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KHSRP KH-type splicing regulatory protein [ Homo sapiens (human) ]

Gene ID: 8570, updated on 5-May-2024

Summary

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Official Symbol
KHSRPprovided by HGNC
Official Full Name
KH-type splicing regulatory proteinprovided by HGNC
Primary source
HGNC:HGNC:6316
See related
Ensembl:ENSG00000088247 MIM:603445; AllianceGenome:HGNC:6316
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p75; FBP2; KSRP; FUBP2
Summary
The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010]
Expression
Ubiquitous expression in testis (RPKM 37.2), endometrium (RPKM 25.1) and 25 other tissues See more
Orthologs
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Genomic context

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See KHSRP in Genome Data Viewer
Location:
19p13.3
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (6413102..6424811, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (6401987..6413694, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (6413113..6424822, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene general transcription factor IIF subunit 1 Neighboring gene adenylate kinase isoenzyme 1-like Neighboring gene microRNA 6790 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6411708-6412532 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6412533-6413357 Neighboring gene microRNA 3940 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13824 Neighboring gene solute carrier family 25 member 41 Neighboring gene solute carrier family 25 member 23 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9950 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9951 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9952 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6464149-6464690 Neighboring gene DENN domain containing 1C Neighboring gene crumbs cell polarity complex component 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. RNA-binding protein KHSRP promotes tumor growth and metastasis in non-small cell lung cancer. Yan M, et al. J Exp Clin Cancer Res, 2019 Nov 27. PMID 31775888, Free PMC Article
  2. The RNA-Binding Protein KSRP Modulates Cytokine Expression of CD4(+) T Cells. Käfer R, et al. J Immunol Res, 2019. PMID 31511826, Free PMC Article
  3. KH-Type Splicing Regulatory Protein Controls Colorectal Cancer Cell Growth and Modulates the Tumor Microenvironment. Caiazza F, et al. Am J Pathol, 2019 Oct. PMID 31404541, Free PMC Article
  4. KSRP modulates melanoma growth and efficacy of vemurafenib. Liu W, et al. Biochim Biophys Acta Gene Regul Mech, 2019 Aug. PMID 31269460, Free PMC Article
  5. Overexpression of KH-type splicing regulatory protein regulates proliferation, migration, and implantation ability of osteosarcoma. Pruksakorn D, et al. Int J Oncol, 2016 Sep. PMID 27573585, Free PMC Article

See all (227) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The RNA-binding protein KSRP aggravates malignant progression of clear cell renal cell carcinoma through transcriptional inhibition and post-transcriptional destabilization of the NEDD4L ubiquitin ligase.
    Title: The RNA-binding protein KSRP aggravates malignant progression of clear cell renal cell carcinoma through transcriptional inhibition and post-transcriptional destabilization of the NEDD4L ubiquitin ligase.
  2. Intergenic CircRNA Circ_0007379 Inhibits Colorectal Cancer Progression by Modulating miR-320a Biogenesis in a KSRP-Dependent Manner.
    Title: Intergenic CircRNA Circ_0007379 Inhibits Colorectal Cancer Progression by Modulating miR-320a Biogenesis in a KSRP-Dependent Manner.
  3. Identification of KHSRP-Regulated RNAs in Esophageal Cancer by Integrated Bioinformatics Analysis.
    Title: Identification of KHSRP-Regulated RNAs in Esophageal Cancer by Integrated Bioinformatics Analysis.
  4. Inhibition of KHSRP sensitizes colorectal cancer to 5-fluoruracil through miR-501-5p-mediated ERRFI1 mRNA degradation.
    Title: Inhibition of KHSRP sensitizes colorectal cancer to 5-fluoruracil through miR-501-5p-mediated ERRFI1 mRNA degradation.
  5. In NSCLC cell lines, overexpression of HNRNPC significantly promoted lung cancer cell proliferation, migration, and invasion in vitro and in vivo. KHSRP and HNRNPC may induce human lung cancer cell invasion and metastasis by activating the IFN-alpha-JAK-STAT1 signaling pathway.
    Title: RNA-binding protein KHSRP promotes tumor growth and metastasis in non-small cell lung cancer.
  6. High KHSRP expression is associated with Colorectal Cancer Cell Growth.
    Title: KH-Type Splicing Regulatory Protein Controls Colorectal Cancer Cell Growth and Modulates the Tumor Microenvironment.
  7. This is the first report demonstrating that KSRP is involved in the regulation of T cell responses. We present strong evidence that T cells derived from KSRP(-/-) mice favor Th2-driven immune responses.
    Title: The RNA-Binding Protein KSRP Modulates Cytokine Expression of CD4(+) T Cells.
  8. Results show that KSRP expression is significantly up-regulated in human melanoma. It modulates melanoma cell growth by repressing the expression of KLLN through mRNA decay and interaction with the AU-rich elements in the 3' UTR.
    Title: KSRP modulates melanoma growth and efficacy of vemurafenib.
  9. The KH-type splicing regulatory protein (KSRP) regulates type III interferon expression post-transcriptionally.
    Title: The KH-type splicing regulatory protein (KSRP) regulates type III interferon expression post-transcriptionally.
  10. Decreased expression of KHSRP, thus increasing CDKN1a (p21) expression.
    Title: Long Noncoding RNA AB074169 Inhibits Cell Proliferation via Modulation of KHSRP-Mediated CDKN1a Expression in Papillary Thyroid Carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (48)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify KH-type splicing regulatory protein (KHSRP; FUBP2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify KH-type splicing regulatory protein (KHSRP; FUBP2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify KH-type splicing regulatory protein (KHSRP; FUBP2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify KH-type splicing regulatory protein (KHSRP; FUBP2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of KH-type splicing regulatory protein (KHSRP, FUBP2) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC99676

