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aprI alkaline proteinase inhibitor AprI [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 881261, updated on 6-Oct-2023

Summary

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Gene symbol
aprI
Gene description
alkaline proteinase inhibitor AprI
Locus tag
PA1250
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Genomic context

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Sequence:
NC_002516.2 (1357317..1357712)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene alkaline protease secretion protein AprF Neighboring gene alkaline metalloproteinase Neighboring gene chemotaxis transducer Neighboring gene bifunctional Delta(1)-pyrroline-2-carboxylate/Delta(1)-piperideine-2-carboxylate reductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. NMR structure note: alkaline proteinase inhibitor APRin from Pseudomonas aeruginosa. Arumugam S, et al. J Biomol NMR, 2008 Mar. PMID 18214691
  2. Contribution of a single-turn alpha-helix to the conformational stability and activity of the alkaline proteinase inhibitor of Pseudomonas aeruginosa. Gray RD, et al. Biochemistry, 2005 Feb 22. PMID 15709759
  3. Inhibition of Pseudomonas aeruginosa virulence: characterization of the AprA-AprI interface and species selectivity. Bardoel BW, et al. J Mol Biol, 2012 Jan 20. PMID 22154939
  4. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
  5. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural and mutational studies reveal that the conserved N-terminal residues of AprI occupy the protease active site and are essential for AprA inhibitory activity.
    Title: Inhibition of Pseudomonas aeruginosa virulence: characterization of the AprA-AprI interface and species selectivity.
  2. NMR structure of alkaline proteinase inhibitor APRin from Pseudomonas aeruginosa.
    Title: NMR structure note: alkaline proteinase inhibitor APRin from Pseudomonas aeruginosa.
  3. A conserved single turn helix found in the APR inhibitor-proteinase complex strongly influences the global stability of the inhibitor protein.
    Title: Contribution of a single-turn alpha-helix to the conformational stability and activity of the alkaline proteinase inhibitor of Pseudomonas aeruginosa.
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General gene information

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Homology

General protein information

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Preferred Names
alkaline proteinase inhibitor AprI
NP_249941.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    1357317..1357712
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_249941.1 alkaline proteinase inhibitor AprI [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_249941.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A367LZJ5
    Conserved Domains (1) summary
    pfam02974
    Location:30 → 126
    Inh; Protease inhibitor Inh
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03026.1

Gene LinkOut

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Research Materials