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atg5 autophagy protein 5 [ Dictyostelium discoideum AX4 ]

Gene ID: 8627395, updated on 11-Apr-2024

Summary

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Gene symbol
atg5
Gene description
autophagy protein 5
Primary source
dictyBase:DDB_G0289881
Locus tag
DDB_G0289881
Gene type
protein coding
RNA name
autophagy protein 5
RefSeq status
PROVISIONAL
Organism
Dictyostelium discoideum AX4 (strain: AX4)
Lineage
Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium
Old locus tag
DDBDRAFT_0188643; DDBDRAFT_0191390; DDB_0188643; DDB_0191390
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Genomic context

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Location:
chromosome: 5
Exon count:
3
Sequence:
Chromosome: 5; NC_007091.3 (3433996..3435424)

Chromosome 5 - NC_007091.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene arsenite transport subunit B Neighboring gene C2 calcium/lipid-binding region-containing protein Neighboring gene UDP-glucose pyrophosphorylase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_007091.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Characterisation of the Autophagy ATG12~5/16 Complex in Dictyostelium discoideum. Karow M, et al. Cells, 2020 May 9. PMID 32397394, Free PMC Article
  2. Cyclic AMP induction of Dictyostelium prespore gene expression requires autophagy. Yamada Y, et al. Dev Biol, 2019 Aug 15. PMID 31051160, Free PMC Article
  3. The autophagic machinery ensures nonlytic transmission of mycobacteria. Gerstenmaier L, et al. Proc Natl Acad Sci U S A, 2015 Feb 17. PMID 25646440, Free PMC Article
  4. Macroautophagy is required for multicellular development of the social amoeba Dictyostelium discoideum. Otto GP, et al. J Biol Chem, 2003 May 16. PMID 12626495
  5. Dissecting the function of Atg1 complex in Dictyostelium autophagy reveals a connection with the pentose phosphate pathway enzyme transketolase. Mesquita A, et al. Open Biol, 2015 Aug. PMID 26246495, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by dictyBase

Function Evidence Code Pubs
contributes_to Atg8-family ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to nitrogen starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to nitrogen starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phagocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in piecemeal microautophagy of the nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within pinocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein lipidation involved in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to bacterium HEP PubMed 
acts_upstream_of_or_within sorocarp development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sorocarp morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sorocarp sorus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sporulation resulting in formation of a cellular spore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Atg12-Atg5-Atg16 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Atg12-Atg5-Atg16 complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondria-associated endoplasmic reticulum membrane contact site IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in phagophore IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in phagophore assembly site membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagophore assembly site membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Names
autophagy protein 5

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007091.3 Reference assembly

    Range
    3433996..3435424
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_630888.1 → XP_635980.1  autophagy protein 5 [Dictyostelium discoideum AX4]

    See identical proteins and their annotated locations for XP_635980.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q54GT9, Q86CS1
    Conserved Domains (1) summary
    pfam04106
    Location:80 → 382
    APG5; Autophagy protein Apg5
Nucleotide Protein
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