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NAT2 Nat2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853050, updated on 13-Apr-2024

Summary

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Gene symbol
NAT2
Gene description
Nat2p
Primary source
SGD:S000003379
Locus tag
YGR147C
See related
AllianceGenome:SGD:S000003379
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable acyltransferase activity. Involved in N-terminal peptidyl-methionine acetylation. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (786054..786920, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Ecl1p Neighboring gene uncharacterized protein Neighboring gene ribosomal 60S subunit protein L24B Neighboring gene glycerophosphocholine acyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A N(alpha)-acetyltransferase selectively transfers an acetyl group to NH2-terminal methionine residues: purification and partial characterization. Lee FJ, et al. Biochim Biophys Acta, 1997 Apr 4. PMID 9128142
  2. NAT2, an essential gene encoding methionine N alpha-acetyltransferase in the yeast Saccharomyces cerevisiae. Kulkarni MS, et al. J Biol Chem, 1994 May 6. PMID 8175741
  3. INA complex liaises the F(1)F(o)-ATP synthase membrane motor modules. Naumenko N, et al. Nat Commun, 2017 Nov 1. PMID 29093463, Free PMC Article
  4. Molecular Connectivity of Mitochondrial Gene Expression and OXPHOS Biogenesis. Singh AP, et al. Mol Cell, 2020 Sep 17. PMID 32877643
  5. Mapping pathways and phenotypes by systematic gene overexpression. Sopko R, et al. Mol Cell, 2006 Feb 3. PMID 16455487

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in N-terminal peptidyl-methionine acetylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Nat2p
NP_011663.3
  • hypothetical protein; has an apparent role in acetylation of N-terminal methionine residues

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    786054..786920 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181276.3 → NP_011663.3  TPA: Nat2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011663.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUS8, P37293
    UniProtKB/TrEMBL
    A0A6A5PZT7, G2WEM8, N1P9X1
    Conserved Domains (1) summary
    pfam06916
    Location:93 → 221
    DUF1279; Protein of unknown function (DUF1279)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P37293.2

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