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SRSF11 serine and arginine rich splicing factor 11 [ Homo sapiens (human) ]

Gene ID: 9295, updated on 3-Apr-2024

Summary

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Official Symbol
SRSF11provided by HGNC
Official Full Name
serine and arginine rich splicing factor 11provided by HGNC
Primary source
HGNC:HGNC:10782
See related
Ensembl:ENSG00000116754 MIM:602010; AllianceGenome:HGNC:10782
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p54; NET2; SFRS11; dJ677H15.2
Summary
This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing. Alternative splicing results in multiple transcript variants encoding different proteins. In addition, a pseudogene of this gene has been found on chromosome 12.[provided by RefSeq, Sep 2010]
Expression
Ubiquitous expression in bone marrow (RPKM 46.2), skin (RPKM 32.0) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
1p31.1
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (70205696..70253052)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (70084212..70131570)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (70671379..70718735)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 7 Neighboring gene NANOG hESC enhancer GRCh37_chr1:70503542-70504181 Neighboring gene LRRC7 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:70534982-70535190 Neighboring gene Sharpr-MPRA regulatory region 9273 Neighboring gene NANOG hESC enhancer GRCh37_chr1:70606447-70606948 Neighboring gene Sharpr-MPRA regulatory region 3760 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:70626481-70626982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1187 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1186 Neighboring gene leucine rich repeat containing 40 Neighboring gene RNA, 7SL, cytoplasmic 242, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:70686957-70687502 Neighboring gene MPRA-validated peak281 silencer Neighboring gene ankyrin repeat domain 13C Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:70818812-70820011 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:70820190-70821107 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1193 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:70826052-70826245 Neighboring gene ANKRD13C divergent transcript Neighboring gene long intergenic non-protein coding RNA 3102

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Regulation of gene expression programmes by serine-arginine rich splicing factors. Änkö ML. Semin Cell Dev Biol, 2014 Aug. PMID 24657192
  2. Microtubule interfering agents and KSP inhibitors induce the phosphorylation of the nuclear protein p54(nrb), an event linked to G2/M arrest. Casado P, et al. J Proteomics, 2009 Jan 30. PMID 18832053
  3. Primary structure of a human arginine-rich nuclear protein that colocalizes with spliceosome components. Chaudhary N, et al. Proc Natl Acad Sci U S A, 1991 Sep 15. PMID 1896467, Free PMC Article
  4. METTL3-mediated downregulation of splicing factor SRSF11 is associated with carcinogenesis and poor survival of cancer patients. Oh J, et al. Eur Rev Med Pharmacol Sci, 2023 Mar. PMID 37013774
  5. Alternative splicing of HSPA12A pre-RNA by SRSF11 contributes to metastasis potential of colorectal cancer. Pan YJ, et al. Clin Transl Med, 2022 Nov. PMID 36394206, Free PMC Article

See all (108) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. METTL3-mediated downregulation of splicing factor SRSF11 is associated with carcinogenesis and poor survival of cancer patients.
    Title: METTL3-mediated downregulation of splicing factor SRSF11 is associated with carcinogenesis and poor survival of cancer patients.
  2. Alternative splicing of HSPA12A pre-RNA by SRSF11 contributes to metastasis potential of colorectal cancer.
    Title: Alternative splicing of HSPA12A pre-RNA by SRSF11 contributes to metastasis potential of colorectal cancer.
  3. Regulation of gene expression programmes by serine-arginine rich splicing factors.
    Title: Regulation of gene expression programmes by serine-arginine rich splicing factors.
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  5. The G2/M arrest induced by MIAs is required for p54(nrb) phosphorylation. CDK activity is required for MIA-induced phosphorylation of p54(nrb).
    Title: Microtubule interfering agents and KSP inhibitors induce the phosphorylation of the nuclear protein p54(nrb), an event linked to G2/M arrest.
  6. SRp54 interacts with a purine-rich element tau in exon 10 and antagonizes Tra2beta, an SR-domain-containing protein that enhances exon 10 inclusion.
    Title: SRp54 (SFRS11), a regulator for tau exon 10 alternative splicing identified by an expression cloning strategy.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ18226, DKFZp686M13204

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nuclear speck IDA
Inferred from Direct Assay
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
serine/arginine-rich splicing factor 11
Names
SR splicing factor 11
arginine-rich 54 kDa nuclear protein
splicing factor p54
splicing factor, arginine/serine-rich 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190987.3 → NP_001177916.1  serine/arginine-rich splicing factor 11 isoform 2

    See identical proteins and their annotated locations for NP_001177916.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses alternate splice sites in the 3' coding region and 5' UTR, compared to variant 1, and encodes an isoform (2) that is one aa shorter than isoform 1. Variants 2 and 5 encode the same protein (isoform 2).
    Source sequence(s)
    AI002238, AL832279, BC022815, BC040436, BF680379, BG494115, CN294419
    Consensus CDS
    CCDS53332.1
    UniProtKB/Swiss-Prot
    Q05519
    Related
    ENSP00000359989.1, ENST00000370951.5
    Conserved Domains (1) summary
    cd12518
    Location:34 → 113
    RRM_SRSF11; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

