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NEK9 NIMA related kinase 9 [ Homo sapiens (human) ]

Gene ID: 91754, updated on 7-Apr-2024

Summary

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Official Symbol
NEK9provided by HGNC
Official Full Name
NIMA related kinase 9provided by HGNC
Primary source
HGNC:HGNC:18591
See related
Ensembl:ENSG00000119638 MIM:609798; AllianceGenome:HGNC:18591
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NC; APUG; NERCC; LCCS10; NERCC1
Summary
This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein is activated in mitosis and, in turn, activates other family members during mitosis. This protein also mediates cellular processes that are essential for interphase progression. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in ovary (RPKM 24.4), testis (RPKM 21.8) and 25 other tissues See more
Orthologs
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Genomic context

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See NEK9 in Genome Data Viewer
Location:
14q24.3
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (75079353..75127202, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (69288752..69338522, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (75546056..75593751, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 689, pseudogene Neighboring gene mutL homolog 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5939 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8735 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:75535987-75536538 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:75536539-75537090 Neighboring gene acylphosphatase 1 Neighboring gene zinc finger C2HC-type containing 1C Neighboring gene ReSE screen-validated silencer GRCh37_chr14:75565767-75565964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8736 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8737 Neighboring gene HIF1AP pseudogene 1 Neighboring gene transmembrane p24 trafficking protein 10 Neighboring gene Sharpr-MPRA regulatory regions 714 and 744 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75619067-75619731 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:75643139-75643711 Neighboring gene RNA, U4atac small nuclear 14, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Three novel pathogenic NEK9 variants in patients with nevus comedonicus: A case series. Juratli HA, et al. J Am Acad Dermatol, 2022 Apr. PMID 33819539
  2. NEK9, a novel effector of IL-6/STAT3, regulates metastasis of gastric cancer by targeting ARHGEF2 phosphorylation. Lu G, et al. Theranostics, 2021. PMID 33500736, Free PMC Article
  3. Decreased Nek9 expression correlates with aggressive behaviour and predicts unfavourable prognosis in breast cancer. Xu Z, et al. Pathology, 2020 Apr. PMID 32098687
  4. Somatic Mutations in NEK9 Cause Nevus Comedonicus. Levinsohn JL, et al. Am J Hum Genet, 2016 May 5. PMID 27153399, Free PMC Article
  5. The Dual Nature of Nek9 in Adenovirus Replication. Jung R, et al. J Virol, 2016 Feb 15. PMID 26676776, Free PMC Article

See all (104) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart.
    Title: NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart.
  2. Study on the Expression of lncRNA ATB and Nek9 in Breast Cancer Patients Based on Q-PCR Technology and Its Relationship with the Disease.
    Title: Study on the Expression of lncRNA ATB and Nek9 in Breast Cancer Patients Based on Q-PCR Technology and Its Relationship with the Disease.
  3. Three novel pathogenic NEK9 variants in patients with nevus comedonicus: A case series.
    Title: Three novel pathogenic NEK9 variants in patients with nevus comedonicus: A case series.
  4. NEK9, a novel effector of IL-6/STAT3, regulates metastasis of gastric cancer by targeting ARHGEF2 phosphorylation.
    Title: NEK9, a novel effector of IL-6/STAT3, regulates metastasis of gastric cancer by targeting ARHGEF2 phosphorylation.
  5. The short isoform of PRLR suppresses the pentose phosphate pathway and nucleotide synthesis through the NEK9-Hippo axis in pancreatic cancer.
    Title: The short isoform of PRLR suppresses the pentose phosphate pathway and nucleotide synthesis through the NEK9-Hippo axis in pancreatic cancer.
  6. EML4-ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7.
    Title: EML4-ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7.
  7. Decreased Nek9 expression correlates with aggressive behaviour and predicts unfavourable prognosis in breast cancer.
    Title: Decreased Nek9 expression correlates with aggressive behaviour and predicts unfavourable prognosis in breast cancer.
  8. NIMA-related kinase 9-mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1.
    Title: NIMA-related kinase 9-mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1.
  9. This study supports a role for NEK9 and MAP2K4 in mediating buparlisib resistance and demonstrates the value of unbiased omic analyses in uncovering resistance mechanisms to targeted therapy in Triple-Negative Breast Cancers.
    Title: Mass Spectrometry-Based Proteomics Reveals Potential Roles of NEK9 and MAP2K4 in Resistance to PI3K Inhibition in Triple-Negative Breast Cancers.
  10. Eg5 localization and centrosome separation in prophase depend on the nuclear microtubule-associated protein TPX2, a pool of which localizes to the centrosomes before nuclear envelope breakdown. This localization involves the kinase Nek9, which phosphorylates TPX2 nuclear localization signal preventing its interaction with importin and nuclear import.
    Title: Nek9 Phosphorylation Defines a New Role for TPX2 in Eg5-Dependent Centrosome Separation before Nuclear Envelope Breakdown.
Submit: New GeneRIF Correction See all GeneRIFs (29)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Arthrogryposis, Perthes disease, and upward gaze palsy
MedGen: C3280309 OMIM: 614262 GeneReviews: Not available
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NEK9-related lethal skeletal dysplasia
MedGen: C5568141 OMIM: 617022 GeneReviews: Not available
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Nevus comedonicus syndrome
MedGen: C0265987 OMIM: 617025 GeneReviews: Not available
Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of NIMA-related kinase 9 (NEK9) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC16714, MGC138306, DKFZp434D0935

