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Acsbg1 acyl-CoA synthetase bubblegum family member 1 [ Mus musculus (house mouse) ]

Gene ID: 94180, updated on 5-Mar-2024

Summary

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Official Symbol
Acsbg1provided by MGI
Official Full Name
acyl-CoA synthetase bubblegum family member 1provided by MGI
Primary source
MGI:MGI:2385656
See related
Ensembl:ENSMUSG00000032281 AllianceGenome:MGI:2385656
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BG1; Bgm; Lpd; GR-LACS; E230019G03Rik
Summary
Predicted to enable long-chain fatty acid-CoA ligase activity and very long-chain fatty acid-CoA ligase activity. Acts upstream of or within response to glucocorticoid. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; face; genitourinary system; integumental system; and skeleton. Human ortholog(s) of this gene implicated in adrenoleukodystrophy. Orthologous to human ACSBG1 (acyl-CoA synthetase bubblegum family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 280.6), adrenal adult (RPKM 69.5) and 4 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A5.3; 9 29.7 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (54512163..54569169, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (54604886..54661885, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene SH2 domain containing 7 Neighboring gene calcium and integrin binding family member 2 Neighboring gene STARR-positive B cell enhancer ABC_E888 Neighboring gene STARR-seq mESC enhancer starr_24171 Neighboring gene isocitrate dehydrogenase 3 (NAD+) alpha Neighboring gene predicted gene, 51677 Neighboring gene predicted gene, 39341 Neighboring gene 5730494N06Rik pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Acsbg1-dependent mitochondrial fitness is a metabolic checkpoint for tissue T(reg) cell homeostasis. Kanno T, et al. Cell Rep, 2021 Nov 9. PMID 34758300
  2. The gonadotropin-regulated long-chain acyl CoA synthetase gene: a novel downstream Sp1/Sp3 binding element critical for transcriptional promoter activity. Sheng Y, et al. Gene, 2005 Oct 24. PMID 16125341
  3. Lessons from the gonadotropin-regulated long chain acyl-CoA synthetase (GR-LACS) null mouse model: a role in steroidogenesis, but not result in X-ALD phenotype. Sheng Y, et al. J Steroid Biochem Mol Biol, 2009 Mar. PMID 19167491
  4. Expression of an acyl-CoA synthetase, lipidosin, in astrocytes of the murine brain and its up-regulation during remyelination following cuprizone-induced demyelination. Song SY, et al. J Neurosci Res, 2007 Dec. PMID 17722065
  5. The acyl-CoA synthetase "bubblegum" (lipidosin): further characterization and role in neuronal fatty acid beta-oxidation. Pei Z, et al. J Biol Chem, 2003 Nov 21. PMID 12975357

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Acsbg1-dependent mitochondrial fitness is a metabolic checkpoint for tissue Treg cell homeostasis.
    Title: Acsbg1-dependent mitochondrial fitness is a metabolic checkpoint for tissue T(reg) cell homeostasis.
  2. These data suggest that lipidosin was involved in fatty acid metabolism during reconstruction of the myelin sheath.
    Title: Expression of an acyl-CoA synthetase, lipidosin, in astrocytes of the murine brain and its up-regulation during remyelination following cuprizone-induced demyelination.
  3. Expression pattern and localization of bubblegum to microsomes.
    Title: Murine bubblegum orthologue is a microsomal very long-chain acyl-CoA synthetase.
  4. in neurons, mBG1-activated long-chain fatty acids are directed toward mitochondrial degradation
    Title: The acyl-CoA synthetase "bubblegum" (lipidosin): further characterization and role in neuronal fatty acid beta-oxidation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (7) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0631

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables long-chain fatty acid-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables long-chain fatty acid-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables very long-chain fatty acid-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables very long-chain fatty acid-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in long-chain fatty acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within response to glucocorticoid IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in very long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in very long-chain fatty acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
NOT located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
NOT located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
NOT located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
long-chain-fatty-acid--CoA ligase ACSBG1
Names
bubblegum
gonadotropin-regulated long chain acyl CoA synthetase
lipidosin
lipidosis-related protein lipidosin
lipodisin
NP_444408.1
XP_006511651.1
XP_030100613.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053178.2 → NP_444408.1  long-chain-fatty-acid--CoA ligase ACSBG1

    See identical proteins and their annotated locations for NP_444408.1

    Status: VALIDATED

    Source sequence(s)
    AC157591
    Consensus CDS
    CCDS23192.1
    UniProtKB/Swiss-Prot
    Q6ZQ79, Q99PU5
    Related
    ENSMUSP00000034822.6, ENSMUST00000034822.12
    Conserved Domains (2) summary
    cd05933
    Location:122 → 716
    ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)
    COG1022
    Location:100 → 719
    FAA1; Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    54512163..54569169 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244753.2 → XP_030100613.1  long-chain-fatty-acid--CoA ligase ACSBG1 isoform X1

    Conserved Domains (1) summary
    cd05933
    Location:155 → 749
    ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)

  2. XM_006511588.4 → XP_006511651.1  long-chain-fatty-acid--CoA ligase ACSBG1 isoform X2

    Conserved Domains (1) summary
    cd05933
    Location:131 → 725
    ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99PU5.1 GenPept UniProtKB/Swiss-Prot:Q99PU5

Gene LinkOut

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