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Il24 interleukin 24 [ Mus musculus (house mouse) ]

Gene ID: 93672, updated on 21-Apr-2024

Summary

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Official Symbol
Il24provided by MGI
Official Full Name
interleukin 24provided by MGI
Primary source
MGI:MGI:2135548
See related
Ensembl:ENSMUSG00000026420 AllianceGenome:MGI:2135548
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FISP; If2e; Mda7; St16; Mda-7
Summary
Predicted to enable cytokine activity. Acts upstream of or within negative regulation of cell population proliferation; positive regulation of apoptotic process; and regulation of cysteine-type endopeptidase activity involved in apoptotic process. Located in endoplasmic reticulum and extracellular region. Is expressed in alimentary system; brain; gonad; hemolymphoid system gland; and metanephros. Orthologous to human IL24 (interleukin 24). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
1 E4; 1 56.89 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (130809801..130815153, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (130882074..130887411, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene polymeric immunoglobulin receptor Neighboring gene STARR-positive B cell enhancer ABC_E9184 Neighboring gene STARR-positive B cell enhancer ABC_E9478 Neighboring gene Fc fragment of IgM receptor Neighboring gene STARR-seq mESC enhancer starr_02206 Neighboring gene interleukin 20 Neighboring gene interleukin 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A tissue injury sensing and repair pathway distinct from host pathogen defense. Liu S, et al. Cell, 2023 May 11. PMID 37098344, Free PMC Article
  2. Interleukin 24 promotes cell death in renal epithelial cells and is associated with acute renal injury. Schütte-Nütgen K, et al. Am J Transplant, 2022 Nov. PMID 35801504
  3. Interleukin-24 protects against liver injury in mouse models. Wang HH, et al. EBioMedicine, 2021 Feb. PMID 33508745, Free PMC Article
  4. Interleukin-24 is a novel diagnostic biomarker for the severity of acute kidney injury. Tabata T, et al. Med Mol Morphol, 2020 Jun. PMID 31802235
  5. Murine astrocytes produce IL-24 and are susceptible to the immunosuppressive effects of this cytokine. Burmeister AR, et al. J Neuroinflammation, 2019 Mar 2. PMID 30825881, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Spinal interleukin-24 contributes to neuropathic pain after peripheral nerve injury through interleukin-20 receptor2 in mice.
    Title: Spinal interleukin-24 contributes to neuropathic pain after peripheral nerve injury through interleukin-20 receptor2 in mice.
  2. A tissue injury sensing and repair pathway distinct from host pathogen defense.
    Title: A tissue injury sensing and repair pathway distinct from host pathogen defense.
  3. Interleukin 24 promotes cell death in renal epithelial cells and is associated with acute renal injury.
    Title: Interleukin 24 promotes cell death in renal epithelial cells and is associated with acute renal injury.
  4. Methyltransferase-like 3 leads to lung injury by up-regulation of interleukin 24 through N6-methyladenosine-dependent mRNA stability and translation efficiency in mice exposed to fine particulate matter 2.5.
    Title: Methyltransferase-like 3 leads to lung injury by up-regulation of interleukin 24 through N6-methyladenosine-dependent mRNA stability and translation efficiency in mice exposed to fine particulate matter 2.5.
  5. IL-24 intrinsically regulates Th17 cell pathogenicity in mice.
    Title: IL-24 intrinsically regulates Th17 cell pathogenicity in mice.
  6. Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24.
    Title: Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24.
  7. IL-24 deficiency protects mice against bleomycin-induced pulmonary fibrosis by repressing IL-4-induced M2 program in macrophages.
    Title: IL-24 deficiency protects mice against bleomycin-induced pulmonary fibrosis by repressing IL-4-induced M2 program in macrophages.
  8. Interleukin-24 protects against liver injury in mouse models.
    Title: Interleukin-24 protects against liver injury in mouse models.
  9. Interleukin-24 regulates mucosal remodeling in inflammatory bowel diseases.
    Title: Interleukin-24 regulates mucosal remodeling in inflammatory bowel diseases.
  10. The Cytokine IL-17A Limits Th17 Pathogenicity via a Negative Feedback Loop Driven by Autocrine Induction of IL-24.
    Title: The Cytokine IL-17A Limits Th17 Pathogenicity via a Negative Feedback Loop Driven by Autocrine Induction of IL-24.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
interleukin-24
Names
IL-24
IL-4-induced secreted protein
interferon 2e
melanoma differentiation-associated gene 7 protein
th2-specific cytokine FISP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053095.3 → NP_444325.3  interleukin-24 precursor

    Status: VALIDATED

    Source sequence(s)
    AC165322
    Consensus CDS
    CCDS15262.2
    UniProtKB/Swiss-Prot
    Q925J3, Q925S4
    UniProtKB/TrEMBL
    A0A087WQD7, A0A0R4J1N5
    Related
    ENSMUSP00000113064.3, ENSMUST00000121040.8
    Conserved Domains (1) summary
    cl02501
    Location:33 → 175
    IL10; Interleukin 10

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    130809801..130815153 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q925S4.1 GenPept UniProtKB/Swiss-Prot:Q925S4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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