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TRPA1 transient receptor potential cation channel subfamily A member 1 [ Homo sapiens (human) ]

Gene ID: 8989, updated on 11-Apr-2024

Summary

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Official Symbol
TRPA1provided by HGNC
Official Full Name
transient receptor potential cation channel subfamily A member 1provided by HGNC
Primary source
HGNC:HGNC:497
See related
Ensembl:ENSG00000104321 MIM:604775; AllianceGenome:HGNC:497
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FEPS; p120; FEPS1; ANKTM1
Summary
The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008]
Expression
Biased expression in urinary bladder (RPKM 5.8), colon (RPKM 2.2) and 5 other tissues See more
Orthologs
mouse all
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Genomic context

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See TRPA1 in Genome Data Viewer
Location:
8q21.11
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (72021250..72090010, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (72456370..72525074, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (72933485..72987819, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:72753440-72754300 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19278 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19279 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27522 Neighboring gene MSC antisense RNA 1 Neighboring gene musculin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27523 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19280 Neighboring gene ribosomal protein S20 pseudogene 20 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27525 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:72945660-72946859 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:72987624-72988195 Neighboring gene uncharacterized LOC124901962 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:73064806-73065399 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27526 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27527 Neighboring gene transient receptor potential cation channel subfamily A member 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Molecular mechanism of hyperactivation conferred by a truncation of TRPA1. Bali A, et al. Nat Commun, 2023 May 19. PMID 37208332, Free PMC Article
  2. Transient Receptor Potential Ankyrin 1 (TRPA1) Channel as a Sensor of Oxidative Stress in Cancer Cells. Moccia F, et al. Cells, 2023 Apr 26. PMID 37174661, Free PMC Article
  3. Transient Receptor Potential Ankyrin 1 (TRPA1) Methylation and Chronic Pain: A Systematic Review. Celsi F, et al. Genes (Basel), 2023 Feb 4. PMID 36833338, Free PMC Article
  4. Isolation of human TRPA1 channel from transfected HEK293 cells and identification of alkylation sites after sulfur mustard exposure. Müller-Dott K, et al. Arch Toxicol, 2023 Feb. PMID 36371551, Free PMC Article
  5. The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain. Moparthi L, et al. Nat Commun, 2022 Oct 17. PMID 36253390, Free PMC Article

See all (223) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Discovery of PRDM16-Mediated TRPA1 Induction as the Mechanism for Low Tubulo-Interstitial Fibrosis in Diabetic Kidney Disease.
    Title: Discovery of PRDM16-Mediated TRPA1 Induction as the Mechanism for Low Tubulo-Interstitial Fibrosis in Diabetic Kidney Disease.
  2. Canine, mouse, and human transient receptor potential ankyrin 1 (TRPA1) channels show different sensitivity to menthol or cold stimulation.
    Title: Canine, mouse, and human transient receptor potential ankyrin 1 (TRPA1) channels show different sensitivity to menthol or cold stimulation.
  3. Functional TRPA1 Channels Regulate CD56[dim]CD16[+] NK Cell Cytotoxicity against Tumor Cells.
    Title: Functional TRPA1 Channels Regulate CD56(dim)CD16(+) NK Cell Cytotoxicity against Tumor Cells.
  4. [TRPA1 channel mediates oxidative stress defense in cancer].
    Title: [TRPA1 channel mediates oxidative stress defense in cancer].
  5. Alkali cation-mediated topology displayed by an exonic G-rich sequence of TRPA1 gene.
    Title: Alkali cation-mediated topology displayed by an exonic G-rich sequence of TRPA1 gene.
  6. TRPA1: A promising target for pulmonary fibrosis?
    Title: TRPA1: A promising target for pulmonary fibrosis?
  7. Transient Receptor Potential Ankyrin 1 (TRPA1) Channel Mediates Acrolein Cytotoxicity in Human Lung Cancer Cells.
    Title: Transient Receptor Potential Ankyrin 1 (TRPA1) Channel Mediates Acrolein Cytotoxicity in Human Lung Cancer Cells.
  8. Epigenetic Connections of the TRPA1 Ion Channel in Pain Transmission and Neurogenic Inflammation - a Therapeutic Perspective in Migraine?
    Title: Epigenetic Connections of the TRPA1 Ion Channel in Pain Transmission and Neurogenic Inflammation - a Therapeutic Perspective in Migraine?
  9. Functional expression of the thermally activated transient receptor potential channels TRPA1 and TRPM8 in human myotubes.
    Title: Functional expression of the thermally activated transient receptor potential channels TRPA1 and TRPM8 in human myotubes.
  10. TRPA1 rare variants in chronic neuropathic and nociplastic pain patients.
    Title: TRPA1 rare variants in chronic neuropathic and nociplastic pain patients.
Submit: New GeneRIF Correction See all GeneRIFs (228)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Familial episodic pain syndrome with predominantly upper body involvement
MedGen: C3808667 OMIM: 615040 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium channel activity TAS
Traceable Author Statement
more info
  
