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MET17 bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase MET17 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851010, updated on 11-Apr-2024

Summary

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Gene symbol
MET17
Gene description
bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase MET17
Primary source
SGD:S000004294
Locus tag
YLR303W
See related
AllianceGenome:SGD:S000004294
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MET15; MET25
Summary
Enables O-acetylhomoserine aminocarboxypropyltransferase activity and cysteine synthase activity. Involved in methionine metabolic process. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (732542..733876)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Hri1p Neighboring gene tRNA-Leu Neighboring gene uncharacterized protein Neighboring gene tRNA-Ile Neighboring gene aconitate hydratase ACO1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of Genes in Saccharomyces cerevisiae that Are Haploinsufficient for Overcoming Amino Acid Starvation. Bae NS, et al. G3 (Bethesda), 2017 Apr 3. PMID 28209762, Free PMC Article
  2. Genomic promoter replacement cassettes to alter gene expression in the yeast Saccharomyces cerevisiae. Kaufmann A, et al. Methods Mol Biol, 2011. PMID 21815098
  3. Transgenic tobacco plants overexpressing the Met25 gene of Saccharomyces cerevisiae exhibit enhanced levels of cysteine and glutathione and increased tolerance to oxidative stress. Matityahu I, et al. Amino Acids, 2006 Mar. PMID 16193226
  4. Heterologous protein production from the inducible MET25 promoter in Saccharomyces cerevisiae. Solow SP, et al. Biotechnol Prog, 2005 Mar-Apr. PMID 15801808
  5. Cloning of the O-acetylhomoserine sulfhydrylase gene from the ruminal bacterium Selenomonas ruminantium HD4. Qin X, et al. Curr Microbiol, 2004 Apr. PMID 15057458

See all (108) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Western analysis revealed reduced expression of Met17p in the glo1 deletion, but there was no indication of an altered conformation of Met17p or any direct interaction between the two proteins
    Title: The GLO1 Gene Is Required for Full Activity of O-Acetyl Homoserine Sulfhydrylase Encoded by MET17.
  2. The overexpression of Cdc34 accelerated the ubiquitination of the transcription factor Met4 and reduced expression of MET25 gene, which is a target of Met4.
    Title: Ubiquitin-conjugating enzyme Cdc34 mediates cadmium resistance in budding yeast through ubiquitination of the transcription factor Met4.
  3. Transgenic tobacco plants expressing the yeast MET25 gene under the control of a constitutive promoter and targeted the yeast protein to the cytosol or to the chloroplasts.
    Title: Transgenic tobacco plants overexpressing the Met25 gene of Saccharomyces cerevisiae exhibit enhanced levels of cysteine and glutathione and increased tolerance to oxidative stress.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables O-acetylhomoserine aminocarboxypropyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables O-acetylhomoserine aminocarboxypropyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables O-acetylhomoserine aminocarboxypropyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables O-acetylhomoserine aminocarboxypropyltransferase activity TAS
Traceable Author Statement
more info
 PubMed 
enables O-acetylhomoserine sulfhydrylase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity, transferring alkyl or aryl (other than methyl) groups IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' L-methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in L-homocysteine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cysteine biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in cysteine biosynthetic process from serine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in methionine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transsulfuration IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase MET17
NP_013406.1
  • O-acetyl homoserine-O-acetyl serine sulfhydrylase; involved in methionine and cysteine biosynthesis; long considered essential for inorganic sulfur assimilation, but inefficient homocysteine synthase Hsu1p enables met17 null cells to assimilate enough inorganic sulfur for survival and proliferation; growth failure of met17 null can be explained by toxic accumulation of H2S gas due to a metabolic bottleneck

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    732542..733876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182191.1 → NP_013406.1  TPA: bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase MET17 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013406.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYU6, P06106
    UniProtKB/TrEMBL
    A0A0P0BRV9, A0A0P0C0N3, A7A1I7, B3RHI1, B5VNK3, C8ZDR6, N1NZZ7
    Conserved Domains (1) summary
    TIGR01326
    Location:4 → 436
    OAH_OAS_sulfhy; OAH/OAS sulfhydrylase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06106.3

Gene LinkOut

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