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding HDA PubMed 
enables mRNA 3'-UTR AU-rich region binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein folding chaperone EXP
Inferred from Experiment
more info
 PubMed 
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA destabilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in 3'-UTR-mediated mRNA destabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in RNA splicing TAS
Traceable Author Statement
more info
 PubMed 
involved_in RNA splicing, via transesterification reactions TAS
Traceable Author Statement
more info
 PubMed 
involved_in cellular response to cytokine stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in miRNA metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of low-density lipoprotein particle clearance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of nitric oxide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of mRNA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mRNA stability IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of exosome (RNase complex) NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
far upstream element-binding protein 2
Names
FUSE-binding protein 2
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001366299.1 → NP_001353228.1  far upstream element-binding protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC011491, AC011539
    Consensus CDS
    CCDS92499.1
    UniProtKB/TrEMBL
    A0A384P5V3, M0R0C6
    Related
    ENSP00000471146.2, ENST00000600480.2
    Conserved Domains (5) summary
    pfam09005
    Location:671 → 685
    DUF1897; Domain of unknown function (DUF1897)
    cd22479
    Location:145 → 215
    KH-I_FUBP2_rpt1; first type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
    cd22482
    Location:233 → 305
    KH-I_FUBP2_rpt2; second type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
    cd22485
    Location:323 → 390
    KH-I_FUBP2_rpt3; third type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
    cd22488
    Location:426 → 494
    KH-I_FUBP2_rpt4; fourth type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins

  2. NM_001366300.1 → NP_001353229.1  far upstream element-binding protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC011491, AC011539
    UniProtKB/TrEMBL
    A0A384P5V3
    Conserved Domains (5) summary
    pfam09005
    Location:646 → 660
    DUF1897; Domain of unknown function (DUF1897)
    cd22479
    Location:145 → 215
    KH-I_FUBP2_rpt1; first type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
    cd22482
    Location:233 → 305
    KH-I_FUBP2_rpt2; second type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
    cd22485
    Location:323 → 390
    KH-I_FUBP2_rpt3; third type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
    cd22488
    Location:426 → 494
    KH-I_FUBP2_rpt4; fourth type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins

  3. NM_003685.3 → NP_003676.2  far upstream element-binding protein 2 isoform 1

    See identical proteins and their annotated locations for NP_003676.2

    Status: VALIDATED

    Source sequence(s)
    AA976482, AC011491, BC085004, BQ186683, CB216491, CF123311, DC388502, U94832
    Consensus CDS
    CCDS45936.1
    UniProtKB/Swiss-Prot
    O00301, Q59EZ9, Q5U4P6, Q92945, Q9UNT5, Q9UQH5
    UniProtKB/TrEMBL
    A0A384P5V3
    Related
    ENSP00000381216.2, ENST00000398148.7
    Conserved Domains (5) summary
    pfam09005
    Location:671 → 685
    DUF1897; Domain of unknown function (DUF1897)
    cd22479
    Location:145 → 215
    KH-I_FUBP2_rpt1; first type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
    cd22482
    Location:233 → 305
    KH-I_FUBP2_rpt2; second type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
    cd22485
    Location:323 → 390
    KH-I_FUBP2_rpt3; third type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
    cd22488
    Location:426 → 494
    KH-I_FUBP2_rpt4; fourth type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    6413102..6424811 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    6401987..6413694 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q92945.4 GenPept UniProtKB/Swiss-Prot:Q92945

Gene LinkOut

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