enables channel activity TAS
Traceable Author Statement
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables intracellularly gated calcium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables intracellularly gated calcium channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables temperature-gated cation channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in calcium ion transmembrane transport TAS
Traceable Author Statement
more info
  
involved_in calcium-mediated signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to organic substance IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of pain IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of mechanical stimulus involved in sensory perception of pain IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular calcium ion homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoatomic ion transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein homotetramerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to cold IEA
Inferred from Electronic Annotation
more info
  
involved_in response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
  
involved_in response to organic substance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to pain IEA
Inferred from Electronic Annotation
more info
  
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in thermoception IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in stereocilium bundle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transient receptor potential cation channel subfamily A member 1
Names
ankyrin-like with transmembrane domains 1
transformation-sensitive protein p120
wasabi receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033890.1 RefSeqGene

    Range
    5001..59335
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_007332.3 → NP_015628.2  transient receptor potential cation channel subfamily A member 1

    See identical proteins and their annotated locations for NP_015628.2

    Status: REVIEWED

    Source sequence(s)
    AC016057, AC022867
    Consensus CDS
    CCDS34908.1
    UniProtKB/Swiss-Prot
    A6NIN6, O75762
    UniProtKB/TrEMBL
    H0YAW0
    Related
    ENSP00000262209.4, ENST00000262209.5
    Conserved Domains (5) summary
    COG0666
    Location:416 → 623
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:97 → 128
    ANK; ANK repeat [structural motif]
    pfam00520
    Location:796 → 972
    Ion_trans; Ion transport protein
    pfam12796
    Location:486 → 577
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:80 → 374
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    72021250..72090010 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517625.3 → XP_011515927.1  transient receptor potential cation channel subfamily A member 1 isoform X2

    See identical proteins and their annotated locations for XP_011515927.1

    UniProtKB/Swiss-Prot
    A6NIN6, O75762
    UniProtKB/TrEMBL
    H0YAW0
    Conserved Domains (5) summary
    COG0666
    Location:416 → 623
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:97 → 128
    ANK; ANK repeat [structural motif]
    pfam00520
    Location:796 → 972
    Ion_trans; Ion transport protein
    pfam12796
    Location:486 → 577
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:80 → 374
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_011517624.3 → XP_011515926.1  transient receptor potential cation channel subfamily A member 1 isoform X1

    Conserved Domains (5) summary
    cd00204
    Location:120 → 243
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00520
    Location:769 → 997
    Ion_trans; Ion transport protein
    pfam12796
    Location:511 → 602
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:91 → 143
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:122 → 153
    ANK; ANK repeat [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    72456370..72525074 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361455.1 → XP_054217430.1  transient receptor potential cation channel subfamily A member 1 isoform X1

  2. XM_054361456.1 → XP_054217431.1  transient receptor potential cation channel subfamily A member 1 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75762.3 GenPept UniProtKB/Swiss-Prot:O75762

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