ALG6 dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: ALG6
Gene description: dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase
Primary source: SGD:S000005528
Locus tag: YOR002W
See related: AllianceGenome:SGD:S000005528
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity. Involved in aerobic respiration; oligosaccharide-lipid intermediate biosynthetic process; and protein glycosylation. Located in endoplasmic reticulum. Used to study congenital disorder of glycosylation type I. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ic. Orthologous to human ALG6 (ALG6 alpha-1,3-glucosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (329417..331051)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results define the architecture of endoplasmic reticulum-luminal glycosyltransferases of the C-superfamily and provide a structural basis for understanding their catalytic mechanisms
Title: Structure and mechanism of the ER-based glucosyltransferase ALG6.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables hexosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables hexosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in aerobic respiration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oligosaccharide-lipid intermediate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in oligosaccharide-lipid intermediate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein N-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info
involved_in protein glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase

NP_014644.1

EC 2.4.1.267

ER-luminal alpha 1,3 glucosyltransferase; involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; C998T transition in human ortholog ALG6 causes carbohydrate-deficient glycoprotein syndrome type-Ic; wild-type human ortholog ALG6 can partially complement yeast alg6 mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

329417..331051

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183421.1 → NP_014644.1 TPA: dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014644.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W268, E9P8Y7, Q12001

UniProtKB/TrEMBL

B5VRQ4

Conserved Domains (1) summary

pfam03155
Location:64 → 528

Alg6_Alg8; ALG6, ALG8 glycosyltransferase family