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
colocalizes_with centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase Nek9
Names
NIMA (never in mitosis gene a)- related kinase 9
nercc1 kinase
nimA-related protein kinase 9
NP_001316166.1
NP_001316167.1
NP_149107.4
XP_005268266.1
XP_047287875.1
XP_054232953.1
XP_054232954.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051093.2 RefSeqGene

    Range
    5154..52849
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001329237.2 → NP_001316166.1  serine/threonine-protein kinase Nek9 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL049780
    Consensus CDS
    CCDS91908.1
    UniProtKB/TrEMBL
    A0A7I2V5R1
    Related
    ENSP00000504620.1, ENST00000678037.1
    Conserved Domains (3) summary
    smart00220
    Location:52 → 308
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08221
    Location:51 → 308
    STKc_Nek9; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 9
    pfam00415
    Location:444 → 495
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  2. NM_001329238.2 → NP_001316167.1  serine/threonine-protein kinase Nek9 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL049780
    Consensus CDS
    CCDS91907.1
    UniProtKB/TrEMBL
    A0A7I2V454
    Related
    ENSP00000503827.1, ENST00000678531.1

  3. NM_033116.6 → NP_149107.4  serine/threonine-protein kinase Nek9 isoform 2

    See identical proteins and their annotated locations for NP_149107.4

    Status: REVIEWED

    Source sequence(s)
    AL049780
    Consensus CDS
    CCDS9839.1
    UniProtKB/Swiss-Prot
    Q52LK6, Q8NCN0, Q8TCY4, Q8TD19, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6
    Related
    ENSP00000238616.5, ENST00000238616.10
    Conserved Domains (3) summary
    smart00220
    Location:52 → 308
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08221
    Location:51 → 308
    STKc_Nek9; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 9
    pfam00415
    Location:500 → 547
    RCC1; Regulator of chromosome condensation (RCC1) repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    75079353..75127202 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431919.1 → XP_047287875.1  serine/threonine-protein kinase Nek9 isoform X2

    UniProtKB/TrEMBL
    A0A7I2V454
    Related
    ENSP00000504104.1, ENST00000678749.1

  2. XM_005268209.4 → XP_005268266.1  serine/threonine-protein kinase Nek9 isoform X1

    Conserved Domains (2) summary
    cl21453
    Location:1 → 190
    PKc_like; Protein Kinases, catalytic domain
    cl27697
    Location:227 → 582
    RCC1; Regulator of chromosome condensation (RCC1) repeat

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    69288752..69338522 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054376979.1 → XP_054232954.1  serine/threonine-protein kinase Nek9 isoform X2

  2. XM_054376978.1 → XP_054232953.1  serine/threonine-protein kinase Nek9 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TD19.2 GenPept UniProtKB/Swiss-Prot:Q8TD19

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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