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Cpn1 carboxypeptidase N, polypeptide 1 [ Mus musculus (house mouse) ]

Gene ID: 93721, updated on 11-Apr-2024

Summary

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Official Symbol
Cpn1provided by MGI
Official Full Name
carboxypeptidase N, polypeptide 1provided by MGI
Primary source
MGI:MGI:2135874
See related
Ensembl:ENSMUSG00000025196 AllianceGenome:MGI:2135874
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CPN; 0610011F20Rik
Summary
Enables carboxypeptidase activity. Predicted to be involved in bradykinin catabolic process; protein processing; and response to glucocorticoid. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including gonad; gut; liver; neural tube; and yolk sac. Human ortholog(s) of this gene implicated in carboxypeptidase N deficiency. Orthologous to human CPN1 (carboxypeptidase N subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 130.6), liver E18 (RPKM 106.8) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 C3; 19 36.68 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (43944746..43974990, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (43956307..43986551, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene dynamin binding protein Neighboring gene predicted gene, 24400 Neighboring gene STARR-seq mESC enhancer starr_46211 Neighboring gene RIKEN cDNA 4933403J19 gene Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 23 Neighboring gene STARR-seq mESC enhancer starr_46217 Neighboring gene ER lipid raft associated 1 Neighboring gene uracil DNA glycosylase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Carboxypeptidase N-deficient mice present with polymorphic disease phenotypes on induction of experimental autoimmune encephalomyelitis. Hu X, et al. Immunobiology, 2014 Feb. PMID 24028840, Free PMC Article
  2. Deletion of carboxypeptidase N delays onset of experimental cerebral malaria. Darley MM, et al. Parasite Immunol, 2012 Aug-Sep. PMID 22708514, Free PMC Article
  3. Characterization of mouse carboxypeptidase N small active subunit gene structure. Matthews KW, et al. J Immunol, 2001 May 15. PMID 11342641
  4. Both plasma basic carboxypeptidases, carboxypeptidase B2 and carboxypeptidase N, regulate vascular leakage activity in mice. Zhou Q, et al. J Thromb Haemost, 2022 Jan. PMID 34626062
  5. Expression of the third complement component (C3) and carboxypeptidase N small subunit (CPN1) during mouse embryonic development. Matthews KW, et al. Dev Comp Immunol, 2004 May 17. PMID 15177117

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Both plasma basic carboxypeptidases, carboxypeptidase B2 and carboxypeptidase N, regulate vascular leakage activity in mice.
    Title: Both plasma basic carboxypeptidases, carboxypeptidase B2 and carboxypeptidase N, regulate vascular leakage activity in mice.
  2. plays a role in experimental autoimmune encephalomyelitis development and progression
    Title: Carboxypeptidase N-deficient mice present with polymorphic disease phenotypes on induction of experimental autoimmune encephalomyelitis.
  3. These results indicate that carboxypeptidases contribute to the pathogenesis of experimental cerebral malaria.
    Title: Deletion of carboxypeptidase N delays onset of experimental cerebral malaria.
  4. we report the generation of a mouse with complete CPN deficiency by targeted disruption of the CPN1 gene
    Title: Targeted disruption of the gene encoding the murine small subunit of carboxypeptidase N (CPN1) causes susceptibility to C5a anaphylatoxin-mediated shock.
  5. carboxypeptidase N regulates the biologic activity of SDF-1alpha by reducing the chemokine-specific activity
    Title: Identification of carboxypeptidase N as an enzyme responsible for C-terminal cleavage of stromal cell-derived factor-1alpha in the circulation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxypeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carboxypeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in bradykinin catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in peptide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in response to glucocorticoid ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
carboxypeptidase N catalytic chain
Names
anaphylatoxin inactivator
carboxypeptidase N small subunit
carboxypeptidase N, polypeptide 1, 50kD
kininase I
NP_109628.1
XP_011245709.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030703.2 → NP_109628.1  carboxypeptidase N catalytic chain precursor

    See identical proteins and their annotated locations for NP_109628.1

    Status: VALIDATED

    Source sequence(s)
    AF326477
    Consensus CDS
    CCDS29840.1
    UniProtKB/Swiss-Prot
    Q91WM9, Q9JJN5
    Related
    ENSMUSP00000026210.5, ENSMUST00000026210.5
    Conserved Domains (2) summary
    cd11308
    Location:341 → 415
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    cl11393
    Location:25 → 337
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    43944746..43974990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247407.1 → XP_011245709.1  carboxypeptidase N catalytic chain isoform X1

    Conserved Domains (2) summary
    cd11308
    Location:347 → 421
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    cl11393
    Location:25 → 343
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JJN5.1 GenPept UniProtKB/Swiss-Prot:Q9JJN5

Gene LinkOut

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