  2. NM_001350605.2 → NP_001337534.1  serine/arginine-rich splicing factor 11 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AI002238, AL832279, BF680379, BG494115, CN294419, DA157431, DC415520, M74002
    Consensus CDS
    CCDS647.1
    UniProtKB/Swiss-Prot
    Q05519, Q5T758, Q8IWE6
    Related
    ENSP00000359987.2, ENST00000370949.2
    Conserved Domains (1) summary
    cd12518
    Location:34 → 113
    RRM_SRSF11; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

  3. NM_001350606.2 → NP_001337535.1  serine/arginine-rich splicing factor 11 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AI002238, AL832279, BC022815, BF680379, BG494115, CB996573, CN294419, M74002
    Consensus CDS
    CCDS647.1
    UniProtKB/Swiss-Prot
    Q05519, Q5T758, Q8IWE6
    Conserved Domains (1) summary
    cd12518
    Location:34 → 113
    RRM_SRSF11; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

  4. NM_001350607.2 → NP_001337536.1  serine/arginine-rich splicing factor 11 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AI002238, AL832279, BC022815, BC040436, BF680379, BG494115, CN294419, M74002
    Consensus CDS
    CCDS53332.1
    Conserved Domains (1) summary
    cd12518
    Location:34 → 113
    RRM_SRSF11; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

  5. NM_001350608.2 → NP_001337537.1  serine/arginine-rich splicing factor 11 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AI002238, AL832279, BC022815, BF680379, BG494115, CN294419, CX869063, M74002
    Consensus CDS
    CCDS90976.1
    UniProtKB/TrEMBL
    Q5T760
    Related
    ENSP00000378568.3, ENST00000395136.7
    Conserved Domains (1) summary
    cd12518
    Location:34 → 113
    RRM_SRSF11; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

  6. NM_001350609.2 → NP_001337538.1  serine/arginine-rich splicing factor 11 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AI002238, AL832279, BC022815, BF680379, BG494115, BG612368, CB996573, CN294419, CX869063, M74002
    Conserved Domains (1) summary
    cd12518
    Location:34 → 113
    RRM_SRSF11; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

  7. NM_001350610.2 → NP_001337539.1  serine/arginine-rich splicing factor 11 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AI002238, AL353771, BF680379, BG494115, BM716576, BP290987, CA417788, CN294419, CX869063, DA157431, DA581964, DC415520
    UniProtKB/TrEMBL
    Q6MZM2

  8. NM_001350611.2 → NP_001337540.1  serine/arginine-rich splicing factor 11 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AI002238, AL353771, AL532192, BF680379, BG494115, BM716576, BP290987, CA417788, CN294419, CX869063, DA157431, DA581964, DC415520

  9. NM_001350612.2 → NP_001337541.1  serine/arginine-rich splicing factor 11 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AI002238, AL353771, AL532192, BF680379, BG494115, BM716576, CA417788, CN294419, DA157431, DA581964, DC415520
    UniProtKB/TrEMBL
    Q6MZM2

  10. NM_001350613.2 → NP_001337542.1  serine/arginine-rich splicing factor 11 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AI002238, AL353771, AL532192, BF680379, BG494115, BM716576, CA417788, CN294419, DA157431, DA581964, DC415520
    UniProtKB/TrEMBL
    Q6MZM2

  11. NM_001350614.2 → NP_001337543.1  serine/arginine-rich splicing factor 11 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AI002238, AL353771, AL532192, BF680379, BG494115, BM716576, BP290987, CA417788, CN294419, DA157431, DA581964, DC415520
    UniProtKB/TrEMBL
    Q6MZM2

  12. NM_001350615.2 → NP_001337544.1  serine/arginine-rich splicing factor 11 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AI002238, AL353771, AL532192, BF680379, BG494115, BM716576, BP290987, CA417788, CN294419, CX869063, DA157431, DA581964, DC415520
    UniProtKB/TrEMBL
    Q6MZM2

  13. NM_001350616.2 → NP_001337545.1  serine/arginine-rich splicing factor 11 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AI002238, AL353771, AL532192, BF680379, BG494115, BM716576, BP290987, CA417788, CN294419, DA157431, DA581964, DC415520
    UniProtKB/TrEMBL
    Q6MZM2

  14. NM_001394402.1 → NP_001381331.1  serine/arginine-rich splicing factor 11 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL353771
    Conserved Domains (1) summary
    smart00360
    Location:34 → 118
    RRM; RNA recognition motif

  15. NM_001394403.1 → NP_001381332.1  serine/arginine-rich splicing factor 11 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL353771
    Conserved Domains (1) summary
    smart00360
    Location:34 → 118
    RRM; RNA recognition motif

  16. NM_001394404.1 → NP_001381333.1  serine/arginine-rich splicing factor 11 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL353771
    Consensus CDS
    CCDS90976.1
    UniProtKB/TrEMBL
    Q5T760
    Conserved Domains (1) summary
    cd12518
    Location:34 → 113
    RRM_SRSF11; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

