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  3. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
  4. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article
  5. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ATP-dependent RNA helicase DDX50
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
DEAD box protein 50
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 50
RH-II/Gubeta
gu-beta
nucleolar protein GU2
NP_001345748.1
NP_001345749.1
NP_444413.1
XP_006514408.1
XP_011241910.1
XP_030101267.1
XP_030101268.1
XP_030101269.1
XP_030101270.1
XP_036012018.1
XP_036012019.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358819.1 → NP_001345748.1  ATP-dependent RNA helicase DDX50 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC121961, AK041281, AK162423
    UniProtKB/TrEMBL
    Q5BKP5, Q8BRU5
    Conserved Domains (3) summary
    COG0513
    Location:65 → 543
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd12936
    Location:500 → 591
    GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins
    cd17944
    Location:80 → 281
    DEADc_DDX21_DDX50; DEAD-box helicase domain of DEAD box proteins 21 and 50

  2. NM_001358820.1 → NP_001345749.1  ATP-dependent RNA helicase DDX50 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK030239, AK041281, CF898436
    UniProtKB/TrEMBL
    Q5BKP5, Q8BRU5
    Related
    ENSMUST00000218372.2
    Conserved Domains (3) summary
    COG0513
    Location:65 → 543
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd12936
    Location:500 → 591
    GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins
    cd17944
    Location:80 → 281
    DEADc_DDX21_DDX50; DEAD-box helicase domain of DEAD box proteins 21 and 50

  3. NM_053183.3 → NP_444413.1  ATP-dependent RNA helicase DDX50 isoform 1

    See identical proteins and their annotated locations for NP_444413.1

    Status: VALIDATED

    Source sequence(s)
    AC121961, AK041281, AK162423
    Consensus CDS
    CCDS23892.1
    UniProtKB/Swiss-Prot
    Q99MJ9
    UniProtKB/TrEMBL
    Q5BKP5
    Related
    ENSMUSP00000020270.5, ENSMUST00000020270.6
    Conserved Domains (4) summary
    COG0513
    Location:130 → 608
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd00079
    Location:369 → 486
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:136 → 339
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    cd12936
    Location:565 → 656
    GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    62451571..62487260 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514345.5 → XP_006514408.1  ATP-dependent RNA helicase DDX50 isoform X1

    UniProtKB/TrEMBL
    Q5BKP5
    Conserved Domains (3) summary
    COG0513
    Location:130 → 554
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd12936
    Location:511 → 602
    GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins
    cd17944
    Location:145 → 346
    DEADc_DDX21_DDX50; DEAD-box helicase domain of DEAD box proteins 21 and 50

  2. XM_030245409.2 → XP_030101269.1  ATP-dependent RNA helicase DDX50 isoform X3

    Conserved Domains (3) summary
    COG0513
    Location:65 → 489
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd12936
    Location:446 → 537
    GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins
    cd17944
    Location:80 → 281
    DEADc_DDX21_DDX50; DEAD-box helicase domain of DEAD box proteins 21 and 50

  3. XM_011243608.4 → XP_011241910.1  ATP-dependent RNA helicase DDX50 isoform X4

    Conserved Domains (2) summary
    COG0513
    Location:1 → 317
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd12936
    Location:274 → 365
    GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins

  4. XM_030245410.2 → XP_030101270.1  ATP-dependent RNA helicase DDX50 isoform X4

    Conserved Domains (2) summary
    COG0513
    Location:1 → 317
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd12936
    Location:274 → 365
    GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins

  5. XM_036156125.1 → XP_036012018.1  ATP-dependent RNA helicase DDX50 isoform X4

    Conserved Domains (2) summary
    COG0513
    Location:1 → 317
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd12936
    Location:274 → 365
    GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins

  6. XM_036156126.1 → XP_036012019.1  ATP-dependent RNA helicase DDX50 isoform X5

    Conserved Domains (3) summary
    COG0513
    Location:1 → 263
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd12936
    Location:220 → 311
    GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins
    cl28899
    Location:1 → 55
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  7. XM_030245408.2 → XP_030101268.1  ATP-dependent RNA helicase DDX50 isoform X2

    UniProtKB/TrEMBL
    Q5BKP5, Q8BRU5
    Conserved Domains (3) summary
    COG0513
    Location:65 → 543
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd12936
    Location:500 → 591
    GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins
    cd17944
    Location:80 → 281
    DEADc_DDX21_DDX50; DEAD-box helicase domain of DEAD box proteins 21 and 50

  8. XM_030245407.2 → XP_030101267.1  ATP-dependent RNA helicase DDX50 isoform X2

    UniProtKB/TrEMBL
    Q5BKP5, Q8BRU5
    Conserved Domains (3) summary
    COG0513
    Location:65 → 543
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd12936
    Location:500 → 591
    GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins
    cd17944
    Location:80 → 281
    DEADc_DDX21_DDX50; DEAD-box helicase domain of DEAD box proteins 21 and 50
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99MJ9.1 GenPept UniProtKB/Swiss-Prot:Q99MJ9

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