  17. NM_001394405.1 → NP_001381334.1  serine/arginine-rich splicing factor 11 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL353771
    Conserved Domains (1) summary
    cd12518
    Location:34 → 113
    RRM_SRSF11; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

  18. NM_001394406.1 → NP_001381335.1  serine/arginine-rich splicing factor 11 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL353771
    Consensus CDS
    CCDS647.1
    UniProtKB/Swiss-Prot
    Q05519, Q5T758, Q8IWE6
    Conserved Domains (1) summary
    cd12518
    Location:34 → 113
    RRM_SRSF11; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

  19. NM_001394407.1 → NP_001381336.1  serine/arginine-rich splicing factor 11 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL353771
    Consensus CDS
    CCDS53332.1
    Conserved Domains (1) summary
    cd12518
    Location:34 → 113
    RRM_SRSF11; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

  20. NM_001394408.1 → NP_001381337.1  serine/arginine-rich splicing factor 11 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL353771
    Consensus CDS
    CCDS53332.1
    Conserved Domains (1) summary
    cd12518
    Location:34 → 113
    RRM_SRSF11; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

  21. NM_004768.5 → NP_004759.1  serine/arginine-rich splicing factor 11 isoform 1

    See identical proteins and their annotated locations for NP_004759.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 3, and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AI002238, AL832279, BC022815, BF680379, BG494115, CN294419, M74002
    Consensus CDS
    CCDS647.1
    UniProtKB/Swiss-Prot
    Q05519, Q5T758, Q8IWE6
    Related
    ENSP00000359988.3, ENST00000370950.7
    Conserved Domains (1) summary
    cd12518
    Location:34 → 113
    RRM_SRSF11; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

RNA

  1. NR_146810.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AI002238, AL832279, BF680379, BG494115, BP290987, CD687855, CN294419, DA157431, DC415520, M74002

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    70205696..70253052
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434514.1 → XP_047290470.1  serine/arginine-rich splicing factor 11 isoform X1

    UniProtKB/TrEMBL
    Q5T760

  2. XM_047434518.1 → XP_047290474.1  serine/arginine-rich splicing factor 11 isoform X2

  3. XM_047434523.1 → XP_047290479.1  serine/arginine-rich splicing factor 11 isoform X3

    UniProtKB/Swiss-Prot
    Q05519, Q5T758, Q8IWE6

  4. XM_047434524.1 → XP_047290480.1  serine/arginine-rich splicing factor 11 isoform X4

  5. XM_047434516.1 → XP_047290472.1  serine/arginine-rich splicing factor 11 isoform X1

    UniProtKB/TrEMBL
    Q5T760

  6. XM_047434517.1 → XP_047290473.1  serine/arginine-rich splicing factor 11 isoform X1

    UniProtKB/TrEMBL
    Q5T760

  7. XM_047434522.1 → XP_047290478.1  serine/arginine-rich splicing factor 11 isoform X2

  8. XM_047434541.1 → XP_047290497.1  serine/arginine-rich splicing factor 11 isoform X7

  9. XM_047434536.1 → XP_047290492.1  serine/arginine-rich splicing factor 11 isoform X6

    UniProtKB/TrEMBL
    Q5T757

  10. XM_024450906.2 → XP_024306674.1  serine/arginine-rich splicing factor 11 isoform X5

    UniProtKB/TrEMBL
    Q6N079

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    70084212..70131570
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339634.1 → XP_054195609.1  serine/arginine-rich splicing factor 11 isoform X1

    UniProtKB/TrEMBL
    Q5T760

  2. XM_054339637.1 → XP_054195612.1  serine/arginine-rich splicing factor 11 isoform X2

  3. XM_054339639.1 → XP_054195614.1  serine/arginine-rich splicing factor 11 isoform X3

    UniProtKB/Swiss-Prot
    Q05519, Q5T758, Q8IWE6

  4. XM_054339640.1 → XP_054195615.1  serine/arginine-rich splicing factor 11 isoform X4

  5. XM_054339635.1 → XP_054195610.1  serine/arginine-rich splicing factor 11 isoform X1

    UniProtKB/TrEMBL
    Q5T760

  6. XM_054339636.1 → XP_054195611.1  serine/arginine-rich splicing factor 11 isoform X1

    UniProtKB/TrEMBL
    Q5T760

  7. XM_054339638.1 → XP_054195613.1  serine/arginine-rich splicing factor 11 isoform X2

  8. XM_054339645.1 → XP_054195620.1  serine/arginine-rich splicing factor 11 isoform X7

  9. XM_054339644.1 → XP_054195619.1  serine/arginine-rich splicing factor 11 isoform X6

    UniProtKB/TrEMBL
    Q5T757

  10. XM_054339642.1 → XP_054195617.1  serine/arginine-rich splicing factor 11 isoform X5

  11. XM_054339641.1 → XP_054195616.1  serine/arginine-rich splicing factor 11 isoform X5

  12. XM_054339643.1 → XP_054195618.1  serine/arginine-rich splicing factor 11 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05519.1 GenPept UniProtKB/Swiss-Prot:Q05519

Gene LinkOut

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